Search Results - "Lazari, Vad"

685 A highly selective and potent HPK1 inhibitor enhances immune cell activation and induces robust tumor growth inhibition in a murine syngeneic tumor model by Ciccone, David, Lazari, Vad, Linney, Ian, Briggs, Michael, Carreiro, Samantha, McElwee, Joshua, Waddell, Ian, Hill, Chris, Loh, Christine, Tummino, Peter, Collis, Alan, Kaila, Neelu

“…BackgroundHPK1, a member of the MAP4K family of protein serine/threonine kinases, is involved in regulating signal transduction cascades in cells of…”
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Abstract 1649: Mechanistic understanding of HPK1 inhibition on enhanced human T cell activation and tumor immunity in a syngeneic model by Ciccone, David, Lazari, Vad, Linney, Ian, Briggs, Michael, Carreiro, Samantha, Loh, Christine, Tummino, Peter, McElwee, Joshua, Collis, Alan, Kaila, Neelu

“…Background: HPK1, a member of the MAP4K family of protein serine/threonine kinases, is involved in negatively regulating signal transduction cascades in cells…”
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Abstract 942: HPK1, hematopoietic progenitor kinase 1, is a promising therapeutic target for cancer immunotherapy by Ciccone, David, Rocnik, Jennifer, Lazari, Vad, Linney, Ian, Briggs, Michael, Collis, Alan, Loh, Christine, Ashwell, Mark, Montana, John, Tummino, Peter, Kaila, Neelu

“…Introduction: HPK1, a member of the MAP4K family of protein serine/threonine kinases, is involved in regulating signal transduction cascades in cells of…”
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L19 Optimisation of potent, selective and brain penetrant atm inhibitors as potential therapeutic agents for HD by Toledo-Sherman, Leticia, Chachope, Roger, Rose, Mark, Munoz-Sanjuan, Ignacio, Breccia, L Perla, Bate, Jennipher, Matthews, Kimberly L, Wilshart, Grant, Vater, Hugh, Jarvis, Rebecca, Lazari, Vad, Barnes, Kate, Martin, Steve, Blackaby, Wesley, McAllister, George, Yates, Dawn, Fischer, David, Dominguez, Celia

“…Emerging evidence shows that the ATM signalling pathway is dysregulated in neurodegenerative disorders including Huntington’s disease (HD). ATM signalling has…”
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