Search Results - "Layland, Laura E."

Impact of the use of GeneXpert on TB diagnosis and anti-TB treatment outcome at health facilities in Addis Ababa, Ethiopia in the post-millennium development years by Getahun, Desalegn Addise, Layland, Laura E, Hoerauf, Achim, Wondale, Biniam

“…Background GeneXpert is an effective and rapid molecular system used for tuberculosis (TB) diagnosis. It is expected to improve the detection rate and…”
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Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses by Ritter, Manuel, Gross, Olaf, Kays, Sarah, Ruland, Jürgen, Nimmerjahn, Falk, Saijo, Shinobu, Tschopp, Jürg, Layland, Laura E., Costa, Clarissa Prazeres da, Medzhitov, Ruslan

“…The propensity of helminths, such as schistosomes, to immunomodulate the host's immune system is an essential aspect of their survival. Previous research has…”
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Maternal immune response to helminth infection during pregnancy determines offspring susceptibility to allergic airway inflammation by Straubinger, Kathrin, PhD, Paul, Sabine, VTA, Prazeres da Costa, Olivia, MSc, Ritter, Manuel, PhD, Buch, Thorsten, PhD, Busch, Dirk H., MD, Layland, Laura E., PhD, Prazeres da Costa, Clarissa U., MD

“…Background Schistosomiasis, a chronic helminth infection, elicits distinct immune responses within the host, ranging from an initial TH 1 and subsequent TH 2…”
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Wuchereria bancrofti-infected individuals harbor distinct IL-10-producing regulatory B and T cell subsets which are affected by anti-filarial treatment by Ritter, Manuel, Osei-Mensah, Jubin, Debrah, Linda Batsa, Kwarteng, Alexander, Mubarik, Yusif, Debrah, Alexander Y, Pfarr, Kenneth, Hoerauf, Achim, Layland, Laura E

“…Despite worldwide mass drug administration, it is estimated that 68 million individuals are still infected with lymphatic filariasis with 19 million hydrocele…”
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Induction of Siglec-FhiCD101hi eosinophils in the lungs following murine hookworm Nippostrongylus brasiliensis infection by Chetty, Alisha, Darby, Matthew G., Pillaye, Jamie, Taliep, A'ishah, Cunningham, Adam F., O’Shea, Matthew K., Katawa, Gnatoulma, Layland, Laura E., Ritter, Manuel, Horsnell, William G. C.

“…Helminth-induced eosinophils accumulate around the parasite at the site of infection, or in parasite-damaged tissues well after the helminth has left the site…”
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Schistosoma mansoni-mediated suppression of allergic airway inflammation requires patency and Foxp3+ Treg cells by Layland, Laura E, Straubinger, Kathrin, Ritter, Manuel, Loffredo-Verde, Eva, Garn, Holger, Sparwasser, Tim, Prazeres da Costa, Clarissa

“…The continual rise of asthma in industrialised countries stands in strong contrast to the situation in developing lands. According to the modified Hygiene…”
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Chronic filarial infection provides protection against bacterial sepsis by functionally reprogramming macrophages by Gondorf, Fabian, Berbudi, Afiat, Buerfent, Benedikt C, Ajendra, Jesuthas, Bloemker, Dominique, Specht, Sabine, Schmidt, David, Neumann, Anna-Lena, Layland, Laura E, Hoerauf, Achim, Hübner, Marc P

“…Helminths immunomodulate their hosts and induce a regulatory, anti-inflammatory milieu that prevents allergies and autoimmune diseases. Helminth…”
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Mansonella perstans microfilaremic individuals are characterized by enhanced type 2 helper T and regulatory T and B cell subsets and dampened systemic innate and adaptive immune responses by Ritter, Manuel, Ndongmo, Winston Patrick Chounna, Njouendou, Abdel Jelil, Nghochuzie, Nora Nganyewo, Nchang, Lucy Cho, Tayong, Dizzle Bita, Arndts, Kathrin, Nausch, Norman, Jacobsen, Marc, Wanji, Samuel, Layland, Laura E, Hoerauf, Achim

“…The filarial nematode Mansonella perstans is endemic throughout Africa, northern South America and the Caribbean. Interestingly, M. perstans-infected…”
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Adoptive Transfer of Immune Cells Into RAG2IL-2Rγ-Deficient Mice During Litomosoides sigmodontis Infection: A Novel Approach to Investigate Filarial-Specific Immune Responses by Wiszniewsky, Anna, Layland, Laura E, Arndts, Kathrin, Wadephul, Lisa M, Tamadaho, Ruth S E, Borrero-Wolff, Dennis, Chunda, Valerine C, Kien, Chi Anizette, Hoerauf, Achim, Wanji, Samuel, Ritter, Manuel

“…Despite long-term mass drug administration programmes, approximately 220 million people are still infected with filariae in endemic regions. Several research…”
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Hyperreactive onchocerciasis is characterized by a combination of Th17-Th2 immune responses and reduced regulatory T cells by Katawa, Gnatoulma, Layland, Laura E, Debrah, Alex Y, von Horn, Charlotte, Batsa, Linda, Kwarteng, Alexander, Arriens, Sandra, W Taylor, David, Specht, Sabine, Hoerauf, Achim, Adjobimey, Tomabu

“…Clinical manifestations in onchocerciasis range from generalized onchocerciasis (GEO) to the rare but severe hyperreactive (HO)/sowda form. Since disease…”
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TLRs, Treg, and B Cells, an Interplay of Regulation during Helminth Infection by Ludwig-Portugall, Isis, Layland, Laura E

“…Commonly described as masters of regulation parasitic helminth infections provide a fascinating insight into the complexity of our immune system. As with many…”
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Distinct Immune Profiles of Exhausted Effector and Memory CD8+ T Cells in Individuals With Filarial Lymphedema by Horn, Sacha, Borrero-Wolff, Dennis, Ritter, Manuel, Arndts, Kathrin, Wiszniewsky, Anna, Debrah, Linda Batsa, Debrah, Alexander Y., Osei-Mensah, Jubin, Chachage, Mkunde, Hoerauf, Achim, Kroidl, Inge, Layland, Laura E.

“…CD8 + T cells are crucial for the clearance of viral infections, and current research begins to highlight their importance in parasitic diseases too. In-depth…”
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Immunopathology in schistosomiasis is controlled by antigen‐specific regulatory T cells primed in the presence of TLR2 by Layland, Laura E., Rad, Roland, Wagner, Hermann, da Costa, Clarissa U. Prazeres

“…Regulatory T cells (Treg) are vital in maintaining the homeostasis of immune reactions. In chronic infections, such as schistosomiasis, it remains unclear…”
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Hookworm infection associates with a vaginal Type 1/Type 2 immune signature and increased HPV load by Omondi, Millicent A, Kamassa, Eya H, Katawa, Gnatoulma, Tchopba, Christèle N, Vogelbusch, Celina, Parcina, Marijo, Tchadié, Edlom P, Amessoudji, Oukoe M, Arndts, Kathrin, Karou, Simplice D, Ameyapoh, Yaovi, Kolou, Malewé, Hoerauf, Achim, Layland, Laura E, Horsnell, William G C, Ritter, Manuel

“…Helminth infection-driven changes to immunity in the female reproductive tract (FRT) is an immune axis that is currently understudied but can have major…”
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Filarial Lymphedema Patients Are Characterized by Exhausted CD4 + T Cells by Horn, Sacha, Ritter, Manuel, Arndts, Kathrin, Borrero-Wolff, Dennis, Wiszniewsky, Anna, Debrah, Linda Batsa, Debrah, Alexander Y, Osei-Mensah, Jubin, Chachage, Mkunde, Hoerauf, Achim, Kroidl, Inge, Layland, Laura E

“…Worldwide, more than 200 million people are infected with filariae which can cause severe symptoms leading to reduced quality of life and contribute to…”
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Anti-Th17 and anti-Th2 responses effects of hydro-ethanolic extracts of Aframomum melegueta, Khaya senegalensis and Xylopia aethiopica in hyperreactive onchocerciasis individuals' peripheral blood mononuclear cells by Katawa, Gnatoulma, Ataba, Essoham, Ritter, Manuel, Amessoudji, Oukoe Marthe, Awesso, Essimanam Rosalie, Tchadié, Pélagie Edlom, Bara, Fagdéba David, Douti, Fekandine Victoire, Arndts, Kathrin, Tchacondo, Tchadjobo, Batawila, Komlan, Ameyapoh, Yaovi, Hoerauf, Achim, Karou, Simplice D, Layland, Laura E

“…Hyperreactive onchocerciasis (HO) is characterized by a severe skin inflammation with elevated Th17-Th2 combined responses. We previously demonstrated the…”
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Update on the biology and ecology of Culicoides species in the South-West region of Cameroon with implications on the transmission of Mansonella perstans by Wanji, Samuel, Tayong, Dizzle Bita, Ebai, Rene, Opoku, Vera, Kien, Chi Anizette, Ndongmo, Winston Patrick Chounna, Njouendou, Abdel Jelil, Ghani, Raymond Nsaidzedze, Ritter, Manuel, Debrah, Yaw Alex, Layland, Laura E, Enyong, Peter A, Hoerauf, Achim

“…Culicoides (Diptera; Ceratoponidae) are tiny, stout, blood-sucking flies with a near worldwide distribution. When present, they are often considered a biting…”
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Pathological manifestations in lymphatic filariasis correlate with lack of inhibitory properties of IgG4 antibodies on IgE-activated granulocytes by Prodjinotho, Ulrich F, von Horn, Charlotte, Debrah, Alex Y, Batsa Debrah, Linda, Albers, Anna, Layland, Laura E, Hoerauf, Achim, Adjobimey, Tomabu

“…Helminth parasites are known to be efficient modulators of their host's immune system. To guarantee their own survival, they induce alongside the classical Th2…”
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Successful long-term maintenance of Mansonella perstans in an in vitro culture system by Njouendou, Abdel Jelil, Ritter, Manuel, Ndongmo, Winston Patrick Chounna, Kien, Chi Anizette, Narcisse, Gandjui Tchamatchoua Victor, Fombad, Fanny Fri, Tayong, Dizzle Bita, Pfarr, Kenneth, Layland, Laura E, Hoerauf, Achim, Wanji, Samuel

“…Approximately 114 million people are infected with Mansonella perstans in large proportions of Africa. In contrast to other filariae that infect humans, M…”
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Dectin-1/2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses by Kaisar, Maria M M, Ritter, Manuel, Del Fresno, Carlos, Jónasdóttir, Hulda S, van der Ham, Alwin J, Pelgrom, Leonard R, Schramm, Gabriele, Layland, Laura E, Sancho, David, Prazeres da Costa, Clarissa, Giera, Martin, Yazdanbakhsh, Maria, Everts, Bart

“…The molecular mechanisms through which dendritic cells (DCs) prime T helper 2 (Th2) responses, including those elicited by parasitic helminths, remain…”
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