Search Results - "Le, Steven"
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Second-Line Tisagenlecleucel or Standard Care in Aggressive B-Cell Lymphoma
Published in The New England journal of medicine (17-02-2022)“…A randomized trial comparing the CD19-specific CAR T-cell therapy tisagenlecleucel with salvage chemotherapy followed by high-dose therapy and autologous…”
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Acalabrutinib in relapsed or refractory mantle cell lymphoma (ACE-LY-004): a single-arm, multicentre, phase 2 trial
Published in The Lancet (British edition) (17-02-2018)“…Bruton tyrosine kinase is a clinically validated target in mantle cell lymphoma. Acalabrutinib (ACP-196) is a highly selective, potent Bruton tyrosine kinase…”
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Competitive Salt Precipitation/Dissolution During Free‐Water Reduction in Water‐in‐Salt Electrolyte
Published in Angewandte Chemie International Edition (07-09-2020)“…Water‐in‐salt electrolytes based on highly concentrated bis(trifluoromethyl)sulfonimide (TFSI) promise aqueous electrolytes with stabilities nearing 3 V…”
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PRC2 activates interferon-stimulated genes indirectly by repressing miRNAs in glioblastoma
Published in PloS one (12-09-2019)“…Polycomb repressive complex 2 (PRC2) is a chromatin binding complex that represses gene expression by methylating histone H3 at K27 to establish repressed…”
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The phase separation underlying the pyrenoid-based microalgal Rubisco supercharger
Published in Nature communications (29-11-2018)“…The slow and promiscuous properties of the CO 2 -fixing enzyme Rubisco constrain photosynthetic efficiency and have prompted the evolution of powerful CO 2…”
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Rituximab and dose-dense chemotherapy for adults with Burkitt's lymphoma: a randomised, controlled, open-label, phase 3 trial
Published in The Lancet (British edition) (11-06-2016)“…Summary Background Short intensive chemotherapy is the standard of care for adult patients with Burkitt's leukaemia or lymphoma. Findings from single-arm…”
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MicroRNAs reinforce repression of PRC2 transcriptional targets independently and through a feed-forward regulatory network
Published in Genome research (01-02-2019)“…Gene expression can be regulated at multiple levels, but it is not known if and how there is broad coordination between regulation at the transcriptional and…”
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Improving K-Nearest Neighbor Approaches for Density-Based Pixel Clustering in Hyperspectral Remote Sensing Images
Published in Remote sensing (Basel, Switzerland) (01-11-2020)“…We investigated nearest-neighbor density-based clustering for hyperspectral image analysis. Four existing techniques were considered that rely on a K-nearest…”
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The harmonized INFOGEST in vitro digestion method: From knowledge to action
Published in Food research international (01-10-2016)“…Within the active field of in vitro digestion in food research, the COST Action INFOGEST aimed to harmonize in vitro protocols simulating human digestion on…”
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Topology optimization of heat exchangers: A review
Published in Energy (Oxford) (01-08-2022)“…The critical importance of heat exchangers (HXs) on energy systems has been widely recognized, which can largely determine the overall efficiency. With the…”
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Addressing human-tiger conflict using socio-ecological information on tolerance and risk
Published in Nature communications (27-08-2018)“…Tigers are critically endangered due to deforestation and persecution. Yet in places, Sumatran tigers ( Panthera tigris sumatrae ) continue to coexist with…”
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Quality of life of survivors 1 year after the diagnosis of diffuse large B-cell lymphoma: a LYSA study
Published in Annals of hematology (01-02-2022)“…Health-related quality of life (HRQoL) is a multidimensional concept including physical, emotional, social, and cognitive functions, disease symptoms, and side…”
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Assessing the impact of taxon resolution on network structure
Published in Ecology (Durham) (01-03-2021)“…Constructing ecological networks has become an indispensable approach in understanding how different taxa interact. However, the methods used to generate data…”
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Performance of baseline FDG-PET/CT radiomics for prediction of bone marrow minimal residual disease status in the LyMa-101 trial
Published in Scientific reports (24-10-2023)“…The prognostic value of 18 F-Fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) at baseline or the predictive value of minimal…”
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A phase 2 study of rituximab, bendamustine, bortezomib and dexamethasone for first-line treatment of older patients with mantle cell lymphoma
Published in Haematologica (Roma) (01-01-2019)“…We present results of a prospective, multicenter, phase II study evaluating rituximab, bendamustine, bortezomib and dexamethasone as first-line treatment for…”
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Efficacy of a short sandwich protocol, methotrexate, gemcitabine, L‐asparaginase and dexamethasone chemotherapy combined with radiotherapy, in localised newly diagnosed NK/T‐cell lymphoma: A French retrospective study
Published in British journal of haematology (01-05-2023)“…Summary Extranodal NK/T‐cell lymphoma, nasal type is a rare and aggressive form of lymphoma, historically associated with poor prognosis. We report here the…”
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Intra- and interindividual variability in fasted gastric content volume
Published in Neurogastroenterology and motility (01-11-2024)“…Gastric fluid plays a key role in food digestion and drug dissolution, therefore, the amount of gastric fluid present in a fasted state may influence…”
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Pepsin activity as a function of pH and digestion time on caseins and egg white proteins under static in vitro conditions
Published in Food & function (13-12-2021)“…The activity of pepsin, the gastric protease, is generally considered to be negligible for pH ≥ 4, based on the results obtained with a few purified globular…”
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Machine-learning topology optimization with stochastic gradient descent optimizer for heat conduction problems
Published in International journal of heat and mass transfer (15-05-2024)“…•Utility of online-trained DNN to accelerate the density-based TO of heat conduction is studied.•A novel optimizer is developed by combing the optimality…”
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