Search Results - "Lazo, Pedro"

Signal transduction by tumor necrosis factor receptors by Cabal-Hierro, Lucía, Lazo, Pedro S.

“…Tumor necrosis factor (TNF) is a key mediator in the inflammatory response which is implicated in the onset of a number of diseases. Research on TNF led to the…”
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Reverting p53 activation after recovery of cellular stress to resume with cell cycle progression by Lazo, Pedro A.

“…The activation of p53 in response to different types of cellular stress induces several protective reactions including cell cycle arrest, senescence or cell…”
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VRK1 Kinase Activity Modulating Histone H4K16 Acetylation Inhibited by SIRT2 and VRK-IN-1 by Monte-Serrano, Eva, Lazo, Pedro A

“…The accessibility of DNA to different cellular functions requires a dynamic regulation of chromatin organization that is mediated by different epigenetic…”
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Implication of the VRK1 chromatin kinase in the signaling responses to DNA damage: a therapeutic target? by Campillo-Marcos, Ignacio, Lazo, Pedro A.

“…DNA damage causes a local distortion of chromatin that triggers the sequential processes that participate in specific DNA repair mechanisms. This initiation of…”
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Nuclear functions regulated by the VRK1 kinase by Lazo, Pedro A

“…In the nucleus, the VRK1 Ser-Thr kinase is distributed in nucleoplasm and chromatin, where it has different roles. VRK1 expression increases in response to…”
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Targeting Histone Epigenetic Modifications and DNA Damage Responses in Synthetic Lethality Strategies in Cancer? by Lazo, Pedro A

“…Synthetic lethality strategies are likely to be integrated in effective and specific cancer treatments. These strategies combine different specific targets,…”
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VRK1 variants at the cross road of Cajal body neuropathogenic mechanisms in distal neuropathies and motor neuron diseases by Lazo, Pedro A., Morejón-García, Patricia

“…Distal hereditary neuropathies and neuro motor diseases are complex neurological phenotypes associated with pathogenic variants in a large number of genes, but…”
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Functional implications of tetraspanin proteins in cancer biology by Lazo, Pedro A.

“…Human tetraspanin proteins are a group of 33 highly hydrophobic membrane proteins that can form complexes in cholesterol‐rich microdomains, distinct from lipid…”
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Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase by Campillo-Marcos, Ignacio, Lazo, Pedro A

“…The VRK1 chromatin kinase regulates the organization of locally altered chromatin induced by DNA damage. The combination of ionizing radiation with inhibitors…”
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The human VRK1 chromatin kinase in cancer biology by Campillo-Marcos, Ignacio, García-González, Raúl, Navarro-Carrasco, Elena, Lazo, Pedro A.

“…VRK1 is a nuclear Ser-Thr chromatin kinase that does not mutate in cancer, and is overexpressed in many types of tumors and associated with a poor prognosis…”
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Is Centrosomal Protein 70, a Centrosomal Protein with New Roles in Breast Cancer Dissemination and Metastasis, a Facilitator of Epithelial-Mesenchymal Transition? by Lazo, Pedro A

“…This commentary highlights the article by Shi et al that identified centrosomal protein 70 as a key mediator of breast cancer growth and metastasis…”
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Human VRK1 is an early response gene and its loss causes a block in cell cycle progression by Valbuena, Alberto, López-Sánchez, Inmaculada, Lazo, Pedro A

“…In mammalian cells regulatory proteins controlling the cell cycle are necessary due to the requirements of living in a heterogeneous environment of…”
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Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway by Valbuena, Alberto, Castro-Obregón, Susana, Lazo, Pedro A

“…Human VRK1 induces a stabilization and accumulation of p53 by specific phosphorylation in Thr18. This p53 accumulation is reversed by its downregulation…”
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VRK1 functional insufficiency due to alterations in protein stability or kinase activity of human VRK1 pathogenic variants implicated in neuromotor syndromes by Martín-Doncel, Elena, Rojas, Ana M., Cantarero, Lara, Lazo, Pedro A.

“…Very rare polymorphisms in the human VRK1 (vaccinia-related kinase 1) gene have been identified in complex neuromotor phenotypes associated to spinal muscular…”
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VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis by Moura, David S., Campillo-Marcos, Ignacio, Vázquez-Cedeira, Marta, Lazo, Pedro A.

“…Regulation of cell division requires the integration of signals implicated in chromatin reorganization and coordination of its sequential changes in mitosis…”
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The VRK1 chromatin kinase regulates the acetyltransferase activity of Tip60/KAT5 by sequential phosphorylations in response to DNA damage by García-González, Raúl, Monte-Serrano, Eva, Morejón-García, Patricia, Navarro-Carrasco, Elena, Lazo, Pedro A.

“…The regulation of histone epigenetic modifications mediates the adaptation of chromatin to different biological processes. DNA damage causes a local relaxation…”
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VRK1 Depletion Facilitates the Synthetic Lethality of Temozolomide and Olaparib in Glioblastoma Cells by Navarro-Carrasco, Elena, Lazo, Pedro A

“…Glioblastomas treated with temozolomide frequently develop resistance to pharmacological treatments. Therefore, there is a need to find alternative drug…”
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Pathogenic effects of Leu200Pro and Arg387His VRK1 protein variants on phosphorylation targets and H4K16 acetylation in distal hereditary motor neuropathy by Campos-Díaz, Aurora, Morejón-García, Patricia, Monte-Serrano, Eva, Ros-Pardo, David, Marcos-Alcalde, Iñigo, Gómez-Puertas, Paulino, Lazo, Pedro A.

“…Rare recessive variants in the human VRK1 gene are associated with several motor neuron diseases (MND), such as amyotrophic lateral sclerosis, spinal muscular…”
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VRK1 Regulates Sensitivity to Oxidative Stress by Altering Histone Epigenetic Modifications and the Nuclear Phosphoproteome in Tumor Cells by Navarro-Carrasco, Elena, Monte-Serrano, Eva, Campos-Díaz, Aurora, Rolfs, Frank, de Goeij-de Haas, Richard, Pham, Thang V, Piersma, Sander R, González-Alonso, Paula, Jiménez, Connie R, Lazo, Pedro A

“…The chromatin organization and its dynamic remodeling determine its accessibility and sensitivity to DNA damage oxidative stress, the main source of endogenous…”
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VRK1 phosphorylates and protects NBS1 from ubiquitination and proteasomal degradation in response to DNA damage by Monsalve, Diana M., Campillo-Marcos, Ignacio, Salzano, Marcella, Sanz-García, Marta, Cantarero, Lara, Lazo, Pedro A.

“…NBS1 is an early component in DNA-Damage Response (DDR) that participates in the initiation of the responses aiming to repair double-strand breaks caused by…”
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