Search Results - "Layland, Shannon"

The role of extracellular matrix in biomechanics and its impact on bioengineering of cells and 3D tissues by Urbanczyk, Max, Layland, Shannon L., Schenke-Layland, Katja

“…The cells and tissues of the human body are constantly exposed to exogenous and endogenous forces that are referred to as biomechanical cues. They guide and…”
Get full text

Forward programming of hiPSCs towards beta-like cells using Ngn3, Pdx1, and MafA by Jeyagaran, Abiramy, Urbanczyk, Max, Layland, Shannon L., Weise, Frank, Schenke-Layland, Katja

“…Transplantation of stem cell-derived β-cells is a promising therapeutic advancement in the treatment of type 1 diabetes mellitus. A current limitation of this…”
Get full text

Type 1 diabetes and engineering enhanced islet transplantation by Jeyagaran, Abiramy, Lu, Chuan-En, Zbinden, Aline, Birkenfeld, Andreas L, Brucker, Sara Y, Layland, Shannon L

“…The development of new therapeutic approaches to treat type 1 diabetes mellitus (T1D) relies on the precise understanding and deciphering of insulin-secreting…”
Get full text

ECM and ECM-like materials — Biomaterials for applications in regenerative medicine and cancer therapy by Hinderer, Svenja, Layland, Shannon Lee, Schenke-Layland, Katja

“…Regenerative strategies such as stem cell-based therapies and tissue engineering applications are being developed with the aim to replace, remodel, regenerate…”
Get full text

Non-invasive marker-independent high content analysis of a microphysiological human pancreas-on-a-chip model by Zbinden, Aline, Marzi, Julia, Schlünder, Katharina, Probst, Christopher, Urbanczyk, Max, Black, Scott, Brauchle, Eva M., Layland, Shannon L., Kraushaar, Udo, Duffy, Garry, Schenke-Layland, Katja, Loskill, Peter

“…The increasing prevalence of diabetes, its heterogeneity, and the limited number of treatment options drive the need for physiologically relevant assay…”
Get full text

Basement membrane proteins improve human islet survival in hypoxia: Implications for islet inflammation by Brandhorst, Daniel, Brandhorst, Heide, Lee Layland, Shannon, Acreman, Samuel, Schenke-Layland, Katja, Johnson, Paul R.V.

“…Enzymatic digestion of the pancreas during islet isolation is associated with disintegration of the islet basement membrane (IBM) that can cause reduction of…”
Get full text

Raman microspectroscopy identifies fibrotic tissues in collagen-related disorders via deconvoluted collagen type I spectra by Becker, Lucas, Lu, Chuan-En, Montes-Mojarro, Ivonne A., Layland, Shannon L., Khalil, Suzan, Nsair, Ali, Duffy, Garry P., Fend, Falko, Marzi, Julia, Schenke-Layland, Katja

“…Fibrosis is a consequence of the pathological remodeling of extracellular matrix (ECM) structures in the connective tissue of an organ. It is often caused by…”
Get full text

Decorin improves human pancreatic β-cell function and regulates ECM expression in vitro by Urbanczyk, Max, Jeyagaran, Abiramy, Zbinden, Aline, Lu, Chuan-en, Marzi, Julia, Kuhlburger, Laurence, Nahnsen, Sven, Layland, Shannon L., Duffy, Garry, Schenke-Layland, Katja

“…•Treatment with recombinantly-produced DCN results in a significant upregulation of glucose-stimulated insulin secretion of human β-cells in…”
Get full text

Endocardial-to-mesenchymal transformation and mesenchymal cell colonization at the onset of human cardiac valve development by Monaghan, Michael G, Linneweh, Miriam, Liebscher, Simone, Van Handel, Ben, Layland, Shannon L, Schenke-Layland, Katja

“…The elucidation of mechanisms in semilunar valve development might enable the development of new therapies for congenital heart disorders. Here, we found…”
Get full text

Hyaluronic Acid-Functionalized Hybrid Gelatin-Poly-L-Lactide Scaffolds with Tunable Hydrophilicity by Piccirillo, Germano, Feuerer, Nora, Carvajal Berrio, Daniel A, Layland, Shannon L, Reimer Hinderer, Svenja, Bochicchio, Brigida, Schenke-Layland, Katja

“…In this study, we describe the production of hybrid gelatin-poly-L-lactide electrospun scaffolds whose hydrophilicity was controlled by binding increasing…”
Get more information

Raman Imaging and Fluorescence Lifetime Imaging Microscopy for Diagnosis of Cancer State and Metabolic Monitoring by Becker, Lucas, Janssen, Nicole, Layland, Shannon L., Mürdter, Thomas E., Nies, Anne T., Schenke-Layland, Katja, Marzi, Julia

“…Hurdles for effective tumor therapy are delayed detection and limited effectiveness of systemic drug therapies by patient-specific multidrug resistance…”
Get full text

Cardiomyocyte generation from somatic sources — current status and future directions by Monaghan, Michael G, Holeiter, Monika, Layland, Shannon L, Schenke-Layland, Katja

“…Graphical abstract Direct reprogramming of fibroblasts to a functional cardiomyocyte with or without a progenitor cell intermediate has been widely reported…”
Get full text

Noninvasive Physical Plasma as Innovative and Tissue-Preserving Therapy for Women Positive for Cervical Intraepithelial Neoplasia by Marzi, Julia, Stope, Matthias B, Henes, Melanie, Koch, André, Wenzel, Thomas, Holl, Myriam, Layland, Shannon L, Neis, Felix, Bösmüller, Hans, Ruoff, Felix, Templin, Markus, Krämer, Bernhard, Staebler, Annette, Barz, Jakob, Carvajal Berrio, Daniel A, Enderle, Markus, Loskill, Peter M, Brucker, Sara Y, Schenke-Layland, Katja, Weiss, Martin

“…(1) Background: Cervical intraepithelial neoplasia (CIN) of long-term persistence or associated with individual treatment indications often requires highly…”
Get full text

ECM Proteins Nidogen‐1 and Decorin Restore Functionality of Human Islets of Langerhans upon Hypoxic Conditions by Jeyagaran, Abiramy, Urbanczyk, Max, Carvajal‐Berrio, Daniel, Baldissera, Teresa, Kaiser, Philipp D., Kuhlburger, Laurence, Czemmel, Stefan, Nahnsen, Sven, Duffy, Garry P., Brucker, Sara Y., Layland, Shannon L., Schenke‐Layland, Katja

“…Abstract Transplantation of donor islets of Langerhans is a potential therapeutic approach for patients with diabetes mellitus; however, its success is limited…”
Get full text

Non-invasive Chamber-Specific Identification of Cardiomyocytes in Differentiating Pluripotent Stem Cells by Brauchle, Eva, Knopf, Anne, Bauer, Hannah, Shen, Nian, Linder, Sandra, Monaghan, Michael G., Ellwanger, Kornelia, Layland, Shannon L., Brucker, Sara Y., Nsair, Ali, Schenke-Layland, Katja

“…One major obstacle to the application of stem cell-derived cardiomyocytes (CMs) for disease modeling and clinical therapies is the inability to identify the…”
Get full text

Monitoring the macrophage response towards biomaterial implants using label-free imaging by Lu, Chuan-en, Levey, Ruth E., Ghersi, Giulio, Schueller, Nathan, Liebscher, Simone, Layland, Shannon L., Schenke-Layland, Katja, Duffy, Garry P., Marzi, Julia

“…Understanding the immune system's foreign body response (FBR) is essential when developing and validating a biomaterial. Macrophage activation and…”
Get full text

The Foreign Body Response to an Implantable Therapeutic Reservoir in a Diabetic Rodent Model by Beatty, Rachel, Lu, Chuan-En, Marzi, Julia, Levey, Ruth E, Carvajal Berrio, Daniel, Lattanzi, Giulia, Wylie, Robert, O'Connor, Raymond, Wallace, Eimear, Ghersi, Giulio, Salamone, Monica, Dolan, Eimear B, Layland, Shannon L, Schenke-Layland, Katja, Duffy, Garry P

“…Advancements in type 1 diabetes mellitus treatments have vastly improved in recent years. The move toward a bioartificial pancreas and other fully implantable…”
Get more information

Nidogen‐1 Mitigates Ischemia and Promotes Tissue Survival and Regeneration by Zbinden, Aline, Layland, Shannon L., Urbanczyk, Max, Carvajal Berrio, Daniel A., Marzi, Julia, Zauner, Monika, Hammerschmidt, Anne, Brauchle, Eva M., Sudrow, Katrin, Fink, Simon, Templin, Markus, Liebscher, Simone, Klein, Gerd, Deb, Arjun, Duffy, Garry P., Crooks, Gay M., Eble, Johannes A., Mikkola, Hanna K. A., Nsair, Ali, Seifert, Martina, Schenke‐Layland, Katja

“…Ischemia impacts multiple organ systems and is the major cause of morbidity and mortality in the developed world. Ischemia disrupts tissue homeostasis, driving…”
Get full text

Fluorescence lifetime metabolic mapping of hypoxia‐induced damage in pancreatic pseudo‐islets by Zbinden, Aline, Carvajal Berrio, Daniel A., Urbanczyk, Max, Layland, Shannon L., Bosch, Mariella, Fliri, Sandro, Lu, Chuan‐en, Jeyagaran, Abiramy, Loskill, Peter, Duffy, Garry P., Schenke‐Layland, Katja

“…Pancreatic islet isolation from donor pancreases is an essential step for the transplantation of insulin‐secreting β‐cells as a therapy to treat type 1…”
Get full text

A flow bioreactor system compatible with real-time two-photon fluorescence lifetime imaging microscopy by Shen, Nian, Riedl, Julia A, Carvajal Berrio, Daniel A, Davis, Zachary, Monaghan, Michael G, Layland, Shannon L, Hinderer, Svenja, Schenke-Layland, Katja

“…Bioreactors are essential cell and tissue culture tools that allow the introduction of biophysical signals into in vitro cultures. One major limitation is the…”
Get more information