Search Results - "Lazo, Noel D"

Inhibition of the Self-Assembly of Aβ and of Tau by Polyphenols: Mechanistic Studies by Zheng, Qiuchen, Kebede, Micheal T, Kemeh, Merc M, Islam, Saadman, Lee, Bethany, Bleck, Stuart D, Wurfl, Liliana A, Lazo, Noel D

“…The amyloid-β (Aβ) peptide and tau protein are thought to play key neuropathogenic roles in Alzheimer's disease (AD). Both Aβ and tau self-assemble to form the…”
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Highly toxic Aβ begets more Aβ by Kemeh, Merc M, Lazo, Noel D

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Familial Alzheimer's disease mutations alter the stability of the amyloid β-protein monomer folding nucleus by Grant, Marianne A, Lazo, Noel D, Lomakin, Aleksey, Condron, Margaret M, Arai, Hiromi, Yamin, Ghiam, Rigby, Alan C, Teplow, David B

“…Amyloid β-protein (Aβ) oligomers may be the proximate neurotoxins in Alzheimer's disease (AD). Recently, to elucidate the oligomerization pathway, we studied…”
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Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme by Ivancic, Valerie A, Krasinski, Claire A, Zheng, Qiuchen, Meservier, Rebecca J, Spratt, Donald E, Lazo, Noel D

“…Insulin-degrading enzyme (IDE) is a zinc metalloprotease that selectively degrades biologically important substrates associated with type 2 diabetes and…”
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K114 (trans, trans)‐bromo‐2,5‐bis(4‐hydroxystyryl)benzene is an efficient detector of cationic amyloid fibrils by Selmani, Veli, Robbins, Kevin J., Ivancic, Valerie A., Lazo, Noel D.

“…Cationic amyloid fibrils found in human semen enhance the transmission of the human immunodeficiency virus (HIV) and thus, are named semen‐derived enhancer of…”
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Mechanistic Studies of the Inhibition of Insulin Fibril Formation by Rosmarinic Acid by Zheng, Qiuchen, Lazo, Noel D

“…The self-assembly of insulin to form amyloid fibrils has been widely studied because it is a significant problem in the medical management of diabetes and is…”
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Resveratrol Sustains Insulin-Degrading Enzyme Activity toward Aβ42 by Krasinski, Claire A, Ivancic, Valerie A, Zheng, Qiuchen, Spratt, Donald E, Lazo, Noel D

“…Alzheimer’s disease (AD), the most common cause of dementia in the elderly, is the sixth leading cause of death in the United States. We hypothesize that the…”
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Solvent and Mutation Effects on the Nucleation of Amyloid β-Protein Folding by Cruz, Luis, Urbanc, Brigita, Borreguero, Jose M., Lazo, Noel D., Teplow, David B., Stanley, H. Eugene

“…Experimental evidence suggests that the folding and aggregation of the amyloid $\beta-protein$ (Aβ) into oligomers is a key pathogenetic event in Alzheimer's…”
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Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-Degrading Enzyme by Zheng, Qiuchen, Kebede, Micheal T, Lee, Bethany, Krasinski, Claire A, Islam, Saadman, Wurfl, Liliana A, Kemeh, Merc M, Ivancic, Valerie A, Jakobsche, Charles E, Spratt, Donald E, Lazo, Noel D

“…The insulin-degrading enzyme (IDE) possesses a strong ability to degrade insulin and Aβ42 that has been linked to the neurodegeneration in Alzheimer's disease…”
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Folding Events in the 21-30 Region of Amyloid β-Protein (Aβ) Studied in silico by Borreguero, Jose M., Urbanc, Brigita, Lazo, Noel D., Buldyrev, Sergey V., Teplow, David B., Stanley, H. Eugene

“…Oligomeric assemblies of the amyloid β-protein (Aβ) have been implicated in the pathogenesis of Alzheimer's disease as a primary source of neurotoxicity…”
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Helix Dipole and Membrane Electrostatics Delineate Conformational Transitions in the Self-Assembly of Amyloidogenic Peptides by Zheng, Qiuchen, Carty, Senegal N, Lazo, Noel D

“…The self-assembly of amyloidogenic peptides on membrane surfaces is associated with the death of neurons and β-cells in Alzheimer’s disease and type 2…”
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Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease by Bowers, Michael T, Bernstein, Summer L, Dupuis, Nicholas F, Lazo, Noel D, Wyttenbach, Thomas, Condron, Margaret M, Bitan, Gal, Teplow, David B, Shea, Joan-Emma, Ruotolo, Brandon T, Robinson, Carol V

“…In recent years, small protein oligomers have been implicated in the aetiology of a number of important amyloid diseases, such as type 2 diabetes, Parkinson's…”
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Modulation of the Activity of the Insulin-Degrading Enzyme by Aβ Peptides by Kemeh, Merc M., Lazo, Noel D.

“…The insulin-degrading enzyme (IDE) is an evolutionarily conserved protease implicated in the degradation of insulin and amyloidogenic peptides. Most of the…”
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Binding Modes of Thioflavin T on the Surface of Amyloid Fibrils Studied by NMR by Ivancic, Valerie A., Ekanayake, Oshini, Lazo, Noel D.

“…The mechanism for the interaction of thioflavin T (ThT) with amyloid fibrils at the molecular level is not known. Here, we used 1H NMR spectroscopy to…”
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Curcumin modulates the self-assembly of the islet amyloid polypeptide by disassembling α-helix by Sparks, Samuel, Liu, Gai, Robbins, Kevin J., Lazo, Noel D.

“…► Curcumin delays the self-assembly of IAPP to NMR-invisible assemblies. ► Curcumin disassembles α-helix in maturing assemblies of IAPP. ► Curcumin modulates…”
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Binding Modes of ThioflavinT on the Surface of Amyloid Fibrils Studied by NMR by Ivancic, Valerie A, Ekanayake, Oshini, Lazo, Noel D

“…The mechanism for the interaction of thioflavin T (ThT) with amyloid fibrils at the molecular level is not known. Here, we used 1HNMR spectroscopy to determine…”
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Conformational Analysis of Thioflavin T Bound to the Surface of Amyloid Fibrils by Robbins, Kevin J, Liu, Gai, Selmani, Veli, Lazo, Noel D

“…The interaction of small molecules with the surface of amyloid assemblies is important for the detection and inhibition of amyloid formation. Thioflavin T…”
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Mechanistic Studies of Peptide Self-Assembly: Transient α-Helices to Stable β-Sheets by Liu, Gai, Prabhakar, Anabathula, Aucoin, Darryl, Simon, Miranda, Sparks, Samuel, Robbins, Kevin J, Sheen, Andrew, Petty, Sarah A, Lazo, Noel D

“…The pathologic self-assembly of proteins is associated with typically late-onset disorders such as Alzheimer’s disease, Parkinson’s disease, and type 2…”
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On the nucleation of amyloid β‐protein monomer folding by Lazo, Noel D., Grant, Marianne A., Condron, Margaret C., Rigby, Alan C., Teplow, David B.

“…Neurotoxic assemblies of the amyloid β‐protein (Aβ) have been linked strongly to the pathogenesis of Alzheimer's disease (AD). Here, we sought to monitor the…”
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Elucidating Amyloid β-Protein Folding and Assembly:  A Multidisciplinary Approach by Teplow, David B, Lazo, Noel D, Bitan, Gal, Bernstein, Summer, Wyttenbach, Thomas, Bowers, Michael T, Baumketner, Andrij, Shea, Joan-Emma, Urbanc, Brigita, Cruz, Luis, Borreguero, Jose, Stanley, H. Eugene

“…Oligomeric, neurotoxic amyloid protein assemblies are thought to be causative agents in Alzheimer's and other neurodegenerative diseases. Development of…”
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