Search Results - "Lazo, D."

Inhibition of the Self-Assembly of Aβ and of Tau by Polyphenols: Mechanistic Studies by Zheng, Qiuchen, Kebede, Micheal T, Kemeh, Merc M, Islam, Saadman, Lee, Bethany, Bleck, Stuart D, Wurfl, Liliana A, Lazo, Noel D

“…The amyloid-β (Aβ) peptide and tau protein are thought to play key neuropathogenic roles in Alzheimer's disease (AD). Both Aβ and tau self-assemble to form the…”
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Highly toxic Aβ begets more Aβ by Kemeh, Merc M, Lazo, Noel D

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Hypovitaminosis D in patients with oral squamous cell carcinoma: Is a risk factor of developing this neoplasia? by Maturana-Ramiìrez, A., Aitken-Saavedra, J., Rojas-Zúñiga, G., Rojas-Alcayaga, G., Espinoza-Santander, I., Rebolledo, A., Fuentes, R., Reyes-Rojas, M., Araya, C., Lazo, D., Caamaño, D.

“…Hypovitaminosis D raised a significant public health concern due to its potential association with various diseases, including Oral Squamous Cell Carcinoma…”
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Familial Alzheimer's disease mutations alter the stability of the amyloid β-protein monomer folding nucleus by Grant, Marianne A, Lazo, Noel D, Lomakin, Aleksey, Condron, Margaret M, Arai, Hiromi, Yamin, Ghiam, Rigby, Alan C, Teplow, David B

“…Amyloid β-protein (Aβ) oligomers may be the proximate neurotoxins in Alzheimer's disease (AD). Recently, to elucidate the oligomerization pathway, we studied…”
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Solvent and Mutation Effects on the Nucleation of Amyloid β-Protein Folding by Cruz, Luis, Urbanc, Brigita, Borreguero, Jose M., Lazo, Noel D., Teplow, David B., Stanley, H. Eugene

“…Experimental evidence suggests that the folding and aggregation of the amyloid $\beta-protein$ (Aβ) into oligomers is a key pathogenetic event in Alzheimer's…”
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Effects of Familial Alzheimer’s Disease Mutations on the Folding Nucleation of the Amyloid β-Protein by Krone, Mary Griffin, Baumketner, Andrij, Bernstein, Summer L., Wyttenbach, Thomas, Lazo, Noel D., Teplow, David B., Bowers, Michael T., Shea, Joan-Emma

“…The effect of single amino acid substitutions associated with the Italian (E22K), Arctic (E22G), Dutch (E22Q) and Iowa (D23N) familial forms of Alzheimer's…”
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K114 (trans, trans)‐bromo‐2,5‐bis(4‐hydroxystyryl)benzene is an efficient detector of cationic amyloid fibrils by Selmani, Veli, Robbins, Kevin J., Ivancic, Valerie A., Lazo, Noel D.

“…Cationic amyloid fibrils found in human semen enhance the transmission of the human immunodeficiency virus (HIV) and thus, are named semen‐derived enhancer of…”
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Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme by Ivancic, Valerie A, Krasinski, Claire A, Zheng, Qiuchen, Meservier, Rebecca J, Spratt, Donald E, Lazo, Noel D

“…Insulin-degrading enzyme (IDE) is a zinc metalloprotease that selectively degrades biologically important substrates associated with type 2 diabetes and…”
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Folding Events in the 21-30 Region of Amyloid β-Protein (Aβ) Studied in silico by Borreguero, Jose M., Urbanc, Brigita, Lazo, Noel D., Buldyrev, Sergey V., Teplow, David B., Stanley, H. Eugene

“…Oligomeric assemblies of the amyloid β-protein (Aβ) have been implicated in the pathogenesis of Alzheimer's disease as a primary source of neurotoxicity…”
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Resveratrol Sustains Insulin-Degrading Enzyme Activity toward Aβ42 by Krasinski, Claire A, Ivancic, Valerie A, Zheng, Qiuchen, Spratt, Donald E, Lazo, Noel D

“…Alzheimer’s disease (AD), the most common cause of dementia in the elderly, is the sixth leading cause of death in the United States. We hypothesize that the…”
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On the nucleation of amyloid β‐protein monomer folding by Lazo, Noel D., Grant, Marianne A., Condron, Margaret C., Rigby, Alan C., Teplow, David B.

“…Neurotoxic assemblies of the amyloid β‐protein (Aβ) have been linked strongly to the pathogenesis of Alzheimer's disease (AD). Here, we sought to monitor the…”
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Mechanistic Studies of the Inhibition of Insulin Fibril Formation by Rosmarinic Acid by Zheng, Qiuchen, Lazo, Noel D

“…The self-assembly of insulin to form amyloid fibrils has been widely studied because it is a significant problem in the medical management of diabetes and is…”
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Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-Degrading Enzyme by Zheng, Qiuchen, Kebede, Micheal T, Lee, Bethany, Krasinski, Claire A, Islam, Saadman, Wurfl, Liliana A, Kemeh, Merc M, Ivancic, Valerie A, Jakobsche, Charles E, Spratt, Donald E, Lazo, Noel D

“…The insulin-degrading enzyme (IDE) possesses a strong ability to degrade insulin and Aβ42 that has been linked to the neurodegeneration in Alzheimer's disease…”
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Orbital reconstruction by Pedemonte, C, Lazo, D, Gonzalez, E, Vargas, I

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Short Amyloid-β (Aβ) Immunogens Reduce Cerebral Aβ Load and Learning Deficits in an Alzheimer's Disease Mouse Model in the Absence of an Aβ-Specific Cellular Immune Response by Maier, Marcel, Seabrook, Timothy J., Lazo, Noel D., Jiang, Liying, Das, Pritam, Janus, Christopher, Lemere, Cynthia A.

“…Amyloid-β (Aβ) immunotherapy lowers cerebral Aβ and improves cognition in mouse models of Alzheimer's disease (AD). A clinical trial using active immunization…”
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Objective and subjective assessment in closed reduction of zygomatic arch fractures by Lazo, D, Pedemonte, C, Gonzalez, E, Vargas, I, Pérez, H

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Late orbital post traumatic reconstruction by Lazo, D, Vargas, I, Gonzalez, E, Pedemonte, C, Pérez, H

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Bivalve taphonomy; testing the effect of life habits on the shell condition of the littleneck clam Protothaca (Protothaca) staminea (Mollusca, Bivalvia) by Lazo, Dario Gustavo

“…The littleneck clam Protothaca staminea in Argyle Creek and Argyle Lagoon on San Juan Island (Washington, USA) provides an ideal opportunity to test the effect…”
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Helix Dipole and Membrane Electrostatics Delineate Conformational Transitions in the Self-Assembly of Amyloidogenic Peptides by Zheng, Qiuchen, Carty, Senegal N, Lazo, Noel D

“…The self-assembly of amyloidogenic peptides on membrane surfaces is associated with the death of neurons and β-cells in Alzheimer’s disease and type 2…”
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Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease by Bowers, Michael T, Bernstein, Summer L, Dupuis, Nicholas F, Lazo, Noel D, Wyttenbach, Thomas, Condron, Margaret M, Bitan, Gal, Teplow, David B, Shea, Joan-Emma, Ruotolo, Brandon T, Robinson, Carol V

“…In recent years, small protein oligomers have been implicated in the aetiology of a number of important amyloid diseases, such as type 2 diabetes, Parkinson's…”
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