Search Results - "Layton, D."

How we manage patients with pyruvate kinase deficiency by Grace, Rachael F., Mark Layton, D., Barcellini, Wilma

“…Summary Novel therapies in development have brought a new focus on pyruvate kinase deficiency (PKD), the most common congenital haemolytic anaemia due to a…”
Get full text

Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency by Grace, Rachael F, Rose, Christian, Layton, D. Mark, Galactéros, Frédéric, Barcellini, Wilma, Morton, D. Holmes, van Beers, Eduard J, Yaish, Hassan, Ravindranath, Yaddanapudi, Kuo, Kevin H.M, Sheth, Sujit, Kwiatkowski, Janet L, Barbier, Ann J, Bodie, Susan, Silver, Bruce, Hua, Lei, Kung, Charles, Hawkins, Peter, Jouvin, Marie-Hélène, Bowden, Chris, Glader, Bertil

“…In this study, approximately half the patients with red-cell pyruvate kinase deficiency who were treated with mitapivat had an improvement in their hemoglobin…”
Get full text

Safety and efficacy of mitapivat, an oral pyruvate kinase activator, in adults with non-transfusion dependent α-thalassaemia or β-thalassaemia: an open-label, multicentre, phase 2 study by Kuo, Kevin H M, Layton, D Mark, Lal, Ashutosh, Al-Samkari, Hanny, Bhatia, Joy, Kosinski, Penelope A, Tong, Bo, Lynch, Megan, Uhlig, Katrin, Vichinsky, Elliott P

“…Patients with non-transfusion-dependent thalassaemia (NTDT), although they do not require regular blood transfusions for survival, can still accrue a heavy…”
Get full text

Putting unstable hemoglobins on the map of London by Bain, Barbara J., Hann, Amanda, Layton, D. Mark

Get full text

A phase 1/2 ascending dose study and open-label extension study of voxelotor in patients with sickle cell disease by Howard, Jo, Hemmaway, Claire Jane, Telfer, Paul, Layton, D. Mark, Porter, John, Awogbade, Moji, Mant, Timothy, Gretler, Daniel D., Dufu, Kobina, Hutchaleelaha, Athiwat, Patel, Mira, Siu, Vincent, Dixon, Sandra, Landsman, Noel, Tonda, Margaret, Lehrer-Graiwer, Joshua

“…New treatments directly targeting polymerization of sickle hemoglobin (HbS), the proximate event in the pathophysiology of sickle cell disease (SCD), are…”
Get full text

Voxelotor in sickle cell disease by Bain, Barbara J., Myburgh, Jane, Hann, Amanda, Layton, D. Mark

Get full text

Mitapivat versus Placebo for Pyruvate Kinase Deficiency by Al-Samkari, Hanny, Galactéros, Frédéric, Glenthøj, Andreas, Rothman, Jennifer A, Andres, Oliver, Grace, Rachael F, Morado-Arias, Marta, Layton, D. Mark, Onodera, Koichi, Verhovsek, Madeleine, Barcellini, Wilma, Chonat, Satheesh, Judge, Malia P, Zagadailov, Erin, Xu, Rengyi, Hawkins, Peter, Beynon, Vanessa, Gheuens, Sarah, van Beers, Eduard J

“…Pyruvate kinase deficiency, the most common genetic lesion in the glycolytic pathway, leads to chronic hemolytic anemia. Mitapivat, an oral agent, can activate…”
Get full text

Peripheral blood features of iron overload in post‐splenectomy, type I congenital dyserythropoietic anemia by Dexter, Daniel, Layton, D. Mark, Kiritkumar, Kripesh, Bain, Barbara J.

Get full text

Low serum haptoglobin and blood films suggest intravascular hemolysis contributes to severe anemia in hereditary hemorrhagic telangiectasia by Thielemans, Lieze, Layton, D Mark, Shovlin, Claire L

Get full text

Real-time national survey of COVID-19 in hemoglobinopathy and rare inherited anemia patients by Telfer, Paul, De la Fuente, Josu, Sohal, Mamta, Brown, Ralph, Eleftheriou, Perla, Roy, Noémi, Piel, Frédéric B, Chakravorty, Subarna, Gardner, Kate, Velangi, Mark, Drasar, Emma, Shah, Farrukh, Porter, John B, Trompeter, Sara, Atoyebi, Wale, Szydlo, Richard, Anie, Kofi A, Ryan, Kate, Sharif, Joseph, Wright, Josh, Astwood, Emma, Nicolle, C Sarah, Webster, Amy, Roberts, David J, Lugthart, Sanne, Kaya, Banu, Awogbade, Moji, Rees, David C, Hollingsworth, Rob, Inusa, Baba, Howard, Jo, Layton, D Mark

Get full text

Protecting vulnerable patients with inherited anaemias from unnecessary death during the COVID‐19 pandemic by Roy, Noémi B. A., Telfer, Paul, Eleftheriou, Perla, de la Fuente, Josu, Drasar, Emma, Shah, Farrukh, Roberts, David, Atoyebi, Wale, Trompeter, Sara, Layton, D. Mark, Lugthart, Sanne, Stuart‐Smith, Sara, Chakravorty, Subarna, Wright, Josh, Porter, John, Inusa, Baba, Howard, Jo

“…Summary With the developing COVID‐19 pandemic, patients with inherited anaemias require specific advice regarding isolation and changes to usual treatment…”
Get full text

Bone mineral density in adult patients with pyruvate kinase deficiency on long-term mitapivat treatment by Al-Samkari, Hanny, Grace, Rachael F, Glenthøj, Andreas, Andres, Oliver, Barcellini, Wilma, Galacteros, Frédéric, Kuo, Kevin H M, Layton, D Mark, Morado, Marta, Viprakasit, Vip, Tai, Feng, Urbstonaitis, Rolandas, Morales, Jaime, McGee, Bryan, Beers, Eduard J van

Get full text

CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells by James, Charlotte A., Xu, Yuexin, Aguilar, Melissa S., Jing, Lichen, Layton, Erik D., Gilleron, Martine, Minnaard, Adriaan J., Scriba, Thomas J., Day, Cheryl L., Warren, Edus H., Koelle, David M., Seshadri, Chetan

“…T cells recognize mycobacterial glycolipid (mycolipid) antigens presented by CD1b molecules, but the role of CD4 and CD8 co-receptors in mycolipid recognition…”
Get full text

Congenital sideroblastic anemia in a female by Hanina, Sophie, Bain, Barbara J., Clark, Barnaby, Layton, D. Mark

Get full text

Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology by Smith, Thomas G, Brooks, Jerome T, Balanos, George M, Lappin, Terence R, Layton, D Mark, Leedham, Dawn L, Liu, Chun, Maxwell, Patrick H, McMullin, Mary F, McNamara, Christopher J, Percy, Melanie J, Pugh, Christopher W, Ratcliffe, Peter J, Talbot, Nick P, Treacy, Marilyn, Robbins, Peter A

“…The von Hippel-Lindau tumour suppressor protein-hypoxia-inducible factor (VHL-HIF) pathway has attracted widespread medical interest as a transcriptional…”
Get full text

The Pyruvate Kinase Deficiency Global Longitudinal (Peak) Registry: rationale and study design by Grace, Rachael F, van Beers, Eduard J, Vives Corrons, Joan-Lluis, Glader, Bertil, Glenthøj, Andreas, Kanno, Hitoshi, Kuo, Kevin H M, Lander, Carl, Layton, D Mark, Pospíŝilová, Dagmar, Viprakasit, Vip, Li, Junlong, Yan, Yan, Boscoe, Audra N, Bowden, Chris, Bianchi, Paola

“…IntroductionPyruvate kinase (PK) deficiency is a rare, under-recognised, hereditary condition that leads to chronic haemolytic anaemia and potentially serious…”
Get full text

A puzzling case of methemoglobinemia by Morris, Audrey, Bain, Barbara J, Atta, Maria, Layton, D Mark

Get full text

Validation of a CD1b tetramer assay for studies of human mycobacterial infection or vaccination by Layton, Erik D., Yu, Krystle K.Q., Smith, Malisa T., Scriba, Thomas J., De Rosa, Stephen C., Seshadri, Chetan

“…CD1 tetramers loaded with lipid antigens facilitate the identification of rare lipid-antigen specific T cells present in human blood and tissue. Because CD1…”
Get full text

Tissue-Resident-Memory CD8 + T Cells Bridge Innate Immune Responses in Neighboring Epithelial Cells to Control Human Genital Herpes by Peng, Tao, Phasouk, Khamsone, Sodroski, Catherine N, Sun, Sijie, Hwangbo, Yon, Layton, Erik D, Jin, Lei, Klock, Alexis, Diem, Kurt, Magaret, Amalia S, Jing, Lichen, Laing, Kerry, Li, Alvason, Huang, Meei-Li, Mertens, Max, Johnston, Christine, Jerome, Keith R, Koelle, David M, Wald, Anna, Knipe, David M, Corey, Lawrence, Zhu, Jia

“…Tissue-resident-memory T cells (TRM) populate the body's barrier surfaces, functioning as frontline responders against reencountered pathogens. Understanding…”
Get full text

Quality of reporting of dental survival analyses by Layton, D. M., Clarke, M.

“…Summary To explore the quality of reporting (writing and graphics) of articles that used time‐to‐event analyses to report dental treatment outcomes. A…”
Get full text