Search Results - "Laxton, Ross C"

Advanced Glycation End-Product of Low Density Lipoprotein Activates the Toll-Like 4 Receptor Pathway Implications for Diabetic Atherosclerosis by Hodgkinson, Conrad P, Laxton, Ross C, Patel, Kunal, Ye, Shu

“…OBJECTIVE—Diabetes is a major risk factor for coronary heart disease. Accumulation of advanced glycation end-products (AGEs) attributable to hyperglycemia in…”
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A Role of Matrix Metalloproteinase-8 in Atherosclerosis by Laxton, Ross C, Hu, Yanhua, Duchene, Johan, Zhang, Feng, Zhang, Zhongyi, Leung, Kit-Yi, Xiao, Qingzhong, Scotland, Ramona S, Hodgkinson, Conrad P, Smith, Katherine, Willeit, Johann, López-Otín, Carlos, Simpson, Iain A, Kiechl, Stefan, Ahluwalia, Amrita, Xu, Qingbo, Ye, Shu

“…RATIONALE:Atherosclerotic lesions express matrix metalloproteinase (MMP)8, which possesses proteolytic activity on matrix proteins particularly fibrillar…”
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Common Variant on Chromosome 9p21 Predicts Severity of Coronary Artery Disease by Chan, Kenneth, MPharm, Motterle, Anna, MSc, Laxton, Ross C., BSc, Ye, Shu, MD, PhD

“…[...]the results of our study support that there is an association between 9p21 and CAD severity, arguing for the notion that the 9p21 variant predisposes to…”
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Functional polymorphism in ABCA1 influences age of symptom onset in coronary artery disease patients by Kyriakou, Theodosios, Pontefract, David E., Viturro, Enrique, Hodgkinson, Conrad P., Laxton, Ross C., Bogari, Neda, Cooper, George, Davies, Michael, Giblett, Joel, Day, Ian N.M., Simpson, Iain A., Albrecht, Christiane, Ye, Shu

“…ATP-binding-cassette-transporter-A1 (ABCA1) plays a pivotal role in intracellular cholesterol removal, exerting a protective effect against atherosclerosis…”
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Haplotype Effects on Matrix Metalloproteinase-1 Gene Promoter Activity in Cancer Cells by Pearce, Eve G, Laxton, Ross C, Pereira, Andresa C, Ye, Shu

“…Increased expression of matrix metalloproteinase-1 (MMP1) is associated with poor prognosis in cancers. Several single nucleotide polymorphisms (−1607GG>G,…”
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Association Between the Chromosome 9p21 Locus and Angiographic Coronary Artery Disease Burden: A Collaborative Meta-Analysis by CHAN, Kenneth, PATEL, Riyaz S, ANDERSON, Jeffrey L, CARLQUIST, John F, HARTIALA, Jaana, ALLAYEE, Hooman, HINOHARA, Kunihiko, LEE, Bok-Soo, ERL, Anna, ELLIS, Katrina L, GOEL, Anuj, SCHAEFER, Arne S, NEWCOMBE, Paul, EL MOKHTARI, Nour Eddine, GOLDSTEIN, Benjamin A, HLATKY, Mark A, GO, Alan S, SHEN, Gong-Qing, YAN GONG, PEPINE, Carl, LAXTON, Ross C, WHITTAKER, John C, TANG, Wilson, NELSON, Christopher P, JOHNSON, Julie A, WANG, Qing K, ASSIMES, Themistocles L, NOTHLINGS, Ute, FARRALL, Martin, WATKINS, Hugh, RICHARDS, A. Mark, CAMERON, Vicky A, MUENDLEIN, Axel, DREXEL, Heinz, QASIM, Atif, KOCH, Werner, EUY PARK, Jeong, KIMURA, Akinori, SHEN, Wei-Feng, SIMPSON, Lain A, HAZEN, Stanley L, HORNE, Benjamin D, HAUSER, Elizabeth R, QUYYUMI, Arshed A, REILLY, Muredach P, EPSTEIN, Stephen E, SAMANI, Nilesh J, SHU YE, BURNETT, Susan, VACCARINO, Viola L, MAZIAR ZAFARI, A, SHAH, Svati H

“…This study sought to ascertain the relationship of 9p21 locus with: 1) angiographic coronary artery disease (CAD) burden; and 2) myocardial infarction (MI) in…”
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Comment on: “A Promoter polymorphism (rs17222919, −1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population” by Hwan Kim D. et al. [Prostaglandins Leukot. Essent. Fatty Acids 85 (2011) 115–120] by Lapenna, Antonio, Laxton, Ross C, Ye, Shu

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Association of Matrix Metalloproteinase-8 Gene Variation with Breast Cancer Prognosis by DECOCK, Julie, LONG, Ji-Rong, WEI ZHENG, SHU YE, LAXTON, Ross C, SHU, Xiao-Ou, HODGKINSON, Conrad, HENDRICKX, Wouter, PEARCE, Eve G, GAO, Yu-Tang, PEREIRA, Andresa C, PARIDAENS, Robert

“…Animal and cell studies indicate an inhibitory effect of matrix metalloproteinase-8 (MMP8) on tumorigenesis and metastasis. We investigated whether MMP8 gene…”
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Association of Variation at the ABO Locus With Circulating Levels of Soluble Intercellular Adhesion Molecule-1, Soluble P-selectin, and Soluble E-selectin: A Meta-Analysis by Kiechl, Stefan, Paré, Guillaume, Barbalic, Maja, Qi, Lu, Dupuis, Josée, Dehghan, Abbas, Bis, Joshua C, Laxton, Ross C, Xiao, Qingzhong, Bonora, Enzo, Willeit, Johann, Xu, Qingbo, Witteman, Jacqueline C.M, Chasman, Daniel, Tracy, Russell P, Ballantyne, Christie M, Ridker, Paul M, Benjamin, Emelia J, Ye, Shu

“…BACKGROUND—Circulating levels of soluble intercellular adhesion molecule-1, soluble P-selectin, and soluble E-selectin have been associated with variation at…”
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Coronary Artery Disease-Related Genetic Variant on Chromosome 10q11 Is Associated With Carotid Intima-Media Thickness and Atherosclerosis by Kiechl, Stefan, Laxton, Ross C, Xiao, Qingzhong, Hernesniemi, Jussi A, Raitakari, Olli T, Kähönen, Mika, Mayosi, Bongani M, Jula, Antti, Moilanen, Leena, Willeit, Johann, Watkins, Hugh, Samani, Nilesh J, Lehtimäki, Terho J, Keavney, Bernard, Xu, Qingbo, Ye, Shu

“…OBJECTIVE—To investigate whether chromosome 10q11.21 influences common carotid intima-media thickness (IMT) and atherosclerosis and whether it is associated…”
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Primary glioblastoma with oligodendroglial differentiation has better clinical outcome but no difference in common biological markers compared with other types of glioblastoma by Laxton, Ross C, Popov, Sergey, Doey, Lawrence, Jury, Alexa, Bhangoo, Ranj, Gullan, Richard, Chandler, Chris, Brazil, Lucy, Sadler, Gill, Beaney, Ron, Sibtain, Naomi, King, Andrew, Bodi, Istvan, Jones, Chris, Ashkan, Keyoumars, Al-Sarraj, Safa

“…Glioblastoma multiforme with an oligodendroglial component (GBMO) has been recognized in the World Health Organization classification-however, the diagnostic…”
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ADAM33 expression in atherosclerotic lesions and relationship of ADAM33 gene variation with atherosclerosis by Holloway, John W, Laxton, Ross C, Rose-Zerilli, Matthew J, Holloway, Judith A, Andrews, A. Lynn, Riaz, Zeshan, Wilson, Susan J, Simpson, Iain A, Ye, Shu

“…Abstract A-disintegrin-and-metalloproteinase-domains (ADAMs) are membrane-anchored glycoproteins involved in cell adhesion, cell migration and proteolysis…”
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Association of MMP8 gene variation with an increased risk of malignant melanoma by Dębniak, Tadeusz, Jakubowska, Anna, Serrano-Fernández, Pablo, Kurzawski, Grzegorz, Cybulski, Cezary, Chauhan, Saleena Rani, Laxton, Ross C, Maleszka, Romuald, Lubinski, Jan, Ye, Shu

“…Matrix metalloproteinases (MMPs) are implicated in the development of cancers including malignant melanoma (MM) and breast cancer. We tested the possible…”
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Single nucleotide polymorphism on chromosome 9p21 and endothelial progenitor cells in a general population cohort by Ye, Shu, Willeit, Johann, Xiao, Qingzhong, Motterle, Anna, Laxton, Ross C, Oberhollenzer, Friedrich, Kiechl, Stefan, Xu, Qingbo

“…Abstract Objective Recent studies have revealed that sequence variation on chromosome 9p21 is a major genetic determinant for coronary heart disease and…”
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Association of Variation at the ABO Locus with Circulating Levels of sICAM-1, sP-selectin and sE-selectin: A Meta-Analysis by Kiechl, Stefan, Paré, Guillaume, Barbalic, Maja, Qi, Lu, Dupuis, Josée, Dehghan, Abbas, Bis, Joshua C., Laxton, Ross C., Xiao, Qingzhong, Bonora, Enzo, Willeit, Johann, Xu, Qingbo, Witteman, Jacqueline C.M., Chasman, Daniel, Tracy, Russell P., Ballantyne, Christie M., Ridker, Paul M., Benjamin, Emelia J., Ye, Shu

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