Search Results - "Lazo, Suzan"

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors by Villani, Alexandra-Chloé, Satija, Rahul, Reynolds, Gary, Sarkizova, Siranush, Shekhar, Karthik, Fletcher, James, Griesbeck, Morgane, Butler, Andrew, Zheng, Shiwei, Lazo, Suzan, Jardine, Laura, Dixon, David, Stephenson, Emily, Nilsson, Emil, Grundberg, Ida, McDonald, David, Filby, Andrew, Li, Weibo, De Jager, Philip L., Rozenblatt-Rosen, Orit, Lane, Andrew A., Haniffa, Muzlifah, Regev, Aviv, Hacohen, Nir

“…Dendritic cells (DCs) and monocytes play a central role in pathogen sensing, phagocytosis, and antigen presentation and consist of multiple specialized…”
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PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer by Ding, Liya, Kim, Hye-Jung, Wang, Qiwei, Kearns, Michael, Jiang, Tao, Ohlson, Carolynn E., Li, Ben B., Xie, Shaozhen, Liu, Joyce F., Stover, Elizabeth H., Howitt, Brooke E., Bronson, Roderick T., Lazo, Suzan, Roberts, Thomas M., Freeman, Gordon J., Konstantinopoulos, Panagiotis A., Matulonis, Ursula A., Zhao, Jean J.

“…PARP inhibitors have shown promising clinical activities for patients with BRCA mutations and are changing the landscape of ovarian cancer treatment. However,…”
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Immunomodulation of NK, NKT and B/T cell subtypes in relapsed/refractory multiple myeloma patients treated with pomalidomide along with velcade and dexamethasone and its association with improved progression-free survival by Prabhala, Rao, Pierceall, William E, Samur, Mehmet, Potluri, Lakshmi B, Hong, Kevin, Peluso, Teresa, Talluri, Srikanth, Wang, Angela, Katiki, Aishwarya, Vangala, Sahan D, Buonopane, Michael, Bade, Vaishnavi, Seah, Hannah, Krogman, Arthur, Derebail, Sanika, Fulciniti, Mariateresa, Lazo, Suzan B, Richardson, Paul, Anderson, Kenneth, Corre, Jill, Avet-Loiseau, Herve, Thakurta, Anjan, Munshi, Nikhil

“…Multiple Myeloma (MM) patients exhibit dysregulated immune system, which is further weakened by chemotherapeutic agents. While cereblon-modulating agents, such…”
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Development of an 8-color antibody panel for functional phenotyping of human CD8+ cytotoxic T cells from peripheral blood mononuclear cells by Patel, Tara, Cunningham, Amy, Holland, Martha, Daley, John, Lazo, Suzan, Hodi, F. Stephen, Severgnini, Mariano

“…The study of CD8 positive cells in peripheral blood has become an essential part of research in the field of cancer immunotherapies, vaccine development,…”
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FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress by Tothova, Zuzana, Kollipara, Ramya, Huntly, Brian J., Lee, Benjamin H., Castrillon, Diego H., Cullen, Dana E., McDowell, Elizabeth P., Lazo-Kallanian, Suzan, Williams, Ifor R., Sears, Christopher, Armstrong, Scott A., Passegué, Emmanuelle, DePinho, Ronald A., Gilliland, D. Gary

“…To understand the role of FoxO family members in hematopoiesis, we conditionally deleted FoxO1, FoxO3, and FoxO4 in the adult hematopoietic system…”
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Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenström macroglobulinemia by Moreau, Anne-Sophie, Jia, Xiaoying, Ngo, Hai T., Leleu, Xavier, O'Sullivan, Garrett, Alsayed, Yazan, Leontovich, Alexey, Podar, Klaus, Kutok, Jeffrey, Daley, John, Lazo-Kallanian, Suzan, Hatjiharissi, Evdoxia, Raab, Marc S., Xu, Lian, Treon, Steven P., Hideshima, Teru, Anderson, Kenneth C., Ghobrial, Irene M.

“…Waldenström macroglobulinemia (WM) is an incurable lymphoplasmacytic lymphoma with limited options of therapy. Protein kinase Cβ (PKCβ) regulates cell survival…”
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Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages by Guerriero, Jennifer L., Sotayo, Alaba, Ponichtera, Holly E., Castrillon, Jessica A., Pourzia, Alexandra L., Schad, Sara, Johnson, Shawn F., Carrasco, Ruben D., Lazo, Suzan, Bronson, Roderick T., Davis, Scott P., Lobera, Mercedes, Nolan, Michael A., Letai, Anthony

“…A selective class IIa histone deacetylase inhibitor induces anti-tumour immunity in a mouse model of mammary cancer through altered differentiation and…”
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Enhanced Efficacy of Simultaneous PD-1 and PD-L1 Immune Checkpoint Blockade in High-Grade Serous Ovarian Cancer by Wan, Changxin, Keany, Matthew P, Dong, Han, Al-Alem, Linah F, Pandya, Unnati M, Lazo, Suzan, Boehnke, Karsten, Lynch, Katherine N, Xu, Rui, Zarrella, Dominique T, Gu, Shengqing, Cejas, Paloma, Lim, Klothilda, Long, Henry W, Elias, Kevin M, Horowitz, Neil S, Feltmate, Colleen M, Muto, Michael G, Worley, Jr, Michael J, Berkowitz, Ross S, Matulonis, Ursula A, Nucci, Marisa R, Crum, Christopher P, Rueda, Bo R, Brown, Myles, Liu, Xiaole Shirley, Hill, Sarah J

“…Immune therapies have had limited efficacy in high-grade serous ovarian cancer (HGSC), as the cellular targets and mechanism(s) of action of these agents in…”
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OP01-5 Combination immunotherapy targeting XBP1, CD138 and CS1 with cancer vaccine, checkpoint inhibitors, immune modulator, and epigenetic regulator to treat patients with myeloma or solid tumours: Clinical applications by Bae, Jooeun, Cowens, Kristen, Kimmelman, Alec, Rowell, Sean, Lazo, Suzan, Keskin, Derin, Munshi, Nikhil, Anderson, Kenneth

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Characterization of midostaurin as a dual inhibitor of FLT3 and SYK and potentiation of FLT3 inhibition against FLT3-ITD-driven leukemia harboring activated SYK kinase by Weisberg, Ellen L, Puissant, Alexandre, Stone, Richard, Sattler, Martin, Buhrlage, Sara J, Yang, Jing, Manley, Paul W, Meng, Chengcheng, Buonopane, Michael, Daley, John F, Lazo, Suzan, Wright, Renee, Weinstock, David M, Christie, Amanda L, Stegmaier, Kimberly, Griffin, James D

“…Oncogenic FLT3 kinase is a clinically validated target in acute myeloid leukemia (AML), and both multi-targeted and selective FLT3 inhibitors have been…”
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Class IIa HDAC inhibition reduces breast tumors and metastases via anti-tumor macrophages by Guerriero, Jennifer L., Sotayo, Alaba, Ponichtera, Holly E., Castrillon, Jessica A., Pourzia, Alexandra L., Schad, Sara, Johnson, Shawn F., Carrasco, Ruben D., Lazo, Suzan, Bronson, Roderick T., Davis, Scott P., Lobera, Mercedes, Nolan, Michael A., Letai, Anthony

“…Although the main focus of immuno-oncology has been on manipulating the adaptive immune system, harnessing both the innate and adaptive arms of the immune…”
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Essential role for the p55 tumor necrosis factor receptor in regulating hematopoiesis at a stem cell level by Rebel, V I, Hartnett, S, Hill, G R, Lazo-Kallanian, S B, Ferrara, J L, Sieff, C A

“…Hematopoietic stem cell (HSC) self-renewal is a complicated process, and its regulatory mechanisms are poorly understood. Previous studies have identified…”
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Favorable Progression-Free Survival Associated with Immune Bio-Markers Modulated By Pomalidomide in Relapsed/Refractory Multiple Myeloma: An Analysis of Phase III Study by Prabhala, Rao, Samur, Mehmet Kemal, Talluri, Srikanth, Stekla, Megan, Yenumula, Chaitanya, Lopez, Michael A, Derebail, Sanika, Potluri, Lakshmi B., Wang, Angela, Katiki, Aishwarya, Vangala, Sahan D., Haas, Eric, Buonopane, Michael J, Heubeck, Alexander T, Fulciniti, Mariateresa, Szalat, Raphael, Lazo-Kallanian, Suzan, Hong, Kevin, Peluso, Teresa, Daley, John, Biyukov, Tsvetan, Oriol, Albert, Pierceall, William E., Richardson, Paul G., Anderson, Kenneth C., Thakurta, Anjan, Avet-Loiseau, Hervé, Munshi, Nikhil C.

“…We have previously shown that immune cells, including regulatory T cells, Th17 cells, myeloid-derived suppressor cells and NK cells are abnormal in multiple…”
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Perturbation in B Cell-Subsets Can Explain the Observed Suppression of Uninvolved Immunoglobulins and Their Impact on T Tell-Subsets As Well As Patients Outcome in Myeloma by Prabhala, Rao, Acharya, Shree, Stekla, Megan, Talluri, Srikanth, Szalat, Raphael, Nanjappa, Puru, Lopez, Michael A, Wen, Kenneth, Yenumula, Chaitanya, Heubeck, Alexander, Tai, Yu-Tzu, Mehta, Ansh, Fulciniti, Mariateresa, Lazo-Kallanian, Suzan, Daley, John, Richardson, Paul G, Anderson, Kenneth C, Munshi, Nikhil

“…Multiple myeloma (MM), a plasma cell malignancy, is associated with immune dysfunction influenced by both direct and an indirect interaction between MM cells…”
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LGG-05. SINGLE-CELL RNA SEQUENCING OF PEDIATRIC LOW-GRADE GLIOMAS REVEALS INTRATUMORAL HETEROGENEITY by Paolella, Brenton, Bandopadhayay, Pratiti, Bergthold, Guillaume, Shalek, Alex, Pelton, Kristine, Ramkissoon, Shakti, Sinai, Claire, Malkin, Hayley, Herbert, Zach, Sun, Yu, Alberta, John, Brown, Meredith, Daley, John, Lazo-Kallanian, Suzan, Goumnerova, Liliana, Kieran, Mark, Ligon, Keith, Beroukhim, Rameen

“…Pediatric low-grade gliomas (PLGGs) are slow growing tumors that result in neurologic defects due to both disease burden and therapeutic complications. We have…”
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Modulation of NK, T, & B cell sub-populations by Pomalidomide predicts favorable progression-free survival (PFS): Results from a large randomized clinical trial in relapsed/refractory myeloma by Rao, Prabhal, Samur, Mehmet, Talluri, Srikanth, Derebail, Sanika, Potluri, Lakshmi, Haas, Eric, Buonopane, Michael, Heubeck, Alexander, Fulciniti, Mariateresa, Lazo-Kallanian, Suzan, Hong, Kevin, Peluso, Teresa, john daley, Biyukov, Tsvetan, Beksac, Meral, Dimopoulos, Meletios A., mohamad hussain, Pierceall, William, Richardson, Paul G., Anderson, Kenneth C., Thakurta, Anjan, Avet-Loiseau, Herve, Munshi, Nikhil

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Homeostatic Reconstitution of CD4+ Regulatory and Conventional T Cell Subsets in Adult Patients after Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) by Alho, Ana Cristina, Haesook, Kim T, Reynolds, Carol G, Chammas, Marie J, McDonough, Sean, Lazo-Kallanian, Suzan, Daley, John, Nikiforow, Sarah, Cutler, Corey S, Koreth, John, Ho, Vincent T, Armand, Philippe, Soiffer, Robert J., Antin, Joseph H, Ritz, Jerome

“…Reconstitution of T cell function after allogeneic HSCT is dependent on the balanced recovery of CD4+Foxp3+ regulatory T cells (Treg) and CD4+Foxp3-…”
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Genome-Wide Aberrant Splicing in Patients with Acute Myelold Leukemia (AML) Is Associated with Altered Expression of Splicing Factors by Adamia, Sophia, Avet-Loiseau, Hervé, Jakubikova, Jana, Lazo-Kallanian, Suzan, Daley, John, Lode, Laurence, Galinsky, Ilene, Stone, Richard M., Griffin, James D.

“…Abstract 652 Long-term survival of patients with acute myeloid leukemia (AML) is poor, and new forms of therapy are needed. Many genetic lesions have been…”
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Multiple Myeloma Cells Express IL-17A Creating An Autocrine Loop: An Attractive Therapeutic Target by Prabhala, Rao H., Fulcinitti, Mariateresa, Pelluru, Dheeraj, Prabhala, Harsha K., Rashid, Naim, Sperling, Adam, Nanjappa, Puru, Lee, Saem, Negroiu, Andreea, Lazo-Kallanian, Suzan, Munshi, Aditya, Richardson, Paul G., Daley, John, Anderson, Kenneth C., Munshi, Nikhil C.

“…We have previously demonstrated that Th17 cells, which produce IL-17A, are significantly elevated in peripheral blood and bone marrow (BM) of patients with…”
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Low-Dose IL-2 Induces Bcl2 Expression and Resistance To Apoptosis In CD4 Regulatory T Cells by Murase, Kazuyuki, Kawano, Yutaka, Ryan, Jeremy, Matsuoka, Ken-ichi, Bascug, Gregory, McDonough, Sean, Smith, Robert W, Cowens, Kristen, Lazo-Kallanian, Suzan, Daley, John, Koreth, John, Soiffer, Robert J., Letai, Anthony, Ritz, Jerome

“…CD4+CD25+Foxp3+ regulatory T cells (Treg) play an important role in the maintenance of self-tolerance and immune homeostasis. Interleukin-2 (IL-2) is critical…”
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