Search Results - "Lazo, J S"

Discovery and Biological Evaluation of a New Family of Potent Inhibitors of the Dual Specificity Protein Phosphatase Cdc25 by Lazo, John S, Aslan, Diana C, Southwick, Eileen C, Cooley, Kathleen A, Ducruet, Alexander P, Joo, Beomjun, Vogt, Andreas, Wipf, Peter

“…The Cdc25 dual specificity phosphatases have central roles in coordinating cellular signaling processes and cell proliferation, but potent and selective…”
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Apolipoprotein A-I Directly Interacts with Amyloid Precursor Protein and Inhibits Aβ Aggregation and Toxicity by Koldamova, Radosveta P, Lefterov, Iliya M, Lefterova, Martina I, Lazo, John S

“…Amyloid precursor protein (APP) is the source of the neurotoxic amyloid β (Aβ) peptide associated with Alzheimer's disease. Apolipoprotein A-I (apoA-I), a…”
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Astrogliosis and behavioral changes in mice lacking the neutral cysteine protease bleomycin hydrolase by Montoya, S.E, Thiels, E, Card, J.P, Lazo, J.S

“…Abstract Bleomycin hydrolase (BLMH) is a multifaceted neutral cysteine protease with a suggested role in antigen presentation, homocysteine-thiolactone…”
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Metastasis-associated phosphatase PRL-2 regulates tumor cell migration and invasion by Wang, Y, Lazo, J S

“…The phosphatase of regenerating liver (PRL) family, comprising PRL-1, PRL-2 and PRL-3, is a group of prenylated phosphatases that are candidate cancer…”
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Cdc25 inhibition and cell cycle arrest by a synthetic thioalkyl vitamin K analogue by TAMURA, K, SOUTHWICK, E. C, KERNS, J, ROSI, K, CARR, B. I, WILCOX, C, LAZO, J. S

“…A synthetic vitamin K analogue, 2-(2-mercaptoethanol)-3-methyl-1,4-naphthoquinone or compound 5 (Cpd 5), was found previously to be a potent inhibitor of tumor…”
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Bcl-2 inhibits selective oxidation and externalization of phosphatidylserine during paraquat-induced apoptosis by Fabisiak, J.P. (University of Pittsburgh, Pittsburgh, PA.), Kagan, V.E, Ritov, V.B, Johnson, D.E, Lazo, J.S

“…Oxidative stress is a potential component of the final common pathway leading to apoptosis following many diverse stimuli. Here, we document that the oxidant…”
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Cytoplasmic metallothionein overexpression protects NIH 3T3 cells from tert-butyl hydroperoxide toxicity by SCHWARZ, M. A, LAZO, J. S, YALOWICH, J. C, REYNOLDS, I, KAGAN, V. E, TYURIN, V, YOUNG-MYEONG KIM, WATKINS, S. C, PITT, B. R

“…Metallothioneins (MT) are ubiquitous low molecular weight metal-binding proteins that may act as antioxidants. We examined the sensitivity of NIH 3T3 cells…”
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Metallothionein Protects Against the Cytotoxic and DNA-Damaging Effects of Nitric Oxide by Schwarz, Margaret A., Lazo, John S., Yalowich, Jack C., Allen, William P., Whitmore, Mark, Bergonia, Hector A., Tzeng, Edito, Billiar, Timothy R., Robbins, Paul D., Lancaster, Jack R., Pitt, Bruce R.

“…In inflammatory states, nitric oxide (·NO) may be synthesized from precursor L-arginine via inducible ·NO synthase (iNOS) in large amounts for prolonged…”
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Alterations in pulmonary mRNA encoding procollagens, fibronectin and transforming growth factor-beta precede bleomycin-induced pulmonary fibrosis in mice by Hoyt, D G, Lazo, J S

“…Female C57Bl/6 mice treated by constant s.c. infusion for 1 week with 100 mg of bleomycin per kg of body weight develop a more pronounced pulmonary fibrosis…”
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Collagen is a survival factor against LPS-induced apoptosis in cultured sheep pulmonary artery endothelial cells by Hoyt, D G, Mannix, R J, Rusnak, J M, Pitt, B R, Lazo, J S

“…Lipopolysaccharide (LPS) causes direct pulmonary endothelial injury that can precipitate cell death. We investigated the ability of LPS to produce apoptosis in…”
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Metallothioneins and cell death by anticancer drugs by Lazo, J S, Pitt, B R

“…Both pharmacologic and genetic methods are now available to manipulate intracellular levels of the protein thiol metallothionein. These approaches have begun…”
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Low molecular weight inhibitors of Myc-Max interaction and function by XIAOYING YIN, GIAP, Christine, LAZO, John S, PROCHOWNIK, Edward V

“…c-Myc is helix-loop-helix-leucine zipper (HLH-ZIP) oncoprotein that is frequently deregulated in human cancers. In order to bind DNA, regulate target gene…”
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Blocking of glioma proliferation in vitro and in vivo and potentiating the effects of BCNU and cisplatin : UCN-01, a selective protein kinase C inhibitor by POLLACK, I. F, KAWECKI, S, LAZO, J. S

“…Seven-hydroxystaurosporine (UCN-01) is a derivative of the nonselective protein kinase inhibitor staurosporine that exhibits significant selectivity for…”
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Integrins inhibit LPS-induced DNA strand breakage in cultured lung endothelial cells by Hoyt, D G, Mannix, R J, Gerritsen, M E, Watkins, S C, Lazo, J S, Pitt, B R

“…Collagen inhibits acute DNA strand breakage and apoptosis in sheep pulmonary artery endothelial cells (SPAEC) treated with lipopolysaccharide (LPS). Here we…”
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Overexpression of Metallothionein Confers Resistance to Anticancer Drugs by Kelley, Susan L., Basu, Alakananda, Teicher, Beverly A., Hacker, Miles P., Hamer, Dean H., Lazo, John S.

“…Resistance to antineoplastic agents is the major obstacle to curative therapy of cancer. Tumor cell lines with acquired resistance to the antineoplastic agent…”
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The Liver X Receptor Ligand T0901317 Decreases Amyloid β Production in Vitro and in a Mouse Model of Alzheimer's Disease by Koldamova, Radosveta P., Lefterov, Iliya M., Staufenbiel, Matthias, Wolfe, Darren, Huang, Shaohua, Glorioso, Joseph C., Walter, Michael, Roth, Michael G., Lazo, John S.

“…Recent studies indicate that oxysterols, which are ligands for the nuclear hormone liver X receptors (LXR), decrease amyloid β (Aβ) secretion in vitro. The…”
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Metallothionein null cells have increased sensitivity to anticancer drugs by KONDO, Y, WOO, E. S, MICHALSKA, A. E, CHOO, K. H. A, LAZO, J. S

“…Overexpression of metallothioneins (MTs) protects some cells against heavy metals, mutagens, anticancer agents, and reactive oxygen species. We have examined…”
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Human bleomycin hydrolase regulates the secretion of amyloid precursor protein by Lefterov, Iliya M., Koldamova, Radosveta P., Lazo, John S.

“…Human bleomycin hydrolase (hBH) is a neutral cysteine protease genetically associated with increased risk for Alzheimer disease. We show here that ectopic…”
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Nucleocytoplasmic functionality of metallothionein by WOO, E. S, LAZO, J. S

“…Appropriate nucleocytoplasmic partitioning of proteins can direct diverse cellular processes. Metallothioneins (MTs) are thiol-rich, stress-inducible proteins…”
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High dose continuous infusion of bleomycin in mice: a new model for drug-induced pulmonary fibrosis by Harrison, Jr, J H, Lazo, J S

“…Bleomycin (BLM) produces pulmonary fibrosis in mice when given as a single intratracheal injection, a single i.v. injection or multiple s.c. injections. All of…”
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