Search Results - "Lazzarino, Giuseppe"

Modulation of Pro-Oxidant and Pro-Inflammatory Activities of M1 Macrophages by the Natural Dipeptide Carnosine by Fresta, Claudia G, Fidilio, Annamaria, Lazzarino, Giacomo, Musso, Nicolò, Grasso, Margherita, Merlo, Sara, Amorini, Angela M, Bucolo, Claudio, Tavazzi, Barbara, Lazzarino, Giuseppe, Lunte, Susan M, Caraci, Filippo, Caruso, Giuseppe

“…Carnosine is a natural endogenous dipeptide widely distributed in mammalian tissues, existing at particularly high concentrations in the muscles and brain and…”
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The Therapeutic Potential of Carnosine as an Antidote against Drug-Induced Cardiotoxicity and Neurotoxicity: Focus on Nrf2 Pathway by Caruso, Giuseppe, Privitera, Anna, Antunes, Barbara Moura, Lazzarino, Giuseppe, Lunte, Susan Marie, Aldini, Giancarlo, Caraci, Filippo

“…Different drug classes such as antineoplastic drugs (anthracyclines, cyclophosphamide, 5-fluorouracil, taxanes, tyrosine kinase inhibitors), antiretroviral…”
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Fusion or Fission: The Destiny of Mitochondria In Traumatic Brain Injury of Different Severities by Di Pietro, Valentina, Lazzarino, Giacomo, Amorini, Angela Maria, Signoretti, Stefano, Hill, Lisa J., Porto, Edoardo, Tavazzi, Barbara, Lazzarino, Giuseppe, Belli, Antonio

“…Mitochondrial dynamics are regulated by a complex system of proteins representing the mitochondrial quality control (MQC). MQC balances antagonistic forces of…”
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Metabolic, enzymatic and gene involvement in cerebral glucose dysmetabolism after traumatic brain injury by Amorini, Angela Maria, Lazzarino, Giacomo, Di Pietro, Valentina, Signoretti, Stefano, Lazzarino, Giuseppe, Belli, Antonio, Tavazzi, Barbara

“…In this study, the metabolic, enzymatic and gene changes causing cerebral glucose dysmetabolism following graded diffuse traumatic brain injury (TBI) were…”
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Altered Follicular Fluid Metabolic Pattern Correlates with Female Infertility and Outcome Measures of In Vitro Fertilization by Lazzarino, Giacomo, Pallisco, Romina, Bilotta, Gabriele, Listorti, Ilaria, Mangione, Renata, Saab, Miriam Wissam, Caruso, Giuseppe, Amorini, Angela Maria, Brundo, Maria Violetta, Lazzarino, Giuseppe, Tavazzi, Barbara, Bilotta, Pasquale

“…Nearly 40-50% of infertility problems are estimated to be of female origin. Previous studies dedicated to the analysis of metabolites in follicular fluid (FF)…”
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Pyruvate Dehydrogenase and Tricarboxylic Acid Cycle Enzymes Are Sensitive Targets of Traumatic Brain Injury Induced Metabolic Derangement by Lazzarino, Giacomo, Amorini, Angela Maria, Signoretti, Stefano, Musumeci, Giuseppe, Lazzarino, Giuseppe, Caruso, Giuseppe, Pastore, Francesco Saverio, Di Pietro, Valentina, Tavazzi, Barbara, Belli, Antonio

“…Using a closed-head impact acceleration model of mild or severe traumatic brain injury (mTBI or sTBI, respectively) in rats, we evaluated the effects of graded…”
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Glioblastoma mesenchymal subtype enhances antioxidant defence to reduce susceptibility to ferroptosis by D’Aprile, Simona, Denaro, Simona, Lavoro, Alessandro, Candido, Saverio, Giallongo, Sebastiano, Torrisi, Filippo, Salvatorelli, Lucia, Lazzarino, Giacomo, Amorini, Angela Maria, Lazzarino, Giuseppe, Magro, Gaetano, Tibullo, Daniele, Libra, Massimo, Giallongo, Cesarina, Vicario, Nunzio, Parenti, Rosalba

“…Glioblastoma (GBM) represents an aggressive brain tumor, characterized by intra- and inter-tumoral heterogeneity and therapy resistance, leading to…”
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Biochemical and neurochemical sequelae following mild traumatic brain injury: summary of experimental data and clinical implications by Signoretti, Stefano, Vagnozzi, Roberto, Tavazzi, Barbara, Lazzarino, Giuseppe

“…Although numerous studies have been carried out to investigate the pathophysiology of mild traumatic brain injury (mTBI), there are still no standard criteria…”
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Photobiomodulation reduces hippocampal apoptotic cell death and produces a Raman spectroscopic "signature" by Davies, David J, Hadis, Mohammed, Di Pietro, Valentina, Lazzarino, Giuseppe, Forcione, Mario, Harris, Georgia, Stevens, Andrew R, Soon, Wai Cheong, Goldberg Oppenheimer, Pola, Milward, Michael, Belli, Antonio, Palin, William M

“…Apoptotic cell death within the brain represents a significant contributing factor to impaired post-traumatic tissue function and poor clinical outcome after…”
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Antioxidant Therapies in Traumatic Brain Injury by Di Pietro, Valentina, Yakoub, Kamal M, Caruso, Giuseppe, Lazzarino, Giacomo, Signoretti, Stefano, Barbey, Aron K, Tavazzi, Barbara, Lazzarino, Giuseppe, Belli, Antonio, Amorini, Angela Maria

“…Due to a multiplicity of causes provoking traumatic brain injury (TBI), TBI is a highly heterogeneous pathology, characterized by high mortality and disability…”
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A phase II open label clinical study of the safety, tolerability and efficacy of ILB® for Amyotrophic Lateral Sclerosis by Logan, Ann, Nagy, Zsuzsanna, Barnes, Nicholas M, Belli, Antonio, Di Pietro, Valentina, Tavazzi, Barbara, Lazzarino, Giuseppe, Lazzarino, Giacomo, Bruce, Lars, Persson, Lennart I

“…Amyotrophic lateral sclerosis (ALS) is an invariably lethal progressive disease, causing degeneration of neurons and muscle. No current treatment halts or…”
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Bilirubin Concentration in Follicular Fluid Is Increased in Infertile Females, Correlates with Decreased Antioxidant Levels and Increased Nitric Oxide Metabolites, and Negatively Affects Outcome Measures of In Vitro Fertilization by Mangione, Renata, Pallisco, Romina, Bilotta, Gabriele, Marroni, Francesca, Di Pietro, Valentina, Capoccia, Elena, Lazzarino, Giuseppe, Tavazzi, Barbara, Lazzarino, Giacomo, Bilotta, Pasquale, Amorini, Angela Maria

“…In a previous study, we showed that various low-molecular-weight compounds in follicular fluid (FF) samples of control fertile females (CFF) have different…”
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Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Cells: A Key Role of TGF-β1 by Caruso, Giuseppe, Fresta, Claudia G, Musso, Nicolò, Giambirtone, Mariaconcetta, Grasso, Margherita, Spampinato, Simona F, Merlo, Sara, Drago, Filippo, Lazzarino, Giuseppe, Sortino, Maria A, Lunte, Susan M, Caraci, Filippo

“…Carnosine (β-alanyl-L-histidine), a dipeptide, is an endogenous antioxidant widely distributed in excitable tissues like muscles and the brain. Carnosine is…”
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(+)-Lipoic Acid Reduces Lipotoxicity and Regulates Mitochondrial Homeostasis and Energy Balance in an In Vitro Model of Liver Steatosis by Longhitano, Lucia, Distefano, Alfio, Amorini, Angela Maria, Orlando, Laura, Giallongo, Sebastiano, Tibullo, Daniele, Lazzarino, Giuseppe, Nicolosi, Anna, Alanazi, Amer M., Saoca, Concetta, Macaione, Vincenzo, Aguennouz, M’hammed, Salomone, Federico, Tropea, Emanuela, Barbagallo, Ignazio Alberto, Volti, Giovanni Li, Lazzarino, Giacomo

“…Non-alcoholic fatty liver disease (NAFLD) is characterized by the accumulation of lipids within hepatocytes, which compromises liver functionality following…”
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(+)-Lipoic acid reduces mitochondrial unfolded protein response and attenuates oxidative stress and aging in an in vitro model of non-alcoholic fatty liver disease by Longhitano, Lucia, Distefano, Alfio, Musso, Nicolò, Bonacci, Paolo, Orlando, Laura, Giallongo, Sebastiano, Tibullo, Daniele, Denaro, Simona, Lazzarino, Giuseppe, Ferrigno, Jessica, Nicolosi, Anna, Alanazi, Amer M, Salomone, Federico, Tropea, Emanuela, Barbagallo, Ignazio Alberto, Bramanti, Vincenzo, Li Volti, Giovanni, Lazzarino, Giacomo, Torella, Daniele, Amorini, Angela Maria

“…Non-alcoholic fatty liver disease (NAFLD) is a liver disorder characterized by the ac-cumulation of fat in hepatocytes without alcohol consumption…”
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Metabolic Signature of Energy Metabolism Alterations and Excess Nitric Oxide Production in Culture Media Correlate with Low Human Embryo Quality and Unsuccessful Pregnancy by Pallisco, Romina, Lazzarino, Giacomo, Bilotta, Gabriele, Marroni, Francesca, Mangione, Renata, Saab, Miriam Wissam, Brundo, Maria Violetta, Pittalà, Alessandra, Caruso, Giuseppe, Capoccia, Elena, Lazzarino, Giuseppe, Tavazzi, Barbara, Bilotta, Pasquale, Amorini, Angela Maria

“…Notwithstanding the great improvement of ART, the overall rate of successful pregnancies from implanted human embryos is definitely low. The current routine…”
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Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load by Takimoto, Eiki, Champion, Hunter C, Li, Manxiang, Ren, Shuxun, Rodriguez, E Rene, Tavazzi, Barbara, Lazzarino, Giuseppe, Paolocci, Nazareno, Gabrielson, Kathleen L, Wang, Yibin, Kass, David A

“…Cardiac pressure load stimulates hypertrophy, often leading to chamber dilation and dysfunction. ROS contribute to this process. Here we show that uncoupling…”
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The Pathophysiology of Concussion by Signoretti, Stefano, MD, PhD, Lazzarino, Giuseppe, PhD, Tavazzi, Barbara, PhD, Vagnozzi, Roberto, MD, PhD

“…Abstract Concussion is defined as a biomechanically induced brain injury characterized by the absence of gross anatomic lesions. Early and late clinical…”
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ILB®, a Low Molecular Weight Dextran Sulphate, Restores Glutamate Homeostasis, Amino Acid Metabolism and Neurocognitive Functions in a Rat Model of Severe Traumatic Brain Injury by Lazzarino, Giacomo, Di Pietro, Valentina, Rinaudo, Marco, Nagy, Zsuzsanna, Barnes, Nicholas M., Bruce, Lars, Signoretti, Stefano, Mangione, Renata, Saab, Miriam Wissam, Tavazzi, Barbara, Belli, Antonio, Lazzarino, Giuseppe, Amorini, Angela Maria, Logan, Ann

“…In a previous study, we found that administration of ILB®, a new low molecular weight dextran sulphate, significantly improved mitochondrial functions and…”
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Carnosine Decreases PMA-Induced Oxidative Stress and Inflammation in Murine Macrophages by Caruso, Giuseppe, Fresta, Claudia G, Fidilio, Annamaria, O'Donnell, Fergal, Musso, Nicolò, Lazzarino, Giacomo, Grasso, Margherita, Amorini, Angela M, Tascedda, Fabio, Bucolo, Claudio, Drago, Filippo, Tavazzi, Barbara, Lazzarino, Giuseppe, Lunte, Susan M, Caraci, Filippo

“…Carnosine is an endogenous dipeptide composed of β-alanine and L-histidine. This naturally occurring molecule is present at high concentrations in several…”
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