Search Results - "Lazarova, Dessislava"

Tolerable treatment of glioblastoma with redox-cycling 'mitocans': a comparative study in vivo by Sumiyoshi, Akira, Shibata, Sayaka, Lazarova, Dessislava, Zhelev, Zhivko, Aoki, Ichio, Bakalova, Rumiana

“…The present study describes a pharmacological strategy for the treatment of glioblastoma by redoxcycling 'mitocans' such as quinone/ascorbate combination…”
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Quantum Sensors To Track Total Redox-Status and Oxidative Stress in Cells and Tissues Using Electron-Paramagnetic Resonance, Magnetic Resonance Imaging, and Optical Imaging by Lazarova, Dessislava, Semkova, Severina, Zlateva, Genoveva, Tatsuya, Higashi, Aoki, Ichio, Bakalova, Rumiana

“…Total redox capacity (TRC) and oxidative stress (OxiStress) of biological objects (such as cells, tissues, and body fluids) are some of the most frequently…”
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Redox-Cycling "Mitocans" as Effective New Developments in Anticancer Therapy by Bakalova, Rumiana, Lazarova, Dessislava, Sumiyoshi, Akira, Shibata, Sayaka, Zhelev, Zhivko, Nikolova, Biliana, Semkova, Severina, Vlaykova, Tatyana, Aoki, Ichio, Higashi, Tatsuya

“…Our study proposes a pharmacological strategy to target cancerous mitochondria via redox-cycling "mitocans" such as quinone/ascorbate (Q/A) redox-pairs, which…”
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Redox-related Molecular Mechanism of Sensitizing Colon Cancer Cells to Camptothecin Analog SN38 by Nikolova, Biliana, Semkova, Severina, Tsoneva, Iana, Stoyanova, Elena, Lefterov, Pavel, Lazarova, Dessislava, Zhelev, Zhivko, Aoki, Ichio, Higashi, Tatsuya, Bakalova, Rumiana

“…Background/Aim: The aim of this study was to elucidate the possibility of sensitizing colon cancer cells to the chemotherapeutic drug SN38 and investigate its…”
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Selective Targeting of Cancerous Mitochondria and Suppression of Tumor Growth Using Redox-Active Treatment Adjuvant by Higashi, Tatsuya, Aoki, Ichio, Shibata, Sayaka, Takeshima, Tsuguhide, Miller, Thomas, Zhelev, Zhivko, Ivanova, Donika, Semkova, Severina, Bakalova, Rumiana, Lazarova, Dessislava

“…Redox-active substances and their combinations, such as of quinone/ascorbate and in particular menadione/ascorbate (M/A; also named Apatone®), attract…”
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Imaging of Superoxide Generation in the Dopaminergic Area of the Brain in Parkinson’s Disease, Using Mito-TEMPO by Zhelev, Zhivko, Bakalova, Rumiana, Aoki, Ichio, Lazarova, Dessislava, Saga, Tsuneo

“…We report a new methodology for direct visualization of superoxide production in the dopaminergic area of the brain in Parkinson’s disease, based on the redox…”
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Imaging of redox-imbalance and oxidative stress in kidney in vivo, induced by dietary cholesterol by Lazarova, Dessislava, Shibata, Sayaka, Ishii, Itsuko, Zlateva, Genoveva, Zhelev, Zhivko, Aoki, Ichio, Bakalova, Rumiana

“…We used a mitochondria-penetrating nitroxide, mito-TEMPO, as a contrast probe for imaging of kidney dysfunction in mice, based on the redox-imbalance and…”
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A “Weird” Mitochondrial Fatty Acid Oxidation as a Metabolic “Secret” of Cancer by Zhelev, Zhivko, Aoki, Ichio, Lazarova, Dessislava, Vlaykova, Tatyana, Higashi, Tatsuya, Bakalova, Rumiana

“…Cancer metabolism is an extensively studied field since the discovery of the Warburg effect about 100 years ago and continues to be increasingly intriguing and…”
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Effect of Alpha-tocopheryl Succinate on the Cytotoxicity of Anticancer Drugs Towards Leukemia Lymphocytes by Ivanova, Donika, Zhelev, Zhivko, Zlateva, Genoveva, Lazarova, Dessislava, Yaneva, Zvezdelina, Panovska, Radmila, Aoki, Ichio, Bakalova, Rumiana

“…This study analysed the effect of α-tocopheryl succinate (α-TS) on the redox-state of leukemia and normal lymphocytes, as well as their sensitization to…”
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Vitamins C and K3: A Powerful Redox System for Sensitizing Leukemia Lymphocytes to Everolimus and Barasertib by Ivanova, Donika, Zhelev, Zhivko, Lazarova, Dessislava, Getsov, Plamen, Bakalova, Rumiana, Aoki, Ichio

“…Recent studies provided convincing evidence for the anticancer activity of combined application of vitamin C and pro-vitamin K3 (menadione). The molecular…”
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Pharmacological Strategy for Selective Targeting of Glioblastoma by Redox-active Combination Drug - Comparison With the Chemotherapeutic Standard-of-care Temozolomide by Sumiyoshi, Akira, Shibata, Sayaka, Zhelev, Zhivko, Miller, Thomas, Lazarova, Dessislava, Zlateva, Genoveva, Aoki, Ichio, Bakalova, Rumiana

“…We describe a pharmacological strategy for selectively targeting glioblastoma using a redox-active combination drug menadione/ascorbate (M/A), compared to the…”
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Over-Reduced State of Mitochondria as a Trigger of "β-Oxidation Shuttle" in Cancer Cells by Zhelev, Zhivko, Sumiyoshi, Akira, Aoki, Ichio, Lazarova, Dessislava, Vlaykova, Tatyana, Higashi, Tatsuya, Bakalova, Rumiana

“…A considerable amount of data have accumulated in the last decade on the pronounced mitochondrial fatty acid oxidation (mFAO) in many types of cancer cells. As…”
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Targeting Glioblastoma via Selective Alteration of Mitochondrial Redox State by Sumiyoshi, Akira, Shibata, Sayaka, Zhelev, Zhivko, Miller, Thomas, Lazarova, Dessislava, Aoki, Ichio, Obata, Takayuki, Higashi, Tatsuya, Bakalova, Rumiana

“…Glioblastoma is one of the most aggressive brain tumors, characterized by a pronounced redox imbalance, expressed in a high oxidative capacity of cancer cells…”
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“Redox Imaging” to Distinguish Cells with Different Proliferative Indexes: Superoxide, Hydroperoxides, and Their Ratio as Potential Biomarkers by Bakalova, Rumiana, Gulubova, Maya, Aoki, Ichio, Semkova, Severina, Lazarova, Dessislava, Georgieva, Ekaterina, Zhelev, Zhivko, Higashi, Tatsuya

“…The present study was directed to the development of EPR methodology for distinguishing cells with different proliferative activities, using “redox imaging.”…”
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Nitroxide-enhanced magnetic resonance imaging of kidney dysfunction in vivo based on redox-imbalance and oxidative stress by Lazarova, Dessislava, Shibata, Sayaka, Ishii, Itsuko, Zlateva, Genoveva, Zhelev, Zhivko, Aoki, Ichio, Higashi, Tatsuya, Bakalova, Rumiana

“…This study reports a non-invasive magnetic resonance imaging (MRI) of kidney dysfunction in mice, based on the induction of redox-imbalance and oxidative…”
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Response of isolated thylakoid membranes with altered fluidity to short term heat stress by Velitchkova, Maya, Lazarova, Dessislava, Popova, Antoaneta

“…The effect of alterations of lipid phase order of thylakoid membranes on the thermosensitivity of photosystem I (PS I) and photosystem II (PS II) was studied…”
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