Search Results - "Lazarow, Paul"

The import receptor Pex7p and the PTS2 targeting sequence by Lazarow, Paul B

“…This chapter concerns one branch of the peroxisome import pathway for newly-synthesized peroxisomal proteins, specifically the branch for matrix proteins that…”
Get more information

The intracellular bacteria Chlamydia hijack peroxisomes and utilize their enzymatic capacity to produce bacteria-specific phospholipids by Boncompain, Gaelle, Müller, Constanze, Meas-Yedid, Vannary, Schmitt-Kopplin, Philippe, Lazarow, Paul B, Subtil, Agathe

“…Chlamydia trachomatis is an obligate intracellular pathogen responsible for loss of eyesight through trachoma and for millions of cases annually of sexually…”
Get full text

Viruses exploiting peroxisomes by Lazarow, Paul B

“…Highlights ► Peroxisomes catalyze diverse metabolic reactions, many of which involve lipids. ► Medically important viruses exploit peroxisomes in ways that are…”
Get full text

Chapter 3.1.7. The import receptor Pex7p and the PTS2 targeting sequence by Lazarow, Paul B.

“…This chapter concerns one branch of the peroxisome import pathway for newly-synthesized peroxisomal proteins, specifically the branch for matrix proteins that…”
Get full text

Clathrin-independent endocytosis used by the IL-2 receptor is regulated by Rac1, Pak1 and Pak2 by Grassart, Alexandre, Dujeancourt, Annick, Lazarow, Paul B, Dautry-Varsat, Alice, Sauvonnet, Nathalie

“…There are several endocytic pathways, which are either dependent on or independent of clathrin. This study focuses on a poorly characterized…”
Get full text

PEROXISOME BIOGENESIS by Purdue, P. Edward, Lazarow, Paul B

“…Fifteen years ago, we had a model of peroxisome biogenesis that involved growth and division of preexisting peroxisomes. Today, thanks to genetically tractable…”
Get full text

Pex7p Translocates in and out of Peroxisomes in Saccharomyces cerevisiae by Nair, Devi M., Purdue, P. Edward, Lazarow, Paul B.

“…Pex7p is the soluble receptor responsible for importing into peroxisomes newly synthesized proteins bearing a type 2 peroxisomal targeting sequence. We observe…”
Get full text

Rhizomelic chondrodysplasia punctata is caused by deficiency of human PEX7, a homologue of the yeast PTS2 receptor by Purdue, P. Edward, Zhang, Jing Wei, Skoneczny, Marek, Lazarow, Paul B

“…The rhizomelic form of chondrodysplasia punctata (RCDP) is an autosomal recessive disease of peroxisome biogenesis characterized by deficiencies in several…”
Get full text

Peroxisome biogenesis: advances and conundrums by Lazarow, Paul B

“…Investigations of peroxisome biogenesis in diverse organisms reveal new details of this unique process and its evolutionary conservation. Interactions among…”
Get full text

Pex18p and Pex21p, a novel pair of related peroxins essential for peroxisomal targeting by the PTS2 pathway by Purdue, P.E. (Mount Sinai School of Medicine, New York, NY.), Yang, X, Lazarow, P.B

“…We have identified ScPex18p and ScPex21p, two novel S. cerevisiae peroxins required for protein targeting via the PTS2 branch of peroxisomal biogenesis…”
Get full text

Targeting of Human Catalase to Peroxisomes Is Dependent upon a Novel COOH-Terminal Peroxisomal Targeting Sequence by Purdue, P. Edward, Lazarow, Paul B.

“…We have identified a novel peroxisomal targeting sequence (PTS) at the extreme COOH terminus of human catalase. The last four amino acids of this protein…”
Get full text

PEB1 (PAS7) in Saccharomyces cerevisiae Encodes a Hydrophilic, Intra-Peroxisomal Protein That Is a Member of the WD Repeat Family and Is Essential for the Import of Thiolase into Peroxisomes by Zhang, Jing Wei, Lazarow, Paul B.

“…We have previously described mutant S. cerevisiae that are defective in peroxisome biogenesis (peb mutants) (Zhang, J. W., Y. Han, and P. B. Lazarow. 1993. J…”
Get full text

Pex18p Is Constitutively Degraded during Peroxisome Biogenesis by Purdue, P. Edward, Lazarow, Paul B.

“…Pex18p and Pex21p are structurally related yeast peroxins (proteins required for peroxisome biogenesis) that are partially redundant in function. One or the…”
Get full text

Peb1p (Pas7p) Is an Intraperoxisomal Receptor for the NH2-Terminal, Type 2, Peroxisomal Targeting Sequence of Thiolase: Peb1p Itself Is Targeted to Peroxisomes by an NH2-Terminal Peptide by Zhang, Jing Wei, Lazarow, Paul B.

“…Peb1 is a peroxisome biogenesis mutant isolated in Saccharomyces cerevisiae that is selectively defective in the import of thiolase into peroxisomes but has a…”
Get full text

Peroxisome structure, function, and biogenesis--human patients and yeast mutants show strikingly similar defects in peroxisome biogenesis by Lazarow, P B

“…Peroxisomes are found in almost all eukaryotic cells. Two major functions of the organelle are in lipid metabolism: peroxisomes catalyze the initial steps in…”
Get more information

Isolation of a Chinese hamster fibroblast variant defective in dihydroxyacetonephosphate acyltransferase activity and plasmalogen biosynthesis: use of a novel two-step selection protocol by Nagan, N, Hajra, A K, Larkins, L K, Lazarow, P, Purdue, P E, Rizzo, W B, Zoeller, R A

“…We have developed a two-step selection protocol to generate a population of Chinese hamster ovary (CHO) cell variants that are plasmalogen-deficient, but…”
Get full text

A Fibroblast Cell Line Defective in Alkyl-Dihydroxyacetone Phosphate Synthase: A Novel Defect in Plasmalogen Biosynthesis by Nagan, Narasimhan, Hajra, Amiya K., Das, Arun K., Moser, Hugo W., Moser, Ann, Lazarow, Paul, Purdue, P. Edward, Zoeller, Raphael A.

“…Using fluorescence-activated cytotoxicity selection, followed by colony autoradiographic screening of the surviving population, we have isolated a unique…”
Get full text

Novel peroxisome clustering mutants and peroxisome biogenesis mutants of Saccharomyces cerevisiae by Zhang, J.W, Han, Y, Lazarow, P.B

“…The goal of this research is to identify and characterize the protein machinery that functions in the intracellular translocation and assembly of peroxisomal…”
Get full text

Peroxisomal Defects in Neonatal-Onset and X-Linked Adrenoleukodystrophies by Goldfischer, Sidney, Collins, Janna, Rapin, Isabelle, Coltoff-Schiller, Bernice, Chang, Chung-Ho, Nigro, Michael, Black, Virginia H., Javitt, Norman B., Moser, Hugo W., Lazarow, Paul B.

“…Accumulation of very long chain fatty acids in X-linked and neonatal forms of adrenoleukodystrophy (ALD) appears to be a consequence of deficient peroxisomal…”
Get full text

The Intracellular Bacteria Chlamydia Hijack Peroxisomes and Utilize Their Enzymatic Capacity to Produce Bacteria-Specific Phospholipids: e86196 by Boncompain, Gaelle, Mueller, Constanze, Meas-Yedid, Vannary, Schmitt-Kopplin, Philippe, Lazarow, Paul B, Subtil, Agathe

“…Chlamydia trachomatis is an obligate intracellular pathogen responsible for loss of eyesight through trachoma and for millions of cases annually of sexually…”
Get full text