Search Results - "Lazzeroni, Giulia"

siRNA screen identifies QPCT as a druggable target for Huntington's disease by Jimenez-Sanchez, Maria, Lam, Wun, Hannus, Michael, Sönnichsen, Birte, Imarisio, Sara, Fleming, Angeleen, Tarditi, Alessia, Menzies, Fiona, Ed Dami, Teresa, Xu, Catherine, Gonzalez-Couto, Eduardo, Lazzeroni, Giulia, Heitz, Freddy, Diamanti, Daniela, Massai, Luisa, Satagopam, Venkata P, Marconi, Guido, Caramelli, Chiara, Nencini, Arianna, Andreini, Matteo, Sardone, Gian Luca, Caradonna, Nicola P, Porcari, Valentina, Scali, Carla, Schneider, Reinhard, Pollio, Giuseppe, O'Kane, Cahir J, Caricasole, Andrea, Rubinsztein, David C

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siRNA screen identifies QPCT as a druggable target for Huntington's disease by Jimenez-Sanchez, Maria, Lam, Wun, Hannus, Michael, Sönnichsen, Birte, Imarisio, Sara, Fleming, Angeleen, Tarditi, Alessia, Menzies, Fiona, Ed Dami, Teresa, Xu, Catherine, Gonzalez-Couto, Eduardo, Lazzeroni, Giulia, Heitz, Freddy, Diamanti, Daniela, Massai, Luisa, Satagopam, Venkata P, Marconi, Guido, Caramelli, Chiara, Nencini, Arianna, Andreini, Matteo, Sardone, Gian Luca, Caradonna, Nicola P, Porcari, Valentina, Scali, Carla, Schneider, Reinhard, Pollio, Giuseppe, O'Kane, Cahir J, Caricasole, Andrea, Rubinsztein, David C

“…An siRNA screen for genes that suppress mutant huntingtin toxicity in both mammalian cells and Drosophila identifies glutaminyl cyclase (QPCT). Newly generated…”
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A phenotypic screening assay for modulators of huntingtin-induced transcriptional dysregulation by Lazzeroni, Giulia, Benicchi, Tiziana, Heitz, Freddy, Magnoni, Letizia, Diamanti, Daniela, Rossini, Lara, Massai, Luisa, Federico, Cesare, Fecke, Wolfgang, Caricasole, Andrea, La Rosa, Salvatore, Porcari, Valentina

“…Huntington's Disease is a rare neurodegenerative disease caused by an abnormal expansion of CAG repeats encoding polyglutamine in the first exon of the…”
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Fused 3‑Hydroxy-3-trifluoromethylpyrazoles Inhibit Mutant Huntingtin Toxicity by La Rosa, Salvatore, Benicchi, Tiziana, Bettinetti, Laura, Ceccarelli, Ilaria, Diodato, Enrica, Federico, Cesare, Fiengo, Pasquale, Franceschini, Davide, Gokce, Ozgun, Heitz, Freddy, Lazzeroni, Giulia, Luthi-Carter, Ruth, Magnoni, Letizia, Miragliotta, Vincenzo, Scali, Carla, Valacchi, Michela

“…Here, we describe the selection and optimization of a chemical series active in both a full-length and a fragment-based Huntington’s disease (HD) assay…”
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