Search Results - "Le, Timothy"

Pilot study of a machine‐learning tool to assist in the diagnosis of hand arthritis by Reed, Mark, Le Souëf, Timothy, Rampono, Elliot

“…Background Arthritis is a common condition, which frequently involves the hands. Patients with inflammatory arthritis have been shown to experience significant…”
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Diverse evolutionary patterns of pneumococcal antigens identified by pangenome-wide immunological screening by Croucher, Nicholas J., Campo, Joseph J., Le, Timothy Q., Liang, Xiaowu, Bentley, Stephen D., Hanage, William P., Lipsitch, Marc

“…Characterizing the immune response to pneumococcal proteins is critical in understanding this bacterium’s epidemiology and vaccinology. Probing a…”
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Genomic and panproteomic analysis of the development of infant immune responses to antigenically-diverse pneumococci by Croucher, Nicholas J., Campo, Joseph J., Le, Timothy Q., Pablo, Jozelyn V., Hung, Christopher, Teng, Andy A., Turner, Claudia, Nosten, François, Bentley, Stephen D., Liang, Xiaowu, Turner, Paul, Goldblatt, David

“…Streptococcus pneumoniae (pneumococcus) is a nasopharyngeal commensal and respiratory pathogen. This study characterises the immunoglobulin G (IgG) repertoire…”
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Diesel exhaust particle induction of IL-17A contributes to severe asthma by Brandt, Eric B., MD, PhD, Kovacic, Melinda Butsch, PhD, Lee, Gerald B., MD, Gibson, Aaron M., BS, Acciani, Thomas H., BS, Le Cras, Timothy D., PhD, Ryan, Patrick H., PhD, Budelsky, Alison L., PhD, Khurana Hershey, Gurjit K., MD, PhD

“…Background IL-17A has been implicated in severe forms of asthma. However, the factors that promote IL-17A production during the pathogenesis of severe asthma…”
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Naturally acquired immunity against immature Plasmodium falciparum gametocytes by Dantzler, Kathleen W, Ma, Siyuan, Ngotho, Priscilla, Stone, Will J R, Tao, Dingyin, Rijpma, Sanna, De Niz, Mariana, Nilsson Bark, Sandra K, Jore, Matthijs M, Raaijmakers, Tonke K, Early, Angela M, Ubaida-Mohien, Ceereena, Lemgruber, Leandro, Campo, Joseph J, Teng, Andy A, Le, Timothy Q, Walker, Cassidy L, Hermand, Patricia, Deterre, Philippe, Davies, D Huw, Felgner, Phil, Morlais, Isabelle, Wirth, Dyann F, Neafsey, Daniel E, Dinglasan, Rhoel R, Laufer, Miriam, Huttenhower, Curtis, Seydel, Karl, Taylor, Terrie, Bousema, Teun, Marti, Matthias

“…The recent decline in global malaria burden has stimulated efforts toward elimination. Understanding the biology of malaria transmission stages may provide…”
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A picture on the wall: innovative mapping reveals cold-water coral refuge in submarine canyon by Huvenne, Veerle A I, Tyler, Paul A, Masson, Doug G, Fisher, Elizabeth H, Hauton, Chris, Hühnerbach, Veit, Le Bas, Timothy P, Wolff, George A

“…Cold-water corals are azooxanthellate species found throughout the ocean at water depths down to 5000 m. They occur in patches, reefs or large mound structures…”
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Constitutively active PIK3CA mutations are expressed by lymphatic and vascular endothelial cells in capillary lymphatic venous malformation by Le Cras, Timothy D., Goines, Jillian, Lakes, Nora, Pastura, Patricia, Hammill, Adrienne M., Adams, Denise M., Boscolo, Elisa

“…Capillary lymphatic venous malformations (CLVM) are complex vascular anomalies characterized by aberrant and enlarged lymphatic and blood vessels. CLVM appear…”
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Circulating level of Angiopoietin-2 is associated with acute kidney injury in coronavirus disease 2019 (COVID-19) by Henry, Brandon Michael, de Oliveira, Maria Helena Santos, Cheruiyot, Isaac, Benoit, Justin L., Cooper, David S., Lippi, Giuseppe, Le Cras, Timothy D., Benoit, Stefanie W.

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Proteome-wide analysis of a malaria vaccine study reveals personalized humoral immune profiles in Tanzanian adults by Camponovo, Flavia, Campo, Joseph J, Le, Timothy Q, Oberai, Amit, Hung, Christopher, Pablo, Jozelyn V, Teng, Andy A, Liang, Xiaowu, Sim, B Kim Lee, Jongo, Said, Abdulla, Salim, Tanner, Marcel, Hoffman, Stephen L, Daubenberger, Claudia, Penny, Melissa A

“…Tanzanian adult male volunteers were immunized by direct venous inoculation with radiation-attenuated, aseptic, purified, cryopreserved (Pf) sporozoites (PfSPZ…”
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Panproteome-wide analysis of antibody responses to whole cell pneumococcal vaccination by Campo, Joseph J, Le, Timothy Q, Pablo, Jozelyn V, Hung, Christopher, Teng, Andy A, Tettelin, Hervé, Tate, Andrea, Hanage, William P, Alderson, Mark R, Liang, Xiaowu, Malley, Richard, Lipsitch, Marc, Croucher, Nicholas J

“…Pneumococcal whole cell vaccines (WCVs) could cost-effectively protect against a greater strain diversity than current capsule-based vaccines. Immunoglobulin G…”
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Differential effects of rapamycin and dexamethasone in mouse models of established allergic asthma by Mushaben, Elizabeth M, Brandt, Eric B, Hershey, Gurjit K Khurana, Le Cras, Timothy D

“…The mammalian target of rapamycin (mTOR) plays an important role in cell growth/differentiation, integrating environmental cues, and regulating immune…”
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Minimal handgrip force is needed for transcutaneous electrical stimulation to improve hand functions of patients with severe spinal cord injury by Huang, Ruyi, Nikooyan, Ali A., Moore, Lisa D., Zdunowski, Sharon, Morikawa, Erika, Sierro, Tiffany, Sayenko, Dimitry, Gad, Parag, Homsey, Tali, Le, Timothy, Madhavan, Meghna A., Abdelshahid, Marina, Abdelshahid, Martina, Zhou, Yan, Nuwer, Mark R., Sarrafzadeh, Majid, Edgerton, V. Reggie, Leiter, James C., Lu, Daniel C.

“…Spinal cord stimulation enhanced restoration of motor function following spinal cord injury (SCI) in unblinded studies. To determine whether training combined…”
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Management of aortic occlusion in a morbidly obese smoker: A case report by Le, Timothy N, Roberts, David A, Kimyaghalam, Ali, Singh, Kuldeep

“…Total occlusion of the abdominal aorta is a rare and life-threatening event. Risk factors most commonly include coagulopathy, vasculitis, trauma, abdominal…”
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Placenta growth factor augments airway hyperresponsiveness via leukotrienes and IL-13 by Eiymo Mwa Mpollo, Marthe-Sandrine, Brandt, Eric B, Shanmukhappa, Shiva Kumar, Arumugam, Paritha I, Tiwari, Swati, Loberg, Anastacia, Pillis, Devin, Rizvi, Tilat, Lindsey, Mark, Jonck, Bart, Carmeliet, Peter, Kalra, Vijay K, Le Cras, Timothy D, Ratner, Nancy, Wills-Karp, Marsha, Hershey, Gurjit K Khurana, Malik, Punam

“…Airway hyperresponsiveness (AHR) affects 55%-77% of children with sickle cell disease (SCD) and occurs even in the absence of asthma. While asthma increases…”
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Independent and combined effects of airway remodelling and allergy on airway responsiveness by Wang, Kimberley C W, Le Cras, Timothy D, Larcombe, Alexander N, Zosky, Graeme R, Elliot, John G, James, Alan L, Noble, Peter B

“…Airway remodelling and allergic inflammation are key features of airway hyperresponsiveness (AHR) in asthma; however, their interrelationships are unclear. The…”
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Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma by Le Cras, Timothy D, Acciani, Thomas H, Mushaben, Elizabeth M, Kramer, Elizabeth L, Pastura, Patricia A, Hardie, William D, Korfhagen, Thomas R, Sivaprasad, Umasundari, Ericksen, Mark, Gibson, Aaron M, Holtzman, Michael J, Whitsett, Jeffrey A, Hershey, Gurjit K Khurana

“…Increases in the epidermal growth factor receptor (EGFR) have been associated with the severity of airway thickening in chronic asthmatic subjects, and EGFR…”
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Rapamycin attenuates airway hyperreactivity, goblet cells, and IgE in experimental allergic asthma by Mushaben, Elizabeth M, Kramer, Elizabeth L, Brandt, Eric B, Khurana Hershey, Gurjit K, Le Cras, Timothy D

“…The mammalian target of rapamycin (mTOR) signaling pathway integrates environmental cues, promotes cell growth/differentiation, and regulates immune responses…”
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Alarming increase in electronic nicotine delivery systems-related burn injuries: A serious unregulated public health issue by Toy, Jake, BA, Dong, Fanglong, PhD, Lee, Carol, MD, Zappa, Dane, BS, Le, Timothy, BS, Archambeau, Benjamin, DO, Culhane, John T., MD, Neeki, Michael M., DO, MS

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Factors Predictive of Mortality among Geriatric Patients Sustaining Low-Energy Blunt Trauma by Patel, Nikhil, Le, Timothy N, Demissie, Seleshi, Pandya, Shreya, Kania, Thomas, Copty, Michael, Alothman, Sara, Rost, Amy, Governo, Chris, DiRoma, Frank, Glinik, Galina, Atanassov, Krassimir, Khodorkovsky, Boris, Szerszen, Anita, Gave, Asaf, Younan, Duraid

“…Background: In geriatric trauma patients, higher mortality rate is observed compared to younger patients. A significant portion of trauma sustained by this age…”
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Chronic allergic inflammation causes vascular remodeling and pulmonary hypertension in BMPR2 hypomorph and wild-type mice by Mushaben, Elizabeth M, Hershey, Gurjit Khurana, Pauciulo, Michael W, Nichols, William C, Le Cras, Timothy D

“…Loss-of-function mutations in the bone morphogenetic protein receptor type 2 (BMPR2) gene have been identified in patients with heritable pulmonary arterial…”
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