Search Results - "Le, Nhat T. T."

Prions activate a p38 MAPK synaptotoxic signaling pathway by Fang, Cheng, Wu, Bei, Le, Nhat T T, Imberdis, Thibaut, Mercer, Robert C C, Harris, David A

“…Synaptic degeneration is one of the earliest pathological correlates of prion disease, and it is a major determinant of the progression of clinical symptoms…”
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Prion protein pathology in Ubiquilin 2 models of ALS by Le, Nhat T., Chu, Nam, Joshi, Gunjan, Higgins, Nicole R., Nebie, Ouada, Adelakun, Niyi, Butts, Marie, Monteiro, Mervyn J.

“…Mutations in UBQLN2 cause ALS and frontotemporal dementia (FTD). The pathological signature in UBQLN2 cases is deposition of highly unusual types of inclusions…”
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Prion neurotoxicity by Le, Nhat T. T., Wu, Bei, Harris, David A.

“…Although the mechanisms underlying prion propagation and infectivity are now well established, the processes accounting for prion toxicity and pathogenesis…”
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Synthetic prions with novel strain-specified properties by Moda, Fabio, Le, Thanh-Nhat T, Aulić, Suzana, Bistaffa, Edoardo, Campagnani, Ilaria, Virgilio, Tommaso, Indaco, Antonio, Palamara, Luisa, Andréoletti, Olivier, Tagliavini, Fabrizio, Legname, Giuseppe

“…Prions are infectious proteins that possess multiple self-propagating structures. The information for strains and structural specific barriers appears to be…”
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ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function by Wu, Josephine J., Cai, Ashley, Greenslade, Jessie E., Higgins, Nicole R., Fan, Cong, Le, Nhat T. T., Tatman, Micaela, Whiteley, Alexandra M., Prado, Miguel A., Dieriks, Birger V., Curtis, Maurice A., Shaw, Christopher E., Siddique, Teepu, Faull, Richard L. M., Scotter, Emma L., Finley, Daniel, Monteiro, Mervyn J.

“…Mutations in UBQLN2 cause amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other neurodegenerations. However, the mechanism by which the…”
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Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS–FTD-linked UBQLN2 mutations by Le, Nhat T. T., Chang, Lydia, Kovlyagina, Irina, Georgiou, Polymnia, Safren, Nathaniel, Braunstein, Kerstin E., Kvarta, Mark D., Van Dyke, Adam M., LeGates, Tara A., Philips, Thomas, Morrison, Brett M., Thompson, Scott M., Puche, Adam C., Gould, Todd D., Rothstein, Jeffrey D., Wong, Philip C., Monteiro, Mervyn J.

“…Missense mutations in ubiquilin 2 (UBQLN2) cause ALS with frontotemporal dementia (ALS–FTD). Animal models of ALS are useful for understanding the mechanisms…”
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Cellulose Aerogel from Paper Waste for Crude Oil Spill Cleaning by Nguyen, Son T, Feng, Jingduo, Le, Nhat T, Le, Ai T. T, Hoang, Nguyen, Tan, Vincent B. C, Duong, Hai M

“…Polyprolylene is commonly used for crude oil spill cleaning, but it has low absorption capacity and is nonbiodegradable. In our work, a green, ultralight, and…”
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Pretreatment Cerebrospinal Fluid Bacterial Load Correlates With Inflammatory Response and Predicts Neurological Events During Tuberculous Meningitis Treatment by Thuong, Nguyen T T, Vinh, Dao N, Hai, Hoang T, Thu, Do D A, Nhat, Le T H, Heemskerk, Dorothee, Bang, Nguyen D, Caws, Maxine, Mai, Nguyen T H, Thwaites, Guy E

“…In tuberculous meningitis (TBM), a higher pretreatment CSF bacterial load was associated with increased disease severity and host inflammation. The bacterial…”
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Sigma Receptor Ligands Are Potent Antiprion Compounds that Act Independently of Sigma Receptor Binding by Mercer, Robert C. C., Le, Nhat T. T., Fraser, Douglas G., Houser, Mei C. Q., Beeler, Aaron B., Harris, David A.

“…Prion diseases are invariably fatal neurodegenerative diseases of humans and other animals for which there are no effective treatment options. Previous work…”
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Functional outcome and muscle wasting in adults with tetanus by Trung, Truong N, Duoc, Nguyen V T, Nhat, Le T H, Yen, Lam M, Hao, Nguyen V, Truong, Nguyen T, Duong, Ha T H, Thuy, Duong B, Phong, Nguyen T, Tan, Le V, Puthucheary, Zudin A, Thwaites, C Louise

“…Abstract Background In many countries, in-hospital survival from tetanus is increasing, but long-term outcome is unknown. In high-income settings, critical…”
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Layout-aware expandable low-degree topology by Truong, Nguyen T., Nguyen, Van K., Le, Nhat T. X., Fujiwara, Ikki, Chaix, Fabien, Koibuchi, Michihiro

“…System expandability becomes a major concern for highly-parallel computers and datacenters, because their number of nodes gradually increases year by year. In…”
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Query by documents on top of a search interface by Le, Nhat X.T., Shahbazi, Moloud, Almaslukh, Abdulaziz, Hristidis, Vagelis

“…Document repositories often provide a keyword-based query interfaces to allow users to search for documents. These interfaces typically have rate limits or…”
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Abstract MP45: The Roles Of Telomeric Repeat Binding Factor 2-interacting Protein (TERF2IP) K240 Sumoylation In Endothelial Cells On Atherogenesis by Imanishi, Masaki, Velatooru, Loka, Ko, Kyung ae, Heo, Kyung-Sun, Thomas, Tamlyn, GI, YOUNG JIN, Fujiwara, Keigi, Le, Nhat T, Kotla, Sivareddy, Abe, Junichi

“…Abstract only Background and Objectives: It is not yet clear how the pro-atherogenic signaling events in endothelial cells (ECs) such as those that lead to EC…”
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Abnormal synaptic architecture in iPSC-derived neurons from a multi-generational family with genetic Creutzfeldt-Jakob disease by Gojanovich, Aldana D., Le, Nhat T.T., Mercer, Robert C.C., Park, Seonmi, Wu, Bei, Anane, Alice, Vultaggio, Janelle S., Mostoslavsky, Gustavo, Harris, David A.

“…Genetic prion diseases are caused by mutations in PRNP, which encodes the prion protein (PrPC). Why these mutations are pathogenic, and how they alter the…”
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Abstract 333: Tnik: A Novel Regulator Of Endothelial Interferon Signaling And Activation by Dominic, Abishai, Wang, Guangyu, Abe, Junichi, Le, Nhat Tu T

“…BackgroundEndothelial cells (ECs) are prominent cell types governing vascular tone and homeostasis. Activation of ECs is the central pathophysiological process…”
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Automatic Classification of Online Doctor Reviews: Evaluation of Text Classifier Algorithms by Rivas, Ryan, Montazeri, Niloofar, Le, Nhat Xt, Hristidis, Vagelis

“…An increasing number of doctor reviews are being generated by patients on the internet. These reviews address a diverse set of topics (features), including…”
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Interconnection networks with efficient custom routing, exploiting small-world effect by Le, Nhat T. X., Nguyen, Van K.

“…We design a new interconnection network topology and a custom routing algorithm, which targets solving new challenging issues posed by recent advanced studies…”
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Abstract 15362: Checkpoint Kinase 1-Associated Senp2 S344 Phosphorylation Under Laminar Flow Attenuates Endothelial-Mesenchymal Transition and Atherogenesis by Nguyen, Minh T, Imanishi, Masaki, Li, Shengyu, Ko, Kyung Ae, Banerjee, Priyanka, Velatooru, Loka reddy, McBeath, Elena, Fujiwara, Keigi, Kotla, Sivareddy, Chau, Khanh, Abe, Rei, borchardt, mae k, Yeh, Edward T, Cooke, John P, Wang, Guangyu, Abe, Junichi, Le, Nhat Tu T

“…AimsTo investigate the role of Checkpoint Kinase 1 (CHK1)-associated SENP2 S344 phosphorylation in laminar flow (LF)-regulated Endothelial-Mesenchymal…”
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Abstract 14719: Erk5 S496 Phosphorylation, but Not Erk5 Kinase Activation, Promotes Senescence-Associated Cell Growth (sacg) and Inflammation of Myeloid Cells and Atherosclerosis via Upregulating Sumoylation at a Novel Site (k518) on Nrf2 and Aryl Hydrocarbon Receptor by Kotla, Sivareddy, Imanishi, Masaki, Li, Shengyu, Zhang, Aijun, Ko, Kyung A, Samanthapudi, Venkata Subrahman K, Lee, Ling-Ling, Herrmann, Joerg, Lin, Steven, Shoykhet, Michael N, Shen, Ying H, Schadler, Keri, Nguyen, Minh T, Gupte, Anisha A, Reyes-Gibby, Cielito, Yeung, Sai-Ching, Palaskas, Nicolas L, Cooke, John P, Pownall, Henry J, Yoshimoto, Momoko, Fujiwra, Keigi, Hamilton, Dale, Burks, Jared K, Wang, Guangyu, Le, Nhat Tu T, Abe, Junichi

“…Senescence induced by various stresses reprograms cancer cells to acquire senescence-associated (SA) cell growth (SACG), which allows them to escape…”
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Distributed Shortcut Networks: Layout-Aware Low-Degree Topologies Exploiting Small-World Effect by Nguyen, Van K., Le, Nhat T. X., Fujiwara, Ikki, Koibuchi, Michihiro

“…Low communication latency becomes a main concern in highly parallel computers and supercomputers. Random network topologies are best to achieve low average…”
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