Search Results - "Lazartigues, Eric"

Expression of ACE2 in Human Neurons Supports the Neuro-Invasive Potential of COVID-19 Virus by Xu, Jiaxi, Lazartigues, Eric

“…The recent outbreak of 2019 coronavirus disease (COVID-19), caused by a novel coronavirus, has now spread quickly worldwide. Like the severe acute respiratory…”
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Endocrine Significance of SARS-CoV-2’s Reliance on ACE2 by Lazartigues, Eric, Qadir, Mirza Muhammad Fahd, Mauvais-Jarvis, Franck

“…Abstract The current COVID-19 pandemic is the most disruptive event in the past 50 years, with a global impact on health care and world economies. It is caused…”
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Angiotensin-converting enzyme 2 in the brain: properties and future directions by Xia, Huijing, Lazartigues, Eric

“…Angiotensin (Ang)-converting enzyme (ACE) 2 cleaves Ang-II into the vasodilator peptide Ang-(1-7), thus acting as a pivotal element in balancing the local…”
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ACE2 mouse models: a toolbox for cardiovascular and pulmonary research by Jia, Hongpeng, Yue, Xinping, Lazartigues, Eric

“…Angiotensin-converting enzyme 2 (ACE2) has been identified as the host entry receptor for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…”
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Nicotine and the renin-angiotensin system by Oakes, Joshua M, Fuchs, Robert M, Gardner, Jason D, Lazartigues, Eric, Yue, Xinping

“…Cigarette smoking is the single most important risk factor for the development of cardiovascular and pulmonary diseases (CVPD). Although cigarette smoking has…”
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158-OR: Perinatal Hypercaloric Diet Leads to Cardiometabolic Imbalance via Hypothalamic Methylation Events in Male Mice by ELGAZZAZ, MONA, BERDASCO, CLARA, LAZARTIGUES, ERIC D.

“…Cardiometabolic diseases are among the highest prevalent diseases worldwide. We have reported that perinatal maternal programming through hypercaloric diet…”
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ACE2/ANG-(1-7)/Mas pathway in the brain: the axis of good by Xu, Ping, Sriramula, Srinivas, Lazartigues, Eric

“…The last decade has seen the discovery of several new components of the renin-angiotensin system (RAS). Among them, angiotensin converting enzyme-2 (ACE2) and…”
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ACE2 and ADAM17 Interaction Regulates the Activity of Presympathetic Neurons by Mukerjee, Snigdha, Gao, Hong, Xu, Jiaxi, Sato, Ryosuke, Zsombok, Andrea, Lazartigues, Eric

“…Brain renin angiotensin system within the paraventricular nucleus plays a critical role in balancing excitatory and inhibitory inputs to modulate sympathetic…”
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Clinical Relevance and Role of Neuronal AT1 Receptors in ADAM17-Mediated ACE2 Shedding in Neurogenic Hypertension by Xu, Jiaxi, Sriramula, Srinivas, Xia, Huijing, Moreno-Walton, Lisa, Culicchia, Frank, Domenig, Oliver, Poglitsch, Marko, Lazartigues, Eric

“…Rationale:Neurogenic hypertension is characterized by an increase in sympathetic activity and often resistance to drug treatments. We previously reported that…”
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Angiotensin II Mediates Angiotensin Converting Enzyme Type 2 Internalization and Degradation Through an Angiotensin II Type I Receptor–Dependent Mechanism by Deshotels, Matthew R, Xia, Huijing, Sriramula, Srinivas, Lazartigues, Eric, Filipeanu, Catalin M

“…Angiotensin-converting enzyme type 2 (ACE2) is a pivotal component of the renin–angiotensin system, promoting the conversion of angiotensin II (Ang-II) to…”
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Brain-targeted angiotensin-converting enzyme 2 overexpression attenuates neurogenic hypertension by inhibiting cyclooxygenase-mediated inflammation by Sriramula, Srinivas, Xia, Huijing, Xu, Ping, Lazartigues, Eric

“…Overactivity of the renin-angiotensin system, oxidative stress, and cyclooxygenases (COX) in the brain are implicated in the pathogenesis of hypertension. We…”
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A Dynamic Variation of Pulmonary ACE2 Is Required to Modulate Neutrophilic Inflammation in Response to Pseudomonas aeruginosa Lung Infection in Mice by Sodhi, Chhinder P, Nguyen, Jenny, Yamaguchi, Yukihiro, Werts, Adam D, Lu, Peng, Ladd, Mitchell R, Fulton, William B, Kovler, Mark L, Wang, Sanxia, Prindle, Jr, Thomas, Zhang, Yong, Lazartigues, Eric D, Holtzman, Michael J, Alcorn, John F, Hackam, David J, Jia, Hongpeng

“…Angiotensin-converting enzyme 2 (ACE2) is a potent negative regulator capable of restraining overactivation of the renin-angiotensin system, which contributes…”
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Brain Angiotensin-Converting Enzyme Type 2 Shedding Contributes to the Development of Neurogenic Hypertension by Xia, Huijing, Sriramula, Srinivas, Chhabra, Kavaljit H, Lazartigues, Eric

“…RATIONALE:Overactivity of the brain renin–angiotensin system is a major contributor to neurogenic hypertension. Although overexpression of…”
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1538-P: Brain TGFß Regulates Glucose Tolerance in Male Mice with Metabolic Syndrome by ELGAZZAZ, MONA, MIAO, KEVIN, NUZZO, ANNA R., RESTIVO, LUKE, MOLES, KARL, LAZARTIGUES, ERIC D.

“…Hypothalamic inflammation contributes to insulin resistance and obesity. Transforming growth factor beta (TGFβ) is among the inflammatory mediators inducing…”
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ADAM17-Mediated Shedding of Inflammatory Cytokines in Hypertension by de Queiroz, Thyago M, Lakkappa, Navya, Lazartigues, Eric

“…The increase of Angiontesin-II (Ang-II), one of the key peptides of the renin-angiotensin system (RAS), and its binding to the Ang-II type 1 receptor (AT R)…”
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172-OR: Perinatal Exposure to a Western Diet Alters Hypothalamic Gene Expression and Predisposes to Diabetes in Adult Male Mice by ELGAZZAZ, MONA, LAZARTIGUES, ERIC D., MAUVAIS-JARVIS, FRANCK

“…Cardiometabolic diseases are among the most prevalent diseases worldwide. Maternal epigenetic imprinting affects gene expression in offspring, leading to…”
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ACE2 overexpression in the paraventricular nucleus attenuates angiotensin II-induced hypertension by Sriramula, Srinivas, Cardinale, Jeffrey P., Lazartigues, Eric, Francis, Joseph

“…Aims Angiotensin II (Ang II) has been shown to have both central and peripheral effects in mediating hypertension, for which the hypothalamic paraventricular…”
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1272-P: Genomic Rearrangement in Noncoding Region of Chromosome 1 Leads to Spontaneous Obesity and Type 2 Diabetes by WHITE, DONNELL, WU, JIAN, LAUTERBOECK, LOTHAR, KANG, SUNG WOOK, ELGAZZAZ, MONA, ALAHARI, SURESH, LAZARTIGUES, ERIC D., YANG, QINGLIN

“…Obesity is a major health risk for type 2 diabetes, along with many other disease conditions. We discovered spontaneous obese mice among a conditional…”
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Effects of Chronic Nicotine Inhalation on Systemic and Pulmonary Blood Pressure and Right Ventricular Remodeling in Mice by Oakes, Joshua M., Xu, Jiaxi, Morris, Tamara M., Fried, Nicholas D., Pearson, Charlotte S., Lobell, Thomas D., Gilpin, Nicholas W., Lazartigues, Eric, Gardner, Jason D., Yue, Xinping

“…Cigarette smoking is the single most important risk factor for the development of cardiovascular and pulmonary diseases; however, the role of nicotine in the…”
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1684-P: Transgene Integration-Induced Genomic Rearrangement in a Noncoding Region of Chromosome 1 Leads to Spontaneous Obesity and Type 2 Diabetes in Mice by WHITE, DONNELL, WU, JIAN, KANG, SUNGWOOK, LAUTERBOECK, LOTHAR, MOBASHERAN, PARNIA, PALIARIN, FRANCIELY, NGUYEN, TINA, ELGAZZAZ, MONA, MAIYA, RAJANI, ALAHARI, SURESH, LAZARTIGUES, ERIC D., YANG, QINGLIN

“…Obesity is a critical risk factor for type 2 diabetes (T2D) and has become a global health issue. We found that a mouse line (C57/B6J) of Floxed-stop over…”
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