Search Results - "Lazenby, Audrey"

Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis by Roe, Jae-Seok, Hwang, Chang-Il, Somerville, Tim D.D., Milazzo, Joseph P., Lee, Eun Jung, Da Silva, Brandon, Maiorino, Laura, Tiriac, Hervé, Young, C. Megan, Miyabayashi, Koji, Filippini, Dea, Creighton, Brianna, Burkhart, Richard A., Buscaglia, Jonathan M., Kim, Edward J., Grem, Jean L., Lazenby, Audrey J., Grunkemeyer, James A., Hollingsworth, Michael A., Grandgenett, Paul M., Egeblad, Mikala, Park, Youngkyu, Tuveson, David A., Vakoc, Christopher R.

“…Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human malignancies, owing in part to its propensity for metastasis. Here, we used an organoid…”
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De Novo Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer by Tadros, Saber, Shukla, Surendra K, King, Ryan J, Gunda, Venugopal, Vernucci, Enza, Abrego, Jaime, Chaika, Nina V, Yu, Fang, Lazenby, Audrey J, Berim, Lyudmyla, Grem, Jean, Sasson, Aaron R, Singh, Pankaj K

“…Pancreatic adenocarcinoma is moderately responsive to gemcitabine-based chemotherapy, the most widely used single-agent therapy for pancreatic cancer. Although…”
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Myeloid-derived cullin 3 promotes STAT3 phosphorylation by inhibiting OGT expression and protects against intestinal inflammation by Li, Xinghui, Zhang, Zhibin, Li, Lupeng, Gong, Wei, Lazenby, Audrey J, Swanson, Benjamin J, Herring, Laura E, Asara, John M, Singer, Jeffrey D, Wen, Haitao

“…Signal transducer and activator of transcription 3 (STAT3) is a key mediator of intestinal inflammation and tumorigenesis. However, the molecular mechanism…”
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Differential expression of metabolic genes in tumor and stromal components of primary and metastatic loci in pancreatic adenocarcinoma by Chaika, Nina V, Yu, Fang, Purohit, Vinee, Mehla, Kamiya, Lazenby, Audrey J, DiMaio, Dominick, Anderson, Judy M, Yeh, Jen Jen, Johnson, Keith R, Hollingsworth, Michael A, Singh, Pankaj K

“…Pancreatic cancer is the fourth leading cause of cancer related deaths in the United States with a five-year survival rate of 6%. It is characterized by…”
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CD73 induces GM-CSF/MDSC-mediated suppression of T cells to accelerate pancreatic cancer pathogenesis by King, Ryan J., Shukla, Surendra K., He, Chunbo, Vernucci, Enza, Thakur, Ravi, Attri, Kuldeep S., Dasgupta, Aneesha, Chaika, Nina V., Mulder, Scott E., Abrego, Jaime, Murthy, Divya, Gunda, Venugopal, Pacheco, Camila G., Grandgenett, Paul M., Lazenby, Audrey J., Hollingsworth, Michael A., Yu, Fang, Mehla, Kamiya, Singh, Pankaj K.

“…Metabolic alterations regulate cancer aggressiveness and immune responses. Given the poor response of pancreatic ductal adenocarcinoma (PDAC) to conventional…”
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Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression by Hu, Tuo, Shukla, Surendra K., Vernucci, Enza, He, Chunbo, Wang, Dezhen, King, Ryan J., Jha, Kanupriya, Siddhanta, Kasturi, Mullen, Nicholas J., Attri, Kuldeep S., Murthy, Divya, Chaika, Nina V., Thakur, Ravi, Mulder, Scott E., Pacheco, Camila G., Fu, Xiao, High, Robin R., Yu, Fang, Lazenby, Audrey, Steegborn, Clemens, Lan, Ping, Mehla, Kamiya, Rotili, Dante, Chaudhary, Sarika, Valente, Sergio, Tafani, Marco, Mai, Antonello, Auwerx, Johan, Verdin, Eric, Tuveson, David, Singh, Pankaj K.

“…SIRT5 plays pleiotropic roles via post-translational modifications, serving as a tumor suppressor, or an oncogene, in different tumors. However, the role SIRT5…”
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Gastric adenocarcinoma with chief cell differentiation: a proposal for reclassification as oxyntic gland polyp/adenoma by Singhi, Aatur D, Lazenby, Audrey J, Montgomery, Elizabeth A

“…Gastric adenocarcinoma with chief cell differentiation (GA-CCD) has been reported as a new, rare variant of gastric adenocarcinoma. Only 12 cases in Japanese…”
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Up-regulation of N-cadherin by Collagen I-activated Discoidin Domain Receptor 1 in Pancreatic Cancer Requires the Adaptor Molecule Shc1 by Huang, Huocong, Svoboda, Robert A., Lazenby, Audrey J., Saowapa, Jintana, Chaika, Nina, Ding, Ke, Wheelock, Margaret J., Johnson, Keith R.

“…Pancreatic ductal adenocarcinomas are highly malignant cancers characterized by extensive invasion into surrounding tissues, metastasis to distant organs, and…”
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Aberrant Expression of Mucin Core Proteins and O-Linked Glycans Associated with Progression of Pancreatic Cancer by REMMERS, Neeley, ANDERSON, Judy M, LINDE, Erin M, DIMAIO, Dominick J, LAZENBY, Audrey J, WANDALL, Hans H, MANDEL, Ulla, CLAUSEN, Henrik, FANG YU, HOLLINGSWORTH, Michael A

“…Mucin expression is a common feature of most adenocarcinomas and features prominently in current attempts to improve diagnosis and therapy for pancreatic…”
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Stathmin expression in metastatic colorectal cancer by Leiphrakpam, Premila D., Lazenby, Audrey J., Smith, Lynette M., Brattain, Michael G., Are, Chandrakanth

“…Objectives To evaluate the relationship between stathmin expression and clinical outcome in colorectal cancer (CRC). Background Stathmin is a phosphoprotein…”
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Porcine pancreatic ductal epithelial cells transformed with KRASG12D and SV40T are tumorigenic by Bailey, Katie L., Cartwright, Sara B., Patel, Neesha S., Remmers, Neeley, Lazenby, Audrey J., Hollingsworth, Michael A., Carlson, Mark A.

“…We describe our initial studies in the development of an orthotopic, genetically defined, large animal model of pancreatic cancer. Primary pancreatic…”
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Induction of pancreatic neoplasia in the KRAS/TP53 Oncopig by Mondal, Pinaki, Patel, Neesha S, Bailey, Katie, Aravind, Shruthishree, Cartwright, Sara B, Hollingsworth, Michael A, Lazenby, Audrey J, Carlson, Mark A

“…The 5-year survival of pancreatic cancer (PC) remains low. Murine models may not adequately mimic human PC and can be too small for medical device development…”
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Concordance between whole-slide imaging and light microscopy for routine surgical pathology by Campbell, W. Scott, MBA, Lele, Subodh M., MD, West, William W., MD, Lazenby, Audrey J., MD, Smith, Lynette M., MS, Hinrichs, Steven H., MD

“…Summary The use of high-resolution digital images of histopathology slides as a routine diagnostic tool for surgical pathology was investigated. The study…”
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Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2–SP1–SAT1 axis by Murthy, Divya, Attri, Kuldeep S., Shukla, Surendra K., Thakur, Ravi, Chaika, Nina V., He, Chunbo, Wang, Dezhen, Jha, Kanupriya, Dasgupta, Aneesha, King, Ryan J., Mulder, Scott E., Souchek, Joshua, Gebregiworgis, Teklab, Rai, Vikant, Patel, Rohit, Hu, Tuo, Rana, Sandeep, Kollala, Sai Sundeep, Pacheco, Camila, Grandgenett, Paul M., Yu, Fang, Kumar, Vikas, Lazenby, Audrey J., Black, Adrian R., Ulhannan, Susanna, Jain, Ajay, Edil, Barish H., Klinkebiel, David L., Powers, Robert, Natarajan, Amarnath, Hollingsworth, Michael A., Mehla, Kamiya, Ly, Quan, Chaudhary, Sarika, Hwang, Rosa F., Wellen, Kathryn E., Singh, Pankaj K.

“…The ability of tumour cells to thrive in harsh microenvironments depends on the utilization of nutrients available in the milieu. Here we show that pancreatic…”
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Prognostic and therapeutic implications of NHERF1 expression and regulation in colorectal cancer by Leiphrakpam, Premila D., Lazenby, Audrey J., Chowdhury, Sanjib, Smith, Lynette M., Mathiesen, Michelle, Brattain, Michael G., Wang, Jing, Black, Jennifer D., Are, Chandrakanth

“…Background Na+/H+ exchanger regulatory factor 1 (NHERF1) has been implicated in the tumorigenesis of several cancer types and is a potential therapeutic…”
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Correlation of PRL3 expression with colorectal cancer progression by Leiphrakpam, Premila D., Lazenby, Audrey J., Smith, Lynette M., Brattain, Michael G., Black, Jennifer D., Wang, Jing, Are, Chandrakanth

“…Objectives To evaluate the relationship between phosphatase of regenerating liver 3 (PRL3) expression and clinical outcome in colorectal cancer (CRC)…”
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Whole slide imaging diagnostic concordance with light microscopy for breast needle biopsies by Campbell, W. Scott, PhD, MBA, Hinrichs, Steven H., MD, Lele, Subodh M., MD, Baker, John J., MD, Lazenby, Audrey J., MD, Talmon, Geoffrey A., MD, Smith, Lynette M., MS, West, William W., MD

“…Summary This study investigated the diagnostic accuracy of whole slide imaging (WSI) in breast needle biopsy diagnosis in comparison with standard light…”
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A computable pathology report for precision medicine: extending an observables ontology unifying SNOMED CT and LOINC by Campbell, Walter S, Karlsson, Daniel, Vreeman, Daniel J, Lazenby, Audrey J, Talmon, Geoffrey A, Campbell, James R

“…Abstract Background The College of American Pathologists (CAP) introduced the first cancer synoptic reporting protocols in 1998. However, the objective of a…”
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Author Correction: Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2–SP1–SAT1 axis by Murthy, Divya, Attri, Kuldeep S., Shukla, Surendra K., Thakur, Ravi, Chaika, Nina V., He, Chunbo, Wang, Dezhen, Jha, Kanupriya, Dasgupta, Aneesha, King, Ryan J., Mulder, Scott E., Souchek, Joshua, Gebregiworgis, Teklab, Rai, Vikant, Patel, Rohit, Hu, Tuo, Rana, Sandeep, Kollala, Sai Sundeep, Pacheco, Camila, Grandgenett, Paul M., Yu, Fang, Kumar, Vikas, Lazenby, Audrey J., Black, Adrian R., Ulhannan, Susanna, Jain, Ajay, Edil, Barish H., Klinkebiel, David L., Powers, Robert, Natarajan, Amarnath, Hollingsworth, Michael A., Mehla, Kamiya, Ly, Quan, Chaudhary, Sarika, Hwang, Rosa F., Wellen, Kathryn E., Singh, Pankaj K.

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Phase I trial of concurrent stereotactic body radiotherapy and nelfinavir for locally advanced borderline or unresectable pancreatic adenocarcinoma by Lin, Chi, Verma, Vivek, Ly, Quan P., Lazenby, Audrey, Sasson, Aaron, Schwarz, James K., Meza, Jane L., Are, Chandrakanth, Li, Sicong, Wang, Shuo, Hahn, Stephen M., Grem, Jean L.

“…•No studies have assessed SBRT + NFV for borderline/unresectable pancreatic cancer.•This phase I trial enrolled 46 patients, of which 39 received per-protocol…”
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