Search Results - "Lazar, Cheri S."

type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways by Alto, Neal M, Weflen, Andrew W, Rardin, Matthew J, Yarar, Defne, Lazar, Cheri S, Tonikian, Raffi, Koller, Antonius, Taylor, Susan S, Boone, Charles, Sidhu, Sachdev S, Schmid, Sandra L, Hecht, Gail A, Dixon, Jack E

“…Bacterial toxins and effector proteins hijack eukaryotic enzymes that are spatially localized and display rapid signaling kinetics. However, the molecular…”
Get full text

The Na+/H+ exchanger regulatory factor stabilizes epidermal growth factor receptors at the cell surface by Lazar, Cheri S, Cresson, Catherine M, Lauffenburger, Douglas A, Gill, Gordon N

“…Ligand binding to cell surface receptors initiates both signal transduction and endocytosis. Although signaling may continue within the endocytic compartment,…”
Get full text

Endosomal Localization and Function of Sorting Nexin 1 by Zhong, Qi, Lazar, Cheri S., Tronchère, Hélène, Sato, Trey, Meerloo, Timo, Yeo, Michele, Songyang, Zhou, Emr, Scott D., Gill, Gordon N.

“…There are 17 human members of the sorting nexin (SNX) family of proteins that contain Phox (PX) domains. Yeast orthologs function in vesicular trafficking and…”
Get full text

A Novel Link between Fic (Filamentation Induced by cAMP)-mediated Adenylylation/AMPylation and the Unfolded Protein Response by Sanyal, Anwesha, Chen, Andy J., Nakayasu, Ernesto S., Lazar, Cheri S., Zbornik, Erica A., Worby, Carolyn A., Koller, Antonius, Mattoo, Seema

“…The maintenance of endoplasmic reticulum (ER) homeostasis is a critical aspect of determining cell fate and requires a properly functioning unfolded protein…”
Get full text

A Mutant Epidermal Growth Factor Receptor Common in Human Glioma Confers Enhanced Tumorigenicity by Nishikawa, R, Ji, X D, Harmon, R C, Lazar, C S, Gill, G N, Cavenee, W K, Huang, H J

“…The development and neoplastic progression of human astrocytic tumors appears to result through an accumulation of genetic alterations occurring in a…”
Get full text

Comparative Analysis of Histophilus somni Immunoglobulin-binding Protein A (IbpA) with Other Fic Domain-containing Enzymes Reveals Differences in Substrate and Nucleotide Specificities by Mattoo, Seema, Durrant, Eric, Chen, Mark J., Xiao, Junyu, Lazar, Cheri S., Manning, Gerard, Dixon, Jack E., Worby, Carolyn A.

“…A new family of adenylyltransferases, defined by the presence of a Fic domain, was recently discovered to catalyze the addition of adenosine monophosphate…”
Get full text

Identification of a Bacterial Type III Effector Family with G Protein Mimicry Functions by Alto, Neal M., Shao, Feng, Lazar, Cheri S., Brost, Renee L., Chua, Gordon, Mattoo, Seema, McMahon, Stephen A., Ghosh, Partho, Hughes, Timothy R., Boone, Charles, Dixon, Jack E.

“…Many bacterial pathogens use the type III secretion system to inject “effector” proteins into host cells. Here, we report the identification of a 24 member…”
Get full text

Ligand-Induced Transformation by a Noninternalizing Epidermal Growth Factor Receptor by Wells, Alan, Welsh, John B., Lazar, Cheri S., Wiley, H. Steven, Gill, Gordon N., Rosenfeld, Michael G.

“…Identification of a mutant epidermal growth factor (EGF) receptor that does not undergo downregulation has provided a genetic probe to investigate the role of…”
Get full text

Increased phosphotyrosine content and inhibition of proliferation in EGF-treated A431 cells by Gill, Gordon N, Lazar, Cheri S

Get full text

Determinants of the endosomal localization of sorting nexin 1 by Zhong, Qi, Watson, Martin J, Lazar, Cheri S, Hounslow, Andrea M, Waltho, Jonathan P, Gill, Gordon N

“…The sorting nexin (SNX) family of proteins is characterized by sequence-related phox homology (PX) domains. A minority of PX domains bind with high affinity to…”
Get full text

Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor by Chen, William S, Lazar, Cheri S, Poenie, Martin, Tsien, Roger Y, Gill, Gordon N, Rosenfeld, Michael G

“…The epidermal growth factor (EGF) receptor is a transmembrane glycoprotein of relative molecular mass 170,000 with intrinsic ligand-dependent protein tyrosine…”
Get full text

Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation by Chen, W S, Lazar, C S, Lund, K A, Welsh, J B, Chang, C P, Walton, G M, Der, C J, Wiley, H S, Gill, G N, Rosenfeld, M G

“…We have located the distal boundary of the tyrosine kinase domain of the EGF receptor and have identified a distinct sequence in the C' terminus required for…”
Get more information

Ligand-induced endocytosis of the EGF receptor is blocked by mutational inactivation and by microinjection of anti-phosphotyrosine antibodies by Glenney, Jr, J R, Chen, W S, Lazar, C S, Walton, G M, Zokas, L M, Rosenfeld, M G, Gill, G N

“…Early events in ligand-induced endocytosis of the EGF receptor have been examined. A mutant EGF receptor devoid of intrinsic protein-tyrosine kinase activity…”
Get more information

Altered Epidermal Growth Factor (EGF)-Stimulated Protein Kinase Activity in Variant A431 Cells with Altered Growth Responses to EGF by Buss, Janice E., Kudlow, Jeffrey E., Lazar, Cheri S., Gill, Gordon N.

“…To determine the role of epidermal growth factor (EGF)-stimulated protein kinase in the biological effects caused by EGF, tyrosine-specific kinase activity has…”
Get full text

Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors by CHIA-PING CHANG, LAZAR, C. S, WILEY, H. S, GILL, G. N, WALSH, B. J, KOMURO, M, COLLAWN, J. F, KUHN, L. A, TAINER, J. A, TROWBRIDGE, I. S, FARQUHAR, M. G, ROSENFELD, M. G

“…Ligand-induced internalization of epidermal growth factor (EGF) receptors via a high affinity saturable pathway requires sequences located in the carboxyl…”
Get full text

Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms by Lin, C R, Chen, W S, Lazar, C S, Carpenter, C D, Gill, G N, Evans, R M, Rosenfeld, M G

“…To test the functional consequence of phosphorylation of the EGF receptor at Thr 654 by protein kinase C, the normal Thr 654 human EGF receptor cDNA or a…”
Get more information

Phosphorylation of the epidermal growth factor receptor at threonine 654 inhibits ligand-induced internalization and down-regulation by Lund, K A, Lazar, C S, Chen, W S, Walsh, B J, Welsh, J B, Herbst, J J, Walton, G M, Rosenfeld, M G, Gill, G N, Wiley, H S

“…To assess the functional significance of phosphorylation of the epidermal growth factor (EGF) receptor at Thr654, we compared the effects of…”
Get full text

Structural analysis of the transmembrane domain of the epidermal growth factor receptor by Carpenter, C D, Ingraham, H A, Cochet, C, Walton, G M, Lazar, C S, Sowadski, J M, Rosenfeld, M G, Gill, G N

“…The ligand-binding domain of the epidermal growth factor (EGF) receptor is separated from the cytoplasmic protein tyrosine kinase domain by a predicted single…”
Get full text

Enhanced tumorigenesis of NR6 cells which express non-down-regulating epidermal growth factor receptors by MASUI, H, WELLS, A, LAZAR, C. S, ROSENFELD, M. G, GILL, G. N

“…Sequences in the regulatory carboxyl terminus of the epidermal growth factor (EGF) receptor are required for ligand-induced internalization via a high-affinity…”
Get full text

Ligand-induced internalization and increased cell calcium are mediated via distinct structural elements in the carboxyl terminus of the epidermal growth factor receptor by CHIA-PING CHANG, KAO, J. P. Y, LAZAR, C. S, WALSH, B. J, WELLS, A, STEVEN WILEY, H, GILL, G. N, ROSENFELD, M. G

“…Signals that can mediate ligand-induced receptor internalization and calcium regulation are present in a 48-amino acid "calcium-internalization" domain in the…”
Get full text