Search Results - "Lazarow, P B"

PEROXISOME BIOGENESIS by Purdue, P. Edward, Lazarow, Paul B

“…Fifteen years ago, we had a model of peroxisome biogenesis that involved growth and division of preexisting peroxisomes. Today, thanks to genetically tractable…”
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Rhizomelic chondrodysplasia punctata is caused by deficiency of human PEX7, a homologue of the yeast PTS2 receptor by Purdue, P. Edward, Zhang, Jing Wei, Skoneczny, Marek, Lazarow, Paul B

“…The rhizomelic form of chondrodysplasia punctata (RCDP) is an autosomal recessive disease of peroxisome biogenesis characterized by deficiencies in several…”
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Targeting of Human Catalase to Peroxisomes Is Dependent upon a Novel COOH-Terminal Peroxisomal Targeting Sequence by Purdue, P. Edward, Lazarow, Paul B.

“…We have identified a novel peroxisomal targeting sequence (PTS) at the extreme COOH terminus of human catalase. The last four amino acids of this protein…”
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Peroxisomal Membrane Ghosts in Zellweger Syndrome--Aberrant Organelle Assembly by Santos, M. J., Imanaka, T., Shio, H., Small, G. M., Lazarow, P. B.

“…Peroxisomes are apparently missing in Zellweger syndrome; nevertheless, some of the integral membrane proteins of the organelle are present. Their distribution…”
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Peroxisomal integral membrane proteins in control and Zellweger fibroblasts by Santos, M J, Imanaka, T, Shio, H, Lazarow, P B

“…An entire organelle, the peroxisome, appears to be missing in Zellweger syndrome, causing profound neurological problems and neonatal death. One hypothesis for…”
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Acyl‐CoA oxidase contains two targeting sequences each of which can mediate protein import into peroxisomes by Small, G. M., Szabo, L. J., Lazarow, P. B.

“…Acyl‐CoA oxidase is a major induced enzyme in peroxisomes of Candida tropicalis grown on fatty acids. The gene, POX4, encoding acyl‐CoA oxidase was expressed…”
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Peroxisome structure, function, and biogenesis--human patients and yeast mutants show strikingly similar defects in peroxisome biogenesis by Lazarow, P B

“…Peroxisomes are found in almost all eukaryotic cells. Two major functions of the organelle are in lipid metabolism: peroxisomes catalyze the initial steps in…”
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Rat liver peroxisomes catalyze the beta oxidation of fatty acids by Lazarow, P B

“…Peroxisomes were purified by differential and equilibrium density centrifugation from the livers of rats treated with clofibrate to enhance their peroxisomal…”
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Isolation of Intracellular Membranes by Means of Sodium Carbonate Treatment: Application to Endoplasmic Reticulum by Fujiki, Yukio, Hubbard, Ann L., Fowler, Stanley, Lazarow, Paul B.

“…A rapid and simple method for the isolation of membranes from subcellular organelles is described. The procedure consists of diluting the organelles in…”
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Synthesis of a Major Integral Membrane Polypeptide of Rat Liver Peroxisomes on Free Polysomes by Fujiki, Yukio, Rachubinski, Richard A., Lazarow, Paul B.

“…The manner of synthesis and assembly of the peroxisomal membrane proteins is unknown. Understanding these processes is essential to an understanding of the…”
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Rhizomelic chondrodysplasia punctata, a peroxisomal biogenesis disorder caused by defects in Pex7p, a peroxisomal protein import receptor : A minireview by PURDUE, P. E, SKONECZNY, M, XUDONG YANG, ZHANG, J.-W, LAZAROW, P. B

“…Rhizomelic chondrodysplasia punctata (RCDP) is a lethal autosomal recessive disease corresponding to complementation group 11 (CG11), the second most common of…”
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Peroxisomes in Saccharomyces cerevisiae: immunofluorescence analysis and import of catalase A into isolated peroxisomes by THIERINGER, R, SHIO, H, YINGSHI HAN, COHEN, G, LAZAROW, P. B

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Translocation of Acyl-CoA Oxidase into Peroxisomes Requires ATP Hydrolysis but Not a Membrane Potential by Imanaka, Tsuneo, Small, Gillian M., Lazarow, Paul B.

“…An efficient system for the import of newly synthesized proteins into highly purified rat liver peroxisomes was reconstituted in vitro. 35 S-Labeled acyl-CoA…”
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A Fatty Acyl-CoA Oxidizing System in Rat Liver Peroxisomes; Enhancement by Clofibrate, a Hypolipidemic Drug by Lazarow, Paul B., De Duve, Christian

“…Purified rat liver peroxisomes contain a cyanide-insensitive fatty acyl-CoA oxidizing system that uses O2and NAD as electron acceptors. The system was detected…”
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Chinese hamster ovary cell mutants defective in peroxisome biogenesis. Comparison to Zellweger syndrome by ZOELLER, R. A, ALLEN, L.-A. H, SANTOS, M. J, LAZAROW, P. B, HASHIMOTO, T, TARTAKOFF, A. M, RAETZ, C. R. H

“…We have previously reported the isolation of Chinese hamster ovary (CHO) cell mutants that are defective in the biosynthesis of plasmalogens, deficient in at…”
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Post-translational import of fatty acyl-CoA oxidase and catalase into peroxisomes of rat liver in vitro by Fujiki, Y, Lazarow, P B

“…Total polysomal RNA of rat liver was translated in vitro in a rabbit reticulocyte lysate system. The translation products were mixed with a postnuclear…”
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Peroxisome biogenesis: advances and conundrums by Lazarow, Paul B

“…Investigations of peroxisome biogenesis in diverse organisms reveal new details of this unique process and its evolutionary conservation. Interactions among…”
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Partial Disassembly of Peroxisomes by Stefan E. H. Alexson, Fujiki, Yukio, Shio, Helen, Lazarow, Paul B.

“…Rat liver peroxisomes were subjected to a variety of procedures intended to partially disassemble or damage them; the effects were analyzed by recentrifugation…”
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Novel peroxisome clustering mutants and peroxisome biogenesis mutants of Saccharomyces cerevisiae by Zhang, J.W, Han, Y, Lazarow, P.B

“…The goal of this research is to identify and characterize the protein machinery that functions in the intracellular translocation and assembly of peroxisomal…”
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The role of peroxisomes in mammalian cellular metabolism by Lazarow, P. B.

“…Peroxisomes, which are widely distributed in mammalian tissues, carry out several important functions in cellular metabolism. Production of…”
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