Search Results - "Le, Yun Z"

Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice by Venkatesh, Aditya, Ma, Shan, Le, Yun Z, Hall, Michael N, Rüegg, Markus A, Punzo, Claudio

“…Retinitis pigmentosa (RP) is an inherited photoreceptor degenerative disorder that results in blindness. The disease is often caused by mutations in genes that…”
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The Circadian Clock in the Retinal Pigment Epithelium Controls the Diurnal Rhythm of Phagocytic Activity by DeVera, Christopher, Dixon, Jendayi, Chrenek, Micah A, Baba, Kenkichi, Le, Yun Z, Iuvone, P Michael, Tosini, Gianluca

“…The diurnal peak of phagocytosis by the retinal pigment epithelium (RPE) of photoreceptor outer segments (POS) is under circadian control and believed that…”
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Conditional knockdown of DNA methyltransferase 1 reveals a key role of retinal pigment epithelium integrity in photoreceptor outer segment morphogenesis by Nasonkin, Igor O, Merbs, Shannath L, Lazo, Kevin, Oliver, Verity F, Brooks, Matthew, Patel, Krushangi, Enke, Raymond A, Nellissery, Jacob, Jamrich, Milan, Le, Yun Z, Bharti, Kapil, Fariss, Robert N, Rachel, Rivka A, Zack, Donald J, Rodriguez-Boulan, Enrique J, Swaroop, Anand

“…Dysfunction or death of photoreceptors is the primary cause of vision loss in retinal and macular degenerative diseases. As photoreceptors have an intimate…”
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Loss of Extracellular Signal-Regulated Kinase 1/2 in the Retinal Pigment Epithelium Leads to RPE65 Decrease and Retinal Degeneration by Pyakurel, Aswin, Balmer, Delphine, Saba-El-Leil, Marc K., Kizilyaprak, Caroline, Daraspe, Jean, Humbel, Bruno M., Voisin, Laure, Le, Yun Z., von Lintig, Johannes, Meloche, Sylvain, Roduit, Raphaël

“…Recent work suggested that the activity of extracellular signal-regulated kinase 1/2 (ERK1/2) is increased in the retinal pigment epithelium (RPE) of…”
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Loss of Neuroprotective Survival Signal in Mice Lacking Insulin Receptor Gene in Rod Photoreceptor Cells by Rajala, Ammaji, Tanito, Masaki, Le, Yun Z., Kahn, C. Ronald, Rajala, Raju V.S.

“…Insulin receptor (IR) signaling provides a trophic signal for transformed retinal neurons in culture, but the role of IR activity in vivo is unknown. We…”
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Diabetic retinopathy, an overview by Hartnett, M. Elizabeth, Baehr, Wolfgang, Le, Yun Z.

“…This overview introduces contributions to a special issue on causes of vision loss from diabetes mellitus, focusing on the retina and also the cornea. Diabetic…”
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Corneal Epithelial Cells Exhibit Myeloid Characteristics and Present Antigen via MHC Class II by Royer, Derek J, Elliott, Michael H, Le, Yun Z, Carr, Daniel J J

“…To explore the impact of ocular surface insults on the immunomodulatory capacity and phenotype of corneal epithelial cells (CECs) with a focus on…”
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Effects of Cone Connexin-36 Disruption on Light Adaptation and Circadian Regulation of the Photopic ERG by Zhang, Shuo, Lyuboslavsky, Polina, Dixon, Jendayi Azeezah, Chrenek, Micah A, Sellers, Jana T, Hamm, Jessica M, Ribelayga, Christophe P, Zhang, Zhijing, Le, Yun Z, Iuvone, P Michael

“…The present study tested the hypothesis that connexin-36 (Cx36) and gap junctions between photoreceptor cells contribute to the circadian rhythm of the…”
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Loss of mTOR signaling affects cone function, cone structure and expression of cone specific proteins without affecting cone survival by Ma, Shan, Venkatesh, Aditya, Langellotto, Fernanda, Le, Yun Z., Hall, Michael N., Rüegg, Markus A., Punzo, Claudio

“…Cones are the primary photoreceptor (PR) cells responsible for vision in humans. They are metabolically highly active requiring phosphoinositide 3-kinase…”
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Conditional Induction of Oxidative Stress in RPE: A Mouse Model of Progressive Retinal Degeneration by Biswal, Manas R, Ildefonso, Cristhian J, Mao, Haoyu, Seo, Soo Jung, Wang, Zhaoyang, Li, Hong, Le, Yun Z, Lewin, Alfred S

“…An appropriate animal model is essential to screening drugs or designing a treatment strategy for geographic atrophy. Since oxidative stress contributes to the…”
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Trafficking of Membrane Proteins to Cone But Not Rod Outer Segments Is Dependent on Heterotrimeric Kinesin-II by Avasthi, Prachee, Watt, Carl B, Williams, David S, Le, Yun Z, Li, Sha, Chen, Ching-Kang, Marc, Robert E, Frederick, Jeanne M, Baehr, Wolfgang

“…Heterotrimeric kinesin-II is a molecular motor localized to the inner segment, connecting cilium and axoneme of mammalian photoreceptors. Our purpose was to…”
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Phosphoinositide 3-kinase signaling in retinal rod photoreceptors by Ivanovic, Ivana, Allen, Dustin T, Dighe, Radhika, Le, Yun Z, Anderson, Robert E, Rajala, Raju V S

“…Phosphoinositide 3-kinase (PI3K) consists of a p110 catalytic protein and a p85α regulatory protein, required for the stabilization and localization of…”
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Phosphoinositide 3-Kinase Signaling in Retinal Rod Photoreceptors by Ivanovic, Ivana, Allen, Dustin T., Dighe, Radhika, Le, Yun Z., Anderson, Robert E., Rajala, Raju V. S.

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Deletion of the p85α Regulatory Subunit of Phosphoinositide 3-Kinase in Cone Photoreceptor Cells Results in Cone Photoreceptor Degeneration by Ivanovic, Ivana, Anderson, Robert E., Le, Yun Z., Fliesler, Steven J., Sherry, David M., Rajala, Raju V. S.

“…The present study suggests that PI3K signaling pathway is essential for cone photoreceptor survival in mouse retina…”
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Loss of Neuroprotective Survival Signal in Mice Lacking Insulin Receptor Gene in Rod Photoreceptor CellsS by Rajala, Ammaji, Tanito, Masaki, Le, Yun Z., Kahn, C. Ronald, Rajala, Raju V. S.

“…Insulin receptor (IR) signaling provides a trophic signal for transformed retinal neurons in culture, but the role of IR activity in vivo is unknown. We…”
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Deletion of the p85alpha regulatory subunit of phosphoinositide 3-kinase in cone photoreceptor cells results in cone photoreceptor degeneration by Ivanovic, Ivana, Anderson, Robert E, Le, Yun Z, Fliesler, Steven J, Sherry, David M, Rajala, Raju V S

“…Downregulation of the retinal insulin/mTOR pathway in mouse models of retinitis pigmentosa is linked to cone cell death, which can be delayed by systemic…”
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