Search Results - "Le, Tung B"

High-Resolution Mapping of the Spatial Organization of a Bacterial Chromosome by Le, Tung B. K., Imakaev, Maxim V., Mirny, Leonid A., Laub, Michael T.

“…Chromosomes must be highly compacted and organized within cells, but how this is achieved in vivo remains poorly understood. We report the use of chromosome…”
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Control of a gene transfer agent cluster in Caulobacter crescentus by transcriptional activation and anti-termination by Tran, Ngat T., Le, Tung B. K.

“…Gene Transfer Agents (GTAs) are phage-like particles that cannot self-multiply and be infectious. Caulobacter crescentus , a bacterium best known as a model…”
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Cell cycle-dependent organization of a bacterial centromere through multi-layered regulation of the ParABS system by Kaljević, Jovana, Tesseur, Coralie, Le, Tung B K, Laloux, Géraldine

“…The accurate distribution of genetic material is crucial for all organisms. In most bacteria, chromosome segregation is achieved by the ParABS system, in which…”
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Bacterial Chromosome Organization and Segregation by Badrinarayanan, Anjana, Le, Tung B.K, Laub, Michael T

“…If fully stretched out, a typical bacterial chromosome would be nearly 1 mm long, approximately 1,000 times the length of a cell. Not only must cells massively…”
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Bidirectional pilus processing in the Tad pilus system motor CpaF by Hohl, Michael, Banks, Emma J., Manley, Max P., Le, Tung B. K., Low, Harry H.

“…The bacterial tight adherence pilus system (TadPS) assembles surface pili essential for adhesion and colonisation in many human pathogens. Pilus dynamics are…”
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Widespread prevalence of a methylation-dependent switch to activate an essential DNA damage response in bacteria by Kamat, Aditya, Tran, Ngat T, Sharda, Mohak, Sontakke, Neha, Le, Tung B K, Badrinarayanan, Anjana

“…DNA methylation plays central roles in diverse cellular processes, ranging from error-correction during replication to regulation of bacterial defense…”
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Bacillus subtilis SMC complexes juxtapose chromosome arms as they travel from origin to terminus by Wang, Xindan, Brandão, Hugo B., Le, Tung B. K., Laub, Michael T., Rudner, David Z.

“…Structural maintenance of chromosomes (SMC) complexes play critical roles in chromosome dynamics in virtually all organisms, but how they function remains…”
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Spatial rearrangement of the Streptomyces venezuelae linear chromosome during sporogenic development by Szafran, Marcin J., Małecki, Tomasz, Strzałka, Agnieszka, Pawlikiewicz, Katarzyna, Duława, Julia, Zarek, Anna, Kois-Ostrowska, Agnieszka, Findlay, Kim C., Le, Tung B. K., Jakimowicz, Dagmara

“…Bacteria of the genus Streptomyces have a linear chromosome, with a core region and two ‘arms’. During their complex life cycle, these bacteria develop…”
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Prophage-like gene transfer agents promote Caulobacter crescentus survival and DNA repair during stationary phase by Gozzi, Kevin, Tran, Ngat T, Modell, Joshua W, Le, Tung B K, Laub, Michael T

“…Gene transfer agents (GTAs) are prophage-like entities found in many bacterial genomes that cannot propagate themselves and instead package approximately 5 to…”
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Condensin promotes the juxtaposition of DNA flanking its loading site in Bacillus subtilis by Wang, Xindan, Le, Tung B K, Lajoie, Bryan R, Dekker, Job, Laub, Michael T, Rudner, David Z

“…SMC condensin complexes play a central role in compacting and resolving replicated chromosomes in virtually all organisms, yet how they accomplish this remains…”
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Permissive zones for the centromere-binding protein ParB on the Caulobacter crescentus chromosome by Tran, Ngat T, Stevenson, Clare E, Som, Nicolle F, Thanapipatsiri, Anyarat, Jalal, Adam S B, Le, Tung B K

“…Abstract Proper chromosome segregation is essential in all living organisms. In Caulobacter crescentus, the ParA-ParB-parS system is required for proper…”
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Author Correction: Spatial rearrangement of the Streptomyces venezuelae linear chromosome during sporogenic development by Szafran, Marcin J., Małecki, Tomasz, Strzałka, Agnieszka, Pawlikiewicz, Katarzyna, Duława, Julia, Zarek, Anna, Kois-Ostrowska, Agnieszka, Findlay, Kim C., Le, Tung B. K., Jakimowicz, Dagmara

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Bacterial chromosome segregation by the ParABS system by Jalal, Adam S B, Le, Tung B K

“…Proper chromosome segregation during cell division is essential in all domains of life. In the majority of bacterial species, faithful chromosome segregation…”
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Global analysis of double-strand break processing reveals in vivo properties of the helicase-nuclease complex AddAB by Badrinarayanan, Anjana, Le, Tung B K, Spille, Jan-Hendrik, Cisse, Ibrahim I, Laub, Michael T

“…In bacteria, double-strand break (DSB) repair via homologous recombination is thought to be initiated through the bi-directional degradation and resection of…”
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Mechanistic insight into the repair of C8-linked pyrrolobenzodiazepine monomer-mediated DNA damage by Joseph, Asha Mary, Nahar, Kazi, Daw, Saheli, Hasan, Md. Mahbub, Lo, Rebecca, Le, Tung B. K, Rahman, Khondaker Miraz, Badrinarayanan, Anjana

“…Pyrrolobenzodiazepines (PBDs) are naturally occurring DNA binding compounds that possess anti-tumor and anti-bacterial activity. Chemical modifications of PBDs…”
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Rapid pairing and resegregation of distant homologous loci enables double-strand break repair in bacteria by Badrinarayanan, Anjana, Le, Tung B K, Laub, Michael T

“…Double-strand breaks (DSBs) can lead to the loss of genetic information and cell death. Although DSB repair via homologous recombination has been well…”
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The crystal structure of the TetR family transcriptional repressor SimR bound to DNA and the role of a flexible N-terminal extension in minor groove binding by Le, Tung B. K., Schumacher, Maria A., Lawson, David M., Brennan, Richard G., Buttner, Mark J.

“…SimR, a TetR-family transcriptional regulator (TFR), controls the export of simocyclinone, a potent DNA gyrase inhibitor made by Streptomyces antibioticus…”
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Transcription rate and transcript length drive formation of chromosomal interaction domain boundaries by Le, Tung BK, Laub, Michael T

“…Chromosomes in all organisms are highly organized and divided into multiple chromosomal interaction domains, or topological domains. Regions of active, high…”
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A Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8, Bound to DNA Gyrase by Edwards, Marcus J., Flatman, Ruth H., Mitchenall, Lesley A., Stevenson, Clare E. M., Le, Tung B. K., Clarke, Thomas A., McKay, Adam R., Fiedler, Hans-Peter, Buttner, Mark J., Lawson, David M., Maxwell, Anthony

“…Simocyclinones are bifunctional antibiotics that inhibit bacterial DNA gyrase by preventing DNA binding to the enzyme. We report the crystal structure of the…”
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ParB spreading on DNA requires cytidine triphosphate in vitro by Jalal, Adam Sb, Tran, Ngat T, Le, Tung Bk

“…In all living organisms, it is essential to transmit genetic information faithfully to the next generation. The SMC-ParAB- system is widely employed for…”
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