Search Results - "Le May, Cédric"

Gestational cholestyramine treatment protects adult offspring of ApoE‐deficient mice against maternal‐hypercholesterolemia‐induced atherosclerosis by Habib, Marina, Croyal, Mikael, Kaeffer, Bertrand, Grit, Isabelle, Castellano, Blandine, Gourdel, Mathilde, Le May, Cédric, Thorin, Chantal, Nazih, Hassan, Ouguerram, Khadija

“…Aim Perinatal hypercholesterolemia exacerbates the development of atherosclerotic plaques in adult offspring. Here, we aimed to study the effect of maternal…”
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Primary hypocholesterolemia is associated with an increased risk of hepatic complications in the general population by Wargny, Matthieu, Goronflot, Thomas, Rimbert, Antoine, Boursier, Jérôme, Kab, Sofiane, Henny, Joseph, Lainé, Antoine, Leux, Christophe, Smati, Sarra, Hadjadj, Samy, Le May, Cédric, Goldberg, Marcel, Zins, Marie, Cariou, Bertrand

“…Beyond cardiovascular disease protection, the health consequences of very low concentrations of low-density lipoprotein-cholesterol (LDL-C) remain a matter of…”
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Transintestinal Cholesterol Excretion Is an Active Metabolic Process Modulated by PCSK9 and Statin Involving ABCB1 by Le May, Cédric, Berger, Jean Mathieu, Lespine, Anne, Pillot, Bruno, Prieur, Xavier, Letessier, Eric, Hussain, M Mahmood, Collet, Xavier, Cariou, Bertrand, Costet, Philippe

“…OBJECTIVE—Transintestinal cholesterol excretion (TICE) is an alternate pathway to hepatobiliary secretion. Our study aimed at identifying molecular mechanisms…”
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Empagliflozin mitigates metabolic dysfunction‐associated steatotic liver disease by reducing de novo lipogenesis in a mouse model of lipoatrophic diabetes by Smati, Sarra, Sotin, Thibaud, Deniel, Perrine, Ducheix, Simon, Joubert, Michael, Arnaud, Lucie, Hadjadj, Samy, Cariou, Bertrand, Le May, Cédric, Prieur, Xavier

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The Complex ABCG5/ABCG8 Regulates Vitamin D Absorption Rate and Contributes to its Efflux from the Intestine by Antoine, Tiffany, Le May, Cédric, Margier, Marielle, Halimi, Charlotte, Nowicki, Marion, Defoort, Catherine, Svilar, Ljubica, Reboul, Emmanuelle

“…Scope Most people are vitamin D insufficient around the world. Vitamin D intestinal absorption should thus be optimized. The role of the ATP‐binging cassette…”
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PCSK9 Concentrations in Cerebrospinal Fluid Are Not Specifically Increased in Alzheimer's Disease by Courtemanche, Hélène, Bigot, Edith, Pichelin, Matthieu, Guyomarch, Béatrice, Boutoleau-Bretonnière, Claire, Le May, Cédric, Derkinderen, Pascal, Cariou, Bertrand

“…The role of PCSK9 in Alzheimer's disease (AD) is controversial. We compared cerebrospinal fluid (CSF) PCSK9 concentrations in 36 AD and 31 non-AD patients. CSF…”
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Control of gene expression by fatty acids by Pégorier, Jean-Paul, Le May, Cédric, Girard, Jean

“…The last decade provided evidence that major (glucose, fatty acids, amino acids) or minor (iron, vitamin, etc.) dietary constituents regulated gene expression…”
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Generation of a GPR146 knockout human induced pluripotent stem cell line (ITXi001-A-1) by Bray, Lise, Caillaud, Amandine, Girardeau, Aurore, Patitucci, Murielle, Le May, Cédric, Cariou, Bertrand, Rimbert, Antoine

“…Dyslipidemia is a key modifiable causal risk factor involved in the development of atherosclerotic cardiovascular disease. Recently, the G protein-coupled…”
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Plasma apolipoprotein concentrations and incident diabetes in subjects with prediabetes by Croyal, Mikaël, Wargny, Matthieu, Chemello, Kevin, Chevalier, Chloé, Blanchard, Valentin, Bigot-Corbel, Edith, Lambert, Gilles, Le May, Cédric, Hadjadj, Samy, Cariou, Bertrand

“…The identification of circulating biomarkers associated with the risk of type 2 diabetes (T2D) is useful for improving the current prevention strategies in the…”
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Generation of an induced pluripotent stem cell line (ITXi012-A) from a patient with genetically determined high-lipoprotein(a) plasma levels by Caillaud, Amandine, Bray, Lise, Girardeau, Aurore, Begué-Racapé, Zoé, Vince, Lucie, Patitucci, Murielle, Le May, Cédric, Lambert, Gilles, Cariou, Bertrand, Rimbert, Antoine

“…Elevated circulating lipoprotein(a) (Lp(a)) is a genetically determined risk factor for coronary artery disease and aortic valve stenosis (Tsimikas, 2017)…”
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Urine-sample-derived human induced pluripotent stem cells as a model to study PCSK9-mediated autosomal dominant hypercholesterolemia by Si-Tayeb, Karim, Idriss, Salam, Champon, Benoite, Caillaud, Amandine, Pichelin, Matthieu, Arnaud, Lucie, Lemarchand, Patricia, Le May, Cédric, Zibara, Kazem, Cariou, Bertrand

“…Proprotein convertase subtilisin kexin type 9 (PCSK9) is a critical modulator of cholesterol homeostasis. Whereas PCSK9 gain-of-function (GOF) mutations are…”
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Effect of Parathyroidectomy on Metabolic Homeostasis in Primary Hyperparathyroidism by Frey, Samuel, Bourgade, Raphaël, Le May, Cédric, Croyal, Mikaël, Bigot-Corbel, Edith, Renaud-Moreau, Nelly, Wargny, Matthieu, Caillard, Cécile, Mirallié, Eric, Cariou, Bertrand, Blanchard, Claire

“…Background: The benefits of parathyroidectomy on cardiovascular risk in primary hyperparathyroidism (PHPT) are controversial. This monocentric, observational,…”
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E2F1 inhibits circulating cholesterol clearance by regulating Pcsk9 expression in the liver by Lai, Qiuwen, Giralt, Albert, Le May, Cédric, Zhang, Lianjun, Cariou, Bertrand, Denechaud, Pierre-Damien, Fajas, Lluis

“…Cholesterol accumulation in the liver is an early event in nonalcoholic fatty liver disease (NAFLD). Here, we demonstrate that E2F1 plays a crucial role in…”
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PAX4 gene variations predispose to ketosis-prone diabetes by Mauvais-Jarvis, Franck, Smith, Stuart B., May, Cédric Le, Leal, Suzanne M., Gautier, Jean-François, Molokhia, Mariam, Riveline, Jean-Pierre, Rajan, Arun S., Kevorkian, Jean-Philippe, Zhang, Sumei, Vexiau, Patrick, German, Michael S., Vaisse, Christian

“…Ketosis-prone diabetes (KPD) is a rare form of type 2 diabetes, mostly observed in subjects of west African origin (west Africans and African-Americans),…”
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Taste-Driven Responsiveness to Fat and Sweet Stimuli in Mouse Models of Bariatric Surgery by Dastugue, Aurélie, Le May, Cédric, Ledoux, Séverine, Le Bourgot, Cindy, Delaby, Pascaline, Bernard, Arnaud, Besnard, Philippe

“…A preferential consumption of healthier foods, low in fat and sugar, is often reported after bariatric surgery, suggesting a switch of taste-guided food…”
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Association between plasma PCSK9 and gamma-glutamyl transferase levels in diabetic patients by Cariou, Bertrand, Le Bras, Maëlle, Langhi, Cédric, Le May, Cédric, Guyomarc’h-Delasalle, Béatrice, Krempf, Michel, Costet, Philippe

“…Abstract Background Proprotein convertase subtilisin kexin type 9 (PCSK9) is a secreted proprotein convertase acting as a natural inhibitor of the low-density…”
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Clinical aspects of PCSK9 by Cariou, Bertrand, Le May, Cédric, Costet, Philippe

“…Abstract Proprotein convertase subtilisin kexin type 9 (PCSK9) is a circulating protein that impairs LDL clearance by promoting the LDL receptor (LDLR)…”
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Beyond LDL: What Role for PCSK9 in Triglyceride-Rich Lipoprotein Metabolism? by Dijk, Wieneke, Le May, Cédric, Cariou, Bertrand

“…Elevated plasma triglyceride (TG) levels are an independent risk factor for cardiovascular disease (CVD). Proprotein convertase subtilisin-kexin 9 (PCSK9) – a…”
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Routine use of statins and increased COVID-19 related mortality in inpatients with type 2 diabetes: Results from the CORONADO study by Cariou, Bertrand, Goronflot, Thomas, Rimbert, Antoine, Boullu, Sandrine, Le May, Cédric, Moulin, Philippe, Pichelin, Matthieu, Potier, Louis, Smati, Sarra, Sultan, Ariane, Tramunt, Blandine, Wargny, Matthieu, Gourdy, Pierre, Hadjadj, Samy

“…Patients with type 2 diabetes mellitus (T2DM) represent a high-risk population for both cardiovascular diseases and severe coronavirus disease 2019 (COVID-19)…”
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The Sodium-Glucose Cotransporter 2 Inhibitor Dapagliflozin Prevents Cardiomyopathy in a Diabetic Lipodystrophic Mouse Model by Joubert, Michael, Jagu, Benoît, Montaigne, David, Marechal, Xavier, Tesse, Angela, Ayer, Audrey, Dollet, Lucile, Le May, Cédric, Toumaniantz, Gilles, Manrique, Alain, Charpentier, Flavien, Staels, Bart, Magré, Jocelyne, Cariou, Bertrand, Prieur, Xavier

“…Type 2 diabetes mellitus (T2DM) is a well-recognized independent risk factor for heart failure. T2DM is associated with altered cardiac energy metabolism,…”
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