Search Results - "Lazar, Alexander J."

Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial by Tawbi, Hussein A, Burgess, Melissa, Bolejack, Vanessa, Van Tine, Brian A, Schuetze, Scott M, Hu, James, D'Angelo, Sandra, Attia, Steven, Riedel, Richard F, Priebat, Dennis A, Movva, Sujana, Davis, Lara E, Okuno, Scott H, Reed, Damon R, Crowley, John, Butterfield, Lisa H, Salazar, Ruth, Rodriguez-Canales, Jaime, Lazar, Alexander J, Wistuba, Ignacio I, Baker, Laurence H, Maki, Robert G, Reinke, Denise, Patel, Shreyaskumar

“…Patients with advanced sarcomas have a poor prognosis and few treatment options that improve overall survival. Chemotherapy and targeted therapies offer…”
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PanCancer insights from The Cancer Genome Atlas: the pathologist's perspective by Cooper, Lee AD, Demicco, Elizabeth G, Saltz, Joel H, Powell, Reid T, Rao, Arvind, Lazar, Alexander J

“…The Cancer Genome Atlas (TCGA) represents one of several international consortia dedicated to performing comprehensive genomic and epigenomic analyses of…”
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Melanoma staging: Evidence‐based changes in the American Joint Committee on Cancer eighth edition cancer staging manual by Gershenwald, Jeffrey E., Scolyer, Richard A., Hess, Kenneth R., Sondak, Vernon K., Long, Georgina V., Ross, Merrick I., Lazar, Alexander J., Faries, Mark B., Kirkwood, John M., McArthur, Grant A., Haydu, Lauren E., Eggermont, Alexander M. M., Flaherty, Keith T., Balch, Charles M., Thompson, John F., Gershenwald, Jeffrey E., Scolyer, Richard A., Atkins, Michael B., Balch, Charles M., Barnhill, Raymond L., Bilimoria, Karl Y., Buzaid, Antonio C., Byrd, David R., Cochran, Alistair J., Eggermont, Alexander M. M., Elder, David E., Faries, Mark B., Flaherty, Keith T., Garbe, Claus, Gardner, Julie M., Gimotty, Phyllis A., Halpern, Allan C., Haydu, Lauren E., Hess, Kenneth R., Johnson, Timothy M., Kirkwood, John M., Lazar, Alexander J., Lee, Anne W. M., Long, Georgina V., McArthur, Grant A., Mihm Jr, Martin C., Prieto, Victor G., Ross, Merrick I., Sober, Arthur J., Sondak, Vernon K., Thompson, John F., Wong, Sandra L., Delman, Keith A., Santinami, Mario, Maurichi, Andrea, Nagore, Eduardo, Faries, Mark B., Thompson, John F., Scolyer, Richard A., McArthur, Grant A., Gyorki, David E., Henderson, Michael, Stratigos, Alexander J., Gogas, Helen, Gershenwald, Jeffrey E., Haydu, Lauren E., Rossi, Carlo Riccardo, Sommariva, Antonio

“…Answer questions and earn CME/CNE To update the melanoma staging system of the American Joint Committee on Cancer (AJCC) a large database was assembled…”
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Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis by Wang, Yinghong, Wiesnoski, Diana H., Helmink, Beth A., Gopalakrishnan, Vancheswaran, Choi, Kati, DuPont, Hebert L., Jiang, Zhi-Dong, Abu-Sbeih, Hamzah, Sanchez, Christopher A., Chang, Chia-Chi, Parra, Edwin R., Francisco-Cruz, Alejandro, Raju, Gottumukkala S., Stroehlein, John R., Campbell, Matthew T., Gao, Jianjun, Subudhi, Sumit K., Maru, Dipen M., Blando, Jorge M., Lazar, Alexander J., Allison, James P., Sharma, Padmanee, Tetzlaff, Michael T., Wargo, Jennifer A., Jenq, Robert R.

“…We report the first case series of immune checkpoint inhibitors (ICI)-associated colitis successfully treated with fecal microbiota transplantation, with…”
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Single-cell dissection of intratumoral heterogeneity and lineage diversity in metastatic gastric adenocarcinoma by Wang, Ruiping, Dang, Minghao, Harada, Kazuto, Han, Guangchun, Wang, Fang, Pool Pizzi, Melissa, Zhao, Meina, Tatlonghari, Ghia, Zhang, Shaojun, Hao, Dapeng, Lu, Yang, Zhao, Shuangtao, Badgwell, Brian D., Blum Murphy, Mariela, Shanbhag, Namita, Estrella, Jeannelyn S., Roy-Chowdhuri, Sinchita, Abdelhakeem, Ahmed Adel Fouad, Wang, Yuanxin, Peng, Guang, Hanash, Samir, Calin, George A., Song, Xingzhi, Chu, Yanshuo, Zhang, Jianhua, Li, Mingyao, Chen, Ken, Lazar, Alexander J., Futreal, Andrew, Song, Shumei, Ajani, Jaffer A., Wang, Linghua

“…Intratumoral heterogeneity (ITH) is a fundamental property of cancer; however, the origins of ITH remain poorly understood. We performed single-cell…”
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NBTXR3, a first-in-class radioenhancer hafnium oxide nanoparticle, plus radiotherapy versus radiotherapy alone in patients with locally advanced soft-tissue sarcoma (Act.In.Sarc): a multicentre, phase 2–3, randomised, controlled trial by Bonvalot, Sylvie, PhD, Rutkowski, Piotr L, Prof, Thariat, Juliette, Prof, Carrère, Sébastien, MD, Ducassou, Anne, MD, Sunyach, Marie-Pierre, MD, Agoston, Peter, MD, Hong, Angela, MBBS, Mervoyer, Augustin, MD, Rastrelli, Marco, MD, Moreno, Victor, MD, Li, Rubi K, MD, Tiangco, Béatrice, MD, Herraez, Antonio Casado, MD, Gronchi, Alessandro, MD, Mangel, László, MD, Sy-Ortin, Teresa, MD, Hohenberger, Peter, Prof, de Baère, Thierry, Prof, Le Cesne, Axel, MD, Helfre, Sylvie, MD, Saada-Bouzid, Esma, MD, Borkowska, Aneta, MD, Anghel, Rodica, MD, Co, Ann, MD, Gebhart, Michael, Prof, Kantor, Guy, Prof, Montero, Angel, MD, Loong, Herbert H, MD, Vergés, Ramona, MD, Lapeire, Lore, MD, Dema, Sorin, MD, Kacso, Gabriel, MD, Austen, Lyn, MD, Moureau-Zabotto, Laurence, MD, Servois, Vincent, MD, Wardelmann, Eva, Prof, Terrier, Philippe, MD, Lazar, Alexander J, MD, Bovée, Judith V M G, Prof, Le Péchoux, Cécile, MD, Papai, Zsusanna, Prof

“…SummaryBackgroundPathological complete response to preoperative treatment in adults with soft-tissue sarcoma can be achieved in only a few patients receiving…”
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Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance by Chu, Yanshuo, Dai, Enyu, Li, Yating, Han, Guangchun, Pei, Guangsheng, Ingram, Davis R., Thakkar, Krupa, Qin, Jiang-Jiang, Dang, Minghao, Le, Xiuning, Hu, Can, Deng, Qing, Sinjab, Ansam, Gupta, Pravesh, Wang, Ruiping, Hao, Dapeng, Peng, Fuduan, Yan, Xinmiao, Liu, Yunhe, Song, Shumei, Zhang, Shaojun, Heymach, John V., Reuben, Alexandre, Elamin, Yasir Y., Pizzi, Melissa P., Lu, Yang, Lazcano, Rossana, Hu, Jian, Li, Mingyao, Curran, Michael, Futreal, Andrew, Maitra, Anirban, Jazaeri, Amir A., Ajani, Jaffer A., Swanton, Charles, Cheng, Xiang-Dong, Abbas, Hussein A., Gillison, Maura, Bhat, Krishna, Lazar, Alexander J., Green, Michael, Litchfield, Kevin, Kadara, Humam, Yee, Cassian, Wang, Linghua

“…Tumor-infiltrating T cells offer a promising avenue for cancer treatment, yet their states remain to be fully characterized. Here we present a single-cell…”
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The 2021 WHO Classification of Tumors of the Thymus and Mediastinum: What Is New in Thymic Epithelial, Germ Cell, and Mesenchymal Tumors? by Marx, Alexander, Chan, John K C, Chalabreysse, Lara, Dacic, Sanja, Detterbeck, Frank, French, Christopher A, Hornick, Jason L, Inagaki, Hiroshi, Jain, Deepali, Lazar, Alexander J, Marino, Mirella, Marom, Edith M, Moreira, Andre L, Nicholson, Andrew G, Noguchi, Masayuki, Nonaka, Daisuke, Papotti, Mauro G, Porubsky, Stefan, Sholl, Lynette M, Tateyama, Hisashi, Thomas de Montpréville, Vincent, Travis, William D, Rajan, Arun, Roden, Anja C, Ströbel, Philipp

“…This overview of the fifth edition of the WHO classification of thymic epithelial tumors (including thymomas, thymic carcinomas, and thymic neuroendocrine…”
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The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma by McBride, Matthew J., Pulice, John L., Beird, Hannah C., Ingram, Davis R., D’Avino, Andrew R., Shern, Jack F., Charville, Gregory W., Hornick, Jason L., Nakayama, Robert T., Garcia-Rivera, Enrique M., Araujo, Dejka M., Wang, Wei-Lien, Tsai, Jen-Wei, Yeagley, Michelle, Wagner, Andrew J., Futreal, P. Andrew, Khan, Javed, Lazar, Alexander J., Kadoch, Cigall

“…Synovial sarcoma (SS) is defined by the hallmark SS18-SSX fusion oncoprotein, which renders BAF complexes aberrant in two manners: gain of SSX to the SS18…”
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NRAS mutation status is an independent prognostic factor in metastatic melanoma by Jakob, John A., Bassett, Roland L., Ng, Chaan S., Curry, Jonathan L., Joseph, Richard W., Alvarado, Gladys C., Rohlfs, Michelle L., Richard, Jessie, Gershenwald, Jeffrey E., Kim, Kevin B., Lazar, Alexander J., Hwu, Patrick, Davies, Michael A.

“…BACKGROUND: There is a need for improved prognostic markers in melanoma. In this study, the authors tested the prognostic significance and clinicopathologic…”
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Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model by Demicco, Elizabeth G, Park, Min S, Araujo, Dejka M, Fox, Patricia S, Bassett, Roland L, Pollock, Raphael E, Lazar, Alexander J, Wang, Wei-Lien

“…Solitary fibrous tumor represents a spectrum of mesenchymal tumors, encompassing tumors previously termed hemangiopericytoma, which are classified as having…”
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American Joint Committee on Cancer acceptance criteria for inclusion of risk models for individualized prognosis in the practice of precision medicine by Kattan, Michael W., Hess, Kenneth R., Amin, Mahul B., Lu, Ying, Moons, Karl G.M., Gershenwald, Jeffrey E., Gimotty, Phyllis A., Guinney, Justin H., Halabi, Susan, Lazar, Alexander J., Mahar, Alyson L., Patel, Tushar, Sargent, Daniel J., Weiser, Martin R., Compton, Carolyn

“…The American Joint Committee on Cancer (AJCC) has increasingly recognized the need for more personalized probabilistic predictions than those delivered by…”
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Diverse clonal fates emerge upon drug treatment of homogeneous cancer cells by Goyal, Yogesh, Busch, Gianna T., Pillai, Maalavika, Li, Jingxin, Boe, Ryan H., Grody, Emanuelle I., Chelvanambi, Manoj, Dardani, Ian P., Emert, Benjamin, Bodkin, Nicholas, Braun, Jonas, Fingerman, Dylan, Kaur, Amanpreet, Jain, Naveen, Ravindran, Pavithran T., Mellis, Ian A., Kiani, Karun, Alicea, Gretchen M., Fane, Mitchell E., Ahmed, Syeda Subia, Li, Haiyin, Chen, Yeqing, Chai, Cedric, Kaster, Jessica, Witt, Russell G., Lazcano, Rossana, Ingram, Davis R., Johnson, Sarah B., Wani, Khalida, Dunagin, Margaret C., Lazar, Alexander J., Weeraratna, Ashani T., Wargo, Jennifer A., Herlyn, Meenhard, Raj, Arjun

“…Even among genetically identical cancer cells, resistance to therapy frequently emerges from a small subset of those cells 1 – 7 . Molecular differences in…”
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CXCR4/CXCL12 Mediate Autocrine Cell- Cycle Progression in NF1-Associated Malignant Peripheral Nerve Sheath Tumors by Mo, Wei, Chen, Jian, Patel, Amish, Zhang, Liang, Chau, Vincent, Li, Yanjiao, Cho, Woosung, Lim, Kyun, Xu, Jing, Lazar, Alexander J., Creighton, Chad J., Bolshakov, Svetlana, McKay, Renée M., Lev, Dina, Le, Lu Q., Parada, Luis F.

“…Malignant peripheral nerve sheath tumors (MPNSTs) are soft tissue sarcomas that arise in connective tissue surrounding peripheral nerves. They occur…”
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Synovial Sarcoma: Advances in Diagnosis and Treatment Identification of New Biologic Targets to Improve Multimodal Therapy by El Beaino, Marc, Araujo, Dejka M., Lazar, Alexander J., Lin, Patrick P.

“…Synovial sarcoma is a translocation-associated soft-tissue malignancy that frequently affects adolescents and young adults. It is driven by one of the fusion…”
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Epithelioid Inflammatory Myofibroblastic Sarcoma: An Aggressive Intra-abdominal Variant of Inflammatory Myofibroblastic Tumor With Nuclear Membrane or Perinuclear ALK by MARINO-ENRIQUEZ, Adrian, WANG, Wei-Lien, ROY, Angshumoy, LOPEZ-TERRADA, Dolores, LAZAR, Alexander J. F, FLETCHER, Christopher D. M, COFFIN, Cheryl M, HORNICK, Jason L

“…Inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm of intermediate biological potential, which may recur and rarely metastasize. Pathologic…”
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Modeling Ewing sarcoma tumors in vitro with 3D scaffolds by Fong, Eliza Li Shan, Lamhamedi-Cherradi, Salah-Eddine, Burdett, Emily, Ramamoorthy, Vandhana, Lazar, Alexander J., Kasper, F. Kurtis, Farach-Carson, Mary C., Vishwamitra, Deeksha, Demicco, Elizabeth G., Menegaz, Brian A., Amin, Hesham M., Mikos, Antonios G., Ludwig, Joseph A.

“…The pronounced biological influence of the tumor microenvironment on cancer progression and metastasis has gained increased recognition over the past decade,…”
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Extensive Survey of STAT6 Expression in a Large Series of Mesenchymal Tumors by Demicco, Elizabeth G., Harms, Paul W., Patel, Rajiv M., Smith, Steven C., Ingram, Davis, Torres, Keila, Carskadon, Shannon L., Camelo-Piragua, Sandra, McHugh, Jonathan B., Siddiqui, Javed, Palanisamy, Nallasivam, Lucas, David R., Lazar, Alexander J., Wang, Wei-Lien

“…Objectives: Expression of strong nuclear STAT6 is thought to be a specific marker for solitary fibrous tumors (SFTs). Little is known about subtle expression…”
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The International Collaboration for Cancer Classification and Research by Cree, Ian A., Indave Ruiz, Blanca Iciar, Zavadil, Jiri, McKay, James, Olivier, Magali, Kozlakidis, Zisis, Lazar, Alexander J., Hyde, Chris, Holdenrieder, Stefan, Hastings, Ros, Rajpoot, Nasir, Fouchardiere, Arnaud, Rous, Brian, Zenklusen, Jean Claude, Normanno, Nicola, Schilsky, Richard L.

“…Gaps in the translation of research findings to clinical management have been recognized for decades. They exist for the diagnosis as well as the management of…”
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Molecular profiling of patient-matched brain and extracranial melanoma metastases implicates the PI3K pathway as a therapeutic target by Chen, Guo, Chakravarti, Nitin, Aardalen, Kimberly, Lazar, Alexander J, Tetzlaff, Michael T, Wubbenhorst, Bradley, Kim, Sang-Bae, Kopetz, Scott, Ledoux, Alicia A, Gopal, Y N Vashisht, Pereira, Cristiano Goncalves, Deng, Wanleng, Lee, Ju-Seog, Nathanson, Katherine L, Aldape, Kenneth D, Prieto, Victor G, Stuart, Darrin, Davies, Michael A

“…An improved understanding of the molecular pathogenesis of brain metastases, one of the most common and devastating complications of advanced melanoma, may…”
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