Search Results - "Le, Henry"

Dietary sphinganine is selectively assimilated by members of the mammalian gut microbiome by Lee, Min-Ting, Le, Henry H., Johnson, Elizabeth L.

“…Functions of the gut microbiome have a growing number of implications for host metabolic health, with diet being one of the most significant influences on…”
Get full text

Identification and characterization of 3-ketosphinganine reductase activity encoded at the BT_0972 locus in Bacteroides thetaiotaomicron by Lee, Min-Ting, Le, Henry, Besler, Kevin, Johnson, Elizabeth

“…Bacterial sphingolipid synthesis is important for the fitness of gut commensal bacteria with implied potential for regulating mammalian host physiology…”
Get full text

Host hepatic metabolism is modulated by gut microbiota-derived sphingolipids by Le, Henry H., Lee, Min-Ting, Besler, Kevin R., Johnson, Elizabeth L.

“…Microbially-derived gut metabolites are important contributors to host phenotypes, many of which may link microbiome composition to metabolic disease. However,…”
Get full text

A BOSSS method for managing insights into diet–microbiome interactions by Lee, Min-Ting, Le, Henry H., Johnson, Elizabeth L.

“…Gut microbial metabolites generated through interactions with dietary constituents are important modulators of host metabolism and physiology. Our…”
Get full text

Linking Genomic and Metabolomic Natural Variation Uncovers Nematode Pheromone Biosynthesis by Falcke, Jan M, Bose, Neelanjan, Artyukhin, Alexander B, Rödelsperger, Christian, Markov, Gabriel V, Yim, Joshua J, Grimm, Dominik, Claassen, Marc H, Panda, Oishika, Baccile, Joshua A, Zhang, Ying K, Le, Henry H, Jolic, Dino, Schroeder, Frank C, Sommer, Ralf J

“…In the nematodes Caenorhabditis elegans and Pristionchus pacificus, a modular library of small molecules control behavior, lifespan, and development. However,…”
Get more information

Going Keto? Say βHB-ye Bye to Your Gut Bifidobacteria by Le, Henry H, Johnson, Elizabeth L

“…Ketogenic diets (KDs) are popularly used to aid a myriad of conditions. KDs induce metabolic changes, but how microbiome alterations contribute to these…”
Get full text

Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer by Lukey, Michael J., Cluntun, Ahmad A., Katt, William P., Lin, Miao-chong J., Druso, Joseph E., Ramachandran, Sekar, Erickson, Jon W., Le, Henry H., Wang, Zhihan-Emily, Blank, Bryant, Greene, Kai Su, Cerione, Richard A.

“…Efforts to target glutamine metabolism for cancer therapy have focused on the glutaminase isozyme GLS. The importance of the other isozyme, GLS2, in cancer has…”
Get full text

Diketopiperazine Formation in Fungi Requires Dedicated Cyclization and Thiolation Domains by Baccile, Joshua A., Le, Henry H., Pfannenstiel, Brandon T., Bok, Jin Woo, Gomez, Christian, Brandenburger, Eileen, Hoffmeister, Dirk, Keller, Nancy P., Schroeder, Frank C.

“…Cyclization of linear dipeptidyl precursors derived from nonribosomal peptide synthetases (NRPSs) into 2,5‐diketopiperazines (DKPs) is a crucial step in the…”
Get full text

Multimodal high-resolution embryonic imaging with light sheet fluorescence microscopy and optical coherence tomography by Khajavi, Behzad, Sun, Ruijiao, Chawla, Harshdeep Singh, Le, Henry H, Singh, Manmohan, Schill, Alexander W, Dickinson, Mary E, Mayerich, David, Larin, Kirill V

“…A high-resolution imaging system combining optical coherence tomography (OCT) and light sheet fluorescence microscopy (LSFM) was developed. LSFM confined the…”
Get more information

Plant-like biosynthesis of isoquinoline alkaloids in Aspergillus fumigatus by Baccile, Joshua A, Spraker, Joseph E, Le, Henry H, Brandenburger, Eileen, Gomez, Christian, Bok, Jin Woo, Macheleidt, Juliane, Brakhage, Axel A, Hoffmeister, Dirk, Keller, Nancy P, Schroeder, Frank C

“…Analysis of orphan nonribosomal peptide synthetase–like gene clusters from Aspergillus fumigatus identified a gene cluster responsible for the biosynthesis of…”
Get full text

Estimating cost of road traffic injuries in Iran using willingness to pay (WTP) method by Ainy, Elaheh, Soori, Hamid, Ganjali, Mojtaba, Le, Henry, Baghfalaki, Taban

“…We aimed to use the willingness to pay (WTP) method to calculate the cost of traffic injuries in Iran in 2013. We conducted a cross-sectional…”
Get full text

Characterization of interactions of dietary cholesterol with the murine and human gut microbiome by Le, Henry H., Lee, Min-Ting, Besler, Kevin R., Comrie, Janine M. C., Johnson, Elizabeth L.

“…Consumption of dietary lipids, such as cholesterol, modulates the gut microbiome with consequences for host health through the production of microbiome-derived…”
Get full text

Parallel pathways for serotonin biosynthesis and metabolism in C. elegans by Yu, Jingfang, Vogt, Merly C., Fox, Bennett W., Wrobel, Chester J. J., Fajardo Palomino, Diana, Curtis, Brian J., Zhang, Bingsen, Le, Henry H., Tauffenberger, Arnaud, Hobert, Oliver, Schroeder, Frank C.

“…The neurotransmitter serotonin plays a central role in animal behavior and physiology, and many of its functions are regulated via evolutionarily conserved…”
Get full text

Prevotella copri variants among a single host diverge in sphingolipid production by Xiao, Xieyue, Le, Henry H, Lee, Min-Ting, Lamm, Daniel, Johnson, Elizabeth L, Brito, Ilana L

“…Sphingolipids serve as vital structural and signaling components of the cell membranes in both eukaryotes and prokaryotes. Within the gut microbiome, species…”
Get full text

Deep Interrogation of Metabolism Using a Pathway-Targeted Click-Chemistry Approach by Hoki, Jason S, Le, Henry H, Mellott, Karlie E, Zhang, Ying K, Fox, Bennett W, Rodrigues, Pedro R, Yu, Yan, Helf, Maximilian J, Baccile, Joshua A, Schroeder, Frank C

“…Untargeted metabolomics indicates that the number of unidentified small-molecule metabolites may exceed the number of protein-coding genes for many organisms,…”
Get full text

Antimicrobial Activity of Ibuprofen against Cystic Fibrosis-Associated Gram-Negative Pathogens by Shah, Parth N, Marshall-Batty, Kimberly R, Smolen, Justin A, Tagaev, Jasur A, Chen, Qingquan, Rodesney, Christopher A, Le, Henry H, Gordon, Vernita D, Greenberg, David E, Cannon, Carolyn L

“…Clinical trials have demonstrated the benefits of ibuprofen therapy in cystic fibrosis (CF) patients, an effect that is currently attributed to ibuprofen's…”
Get full text

Identification of Uric Acid Gluconucleoside–Ascaroside Conjugates in Caenorhabditis elegans by Combining Synthesis and MicroED by Curtis, Brian J, Kim, Lee Joon, Wrobel, Chester J. J, Eagan, James M, Smith, Rubin A, Burch, Jessica E, Le, Henry H, Artyukhin, Alexander B, Nelson, Hosea M, Schroeder, Frank C

“…Few nucleoside-derived natural products have been identified from animals, despite the ubiquity of nucleosides in living organisms. Here, we use a combination…”
Get full text

Publisher Correction: Parallel pathways for serotonin biosynthesis and metabolism in C. elegans by Yu, Jingfang, Vogt, Merly C., Fox, Bennett W., Wrobel, Chester J. J., Fajardo Palomino, Diana, Curtis, Brian J., Zhang, Bingsen, Le, Henry H., Tauffenberger, Arnaud, Hobert, Oliver, Schroeder, Frank C.

Get full text

Changes in Choline Metabolites and Ceramides in Response to a DASH-Style Diet in Older Adults by Tate, Brianna N, Van Guilder, Gary P, Aly, Marwa, Spence, Lisa A, Diaz-Rubio, M. Elena, Le, Henry H, Johnson, Elizabeth L, McFadden, Joseph W, Perry, Cydne A

“…This feeding trial evaluated the impact of the Dietary Approaches to Stop Hypertension diet on changes in plasma choline, choline metabolites, and ceramides in…”
Get full text

The 2021 Marine Pharmacology and Pharmaceuticals Pipeline by Wu, Alex C., Jelielek, Karolina K., Le, Henry Q., Butt, Maryam, Newman, David J., Glaser, Keith B., Pierce, Marsha L., Mayer, Alejandro M.

“…Objective Marine organisms continue providing significant chemical biodiversity that contributes to both the global preclinical and clinical pharmaceutical…”
Get full text