Search Results - "Le, Connie"
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Molecular Diagnosis of COVID-19: Challenges and Research Needs
Published in Analytical chemistry (Washington) (04-08-2020)“…Molecular diagnosis of COVID-19 primarily relies on the detection of RNA of the SARS-CoV-2 virus, the causative infectious agent of the pandemic. Reverse…”
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In Vitro Infection with Hepatitis B Virus Using Differentiated Human Serum Culture of Huh7.5-NTCP Cells without Requiring Dimethyl Sulfoxide
Published in Viruses (12-01-2021)“…An estimated two billion people worldwide have been infected with hepatitis B virus (HBV). Despite the high infectivity of HBV in vivo, a lack of easily…”
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Revealing the acute asthma ignorome: characterization and validation of uninvestigated gene networks
Published in Scientific reports (21-04-2016)“…Systems biology provides opportunities to fully understand the genes and pathways in disease pathogenesis. We used literature knowledge and unbiased multiple…”
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Acute lyme infection presenting with amyopathic dermatomyositis and rapidly fatal interstitial pulmonary fibrosis: a case report
Published in Journal of medical case reports (21-06-2010)“…Dermatomyositis has been described in the setting of lyme infection in only nine previous case reports. Although lyme disease is known to induce typical…”
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176 Combined Effects of Arsenic and Radiation
Published in Radiotherapy and oncology (01-09-2023)Get full text
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CRISPR technology incorporating amplification strategies: molecular assays for nucleic acids, proteins, and small molecules
Published in Chemical science (Cambridge) (08-04-2021)“…Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated (Cas) protein systems have transformed the field of genome editing and…”
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Eosinophilic gastroenteritis, ascites, and pancreatitis: A case report and review of the literature
Published in Southern medical journal (Birmingham, Ala.) (01-09-2004)“…Eosinophilic gastroenteritis is an inflammatory disorder of the gastrointestinal tract in which eosinophilic infiltration occurs in the gut layers. A case of…”
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177 Single Cell Rna Sequencing Characterization of an in Vitro Model for Studies of Hepatitis B Virus
Published in Radiotherapy and oncology (01-09-2023)Get full text
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A Genome-Editing Nanomachine Constructed with a Clustered Regularly Interspaced Short Palindromic Repeats System and Activated by Near-Infrared Illumination
Published in ACS nano (24-03-2020)“…The RNA-guided CRISPR/Cas9 system is a powerful genome-editing technology with broad applications. Improving delivery efficiency and controllable activity of…”
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An unusual case of a cervical mass due to nontuberculous mycobacterium fortuitum infection
Published in Permanente journal (01-01-2008)“…Mycobacterium fortuitum, of the class of nontuberculous mycobacteria, rarely causes cervical lymphadenopathy and head and neck masses. However, we treated a…”
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Aptamer Binding Assay for the E Antigen of Hepatitis B Using Modified Aptamers with G‑Quadruplex Structures
Published in Analytical chemistry (Washington) (05-05-2020)“…The e antigen of hepatitis B (HBeAg) is positively associated with an increased risk of developing liver cancer and cirrhosis in chronic hepatitis B (CHB)…”
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CRISPR Technique Incorporated with Single-Cell RNA Sequencing for Studying Hepatitis B Infection
Published in Analytical chemistry (Washington) (10-08-2021)“…Single-cell RNA sequencing (scRNA-seq) provides rich transcriptomic information for studying molecular events and cell heterogeneity at the single-cell level…”
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Targeting the Achilles heel of the hepatitis B virus: a review of current treatments against covalently closed circular DNA
Published in Drug discovery today (01-05-2015)“…•Chronic HBV infection is established as a result of the persistence of the cccDNA.•Current treatment strategies fail to cure HBV because they cannot eradicate…”
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Urban recreational water – potential breeding ground for antibiotic resistant bacteria?
Published in Journal of environmental sciences (China) (01-07-2019)Get full text
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CRISPR-Cas9 gene editing of hepatitis B virus in chronically infected humanized mice
Published in Molecular therapy. Methods & clinical development (12-03-2021)“…Chronic hepatitis B virus (HBV) infection is a major public health problem. New treatment approaches are needed because current treatments do not target…”
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A competitive displacement assay with quantum dots as fluorescence resonance energy transfer donors
Published in Analytica chimica acta (08-01-2013)“…[Display omitted] ► Demonstration of oligonucleotide displacement assay using quantum dots and FRET. ► Demonstration of a displacement assay that avoids…”
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Targeting the Achilles heel of the hepatitis B virus: a review of current treatments against covalently closed circular DNA: Keynote
Published in Drug discovery today (01-05-2015)“…Chronic infection with hepatitis B virus (HBV) often leads to the development of liver cancer and cirrhosis, creating immense sociological, clinical and…”
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Cervical myelopathy from spinal sarcoidosis as the unexpected initial presentation for systemic sarcoidosis
Published in Southern medical journal (Birmingham, Ala.) (01-09-2010)“…This is a case which highlights unique diagnostic challenges in the evaluation of a previously healthy patient presenting with a myelopathy initially most…”
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