Motor cortex changes in spinal cord injury: a TMS study

Using paired pulse transcranial magnetic stimulation (TMS) paradigms, we studied cortical excitability in a patient with spinal cord lesion. During posterior tibial nerve stimulation, the contextual flexion of hand fingers contralateral to the stimulated lower limb had suggested a change in motor co...

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Bibliographic Details
Published in:	Neurological research (New York) Vol. 30; no. 10; pp. 1084 - 1085
Main Authors:	Saturno, Eleonora, Bonato, Claudio, Miniussi, Carlo, Lazzaro, VincenzoDi, Callea, Leonardo
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 01-12-2008
Subjects:	Electric Stimulation - methods Electromyography Evoked Potentials, Motor - physiology Humans Motor Cortex - physiopathology MOTOR CORTEX PLASTICITY Spinal Cord Injuries - pathology Spinal Cord Injuries - therapy SPINAL CORD LESION Tibial Nerve - physiopathology TMS Transcranial Magnetic Stimulation - methods
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Summary:	Using paired pulse transcranial magnetic stimulation (TMS) paradigms, we studied cortical excitability in a patient with spinal cord lesion. During posterior tibial nerve stimulation, the contextual flexion of hand fingers contralateral to the stimulated lower limb had suggested a change in motor cortex excitability. Results showed a decrease in the activity of motor cortex inhibitory circuits. This could suggest that in spinal cord injury, just as in stroke and peripheral deafferentation, a disinhibition of latent synapses within the motor cortex and the rewriting of a new motor map can occur.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0161-6412 1743-1328
DOI:	10.1179/174313208X332968