Search Results - "Layko, Debra B."

Editor's Highlight: Complete Attenuation of Mouse Lung Cell Proliferation and Tumorigenicity in CYP2F2 Knockout and CYP2F1 Humanized Mice Exposed to Inhaled Styrene for up to 2 Years Supports a Lack of Human Relevance by Cruzan, George, Bus, James S, Banton, Marcy I, Sarang, Satinder S, Waites, Robbie, Layko, Debra B, Raymond, James, Dodd, Darol, Andersen, Melvin E

“…Styrene is a mouse-specific lung carcinogen, and short-term mode of action studies have demonstrated that cytotoxicity and/or cell proliferation, and genomic…”
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Strain-related differences in mouse lung gene expression over a two-year period of inhalation exposure to styrene: Relevance to human risk assessment by Andersen, Melvin E., Cruzan, George, Black, Michael B., Pendse, Salil N., Dodd, Darol E., Bus, James S., Sarang, Satinder S., Banton, Marcy I., Waites, Robbie, Layko, Debra B., McMullen, Patrick D.

“…Both CD-1 and C57BL/6 wildtype (C57BL/6-WT) mice show equivalent short-term lung toxicity from exposures to styrene, while long-term tumor responses are…”
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