Search Results - "Lax, Pedro"

Dopaminergic Retinal Cell Loss and Visual Dysfunction in Parkinson Disease by Ortuño‐Lizarán, Isabel, Sánchez‐Sáez, Xavier, Lax, Pedro, Serrano, Geidy E., Beach, Thomas G., Adler, Charles H., Cuenca, Nicolás

“…Objective Considering the demonstrated implication of the retina in Parkinson disease (PD) pathology and the importance of dopaminergic cells in this tissue,…”
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Systemic inflammation induced by lipopolysaccharide aggravates inherited retinal dystrophy by Noailles, Agustina, Maneu, Victoria, Campello, Laura, Lax, Pedro, Cuenca, Nicolás

“…Retinal neurodegenerative diseases involve a scenario of inflammation and cell death that leads to morphological alterations and visual impairment. Non-ocular…”
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Interpretation of OCT and OCTA images from a histological approach: Clinical and experimental implications by Cuenca, Nicolás, Ortuño-Lizarán, Isabel, Sánchez-Sáez, Xavier, Kutsyr, Oksana, Albertos-Arranz, Henar, Fernández-Sánchez, Laura, Martínez-Gil, Natalia, Noailles, Agustina, López-Garrido, José Antonio, López-Gálvez, Maribel, Lax, Pedro, Maneu, Victoria, Pinilla, Isabel

“…Optical coherence tomography (OCT) and OCT angiography (OCTA) have been a technological breakthrough in the diagnosis, treatment, and follow-up of many retinal…”
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Astrocytes and Müller Cell Alterations During Retinal Degeneration in a Transgenic Rat Model of Retinitis Pigmentosa by Fernández-Sánchez, Laura, Lax, Pedro, Campello, Laura, Pinilla, Isabel, Cuenca, Nicolás

“…Retinitis pigmentosa includes a group of progressive retinal degenerative diseases that affect the structure and function of photoreceptors. Secondarily to the…”
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Microglia activation in a model of retinal degeneration and TUDCA neuroprotective effects by Noailles, Agustina, Fernández-Sánchez, Laura, Lax, Pedro, Cuenca, Nicolás

“…Retinitis pigmentosa is a heterogeneous group of inherited neurodegenerative retinal disorders characterized by a progressive peripheral vision loss and night…”
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Photosensitive Melanopsin-Containing Retinal Ganglion Cells in Health and Disease: Implications for Circadian Rhythms by Lax, Pedro, Ortuño-Lizarán, Isabel, Maneu, Victoria, Vidal-Sanz, Manuel, Cuenca, Nicolás

“…Melanopsin-containing retinal ganglion cells (mRGCs) represent a third class of retinal photoreceptors involved in regulating the pupillary light reflex and…”
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Neuroprotective effects of the cannabinoid agonist HU210 on retinal degeneration by Lax, Pedro, Esquiva, Gema, Altavilla, Cesare, Cuenca, Nicolás

“…Cannabinoids have been demonstrated to exert neuroprotective effects on different types of neuronal insults. Here we have addressed the therapeutic potential…”
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Gradual Increase in Environmental Light Intensity Induces Oxidative Stress and Inflammation and Accelerates Retinal Neurodegeneration by Kutsyr, Oksana, Sánchez-Sáez, Xavier, Martínez-Gil, Natalia, de Juan, Emilio, Lax, Pedro, Maneu, Victoria, Cuenca, Nicolás

“…Retinitis pigmentosa (RP) is a blinding neurodegenerative disease of the retina that can be affected by many factors. The present study aimed to analyze the…”
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Current and future therapeutic strategies for the treatment of retinal neurodegenerative diseases by Maneu, Victoria, Lax, Pedro, Cuenca, Nicolás

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Combined drug triads for synergic neuroprotection in retinal degeneration by Maneu, Victoria, Lax, Pedro, De Diego, Antonio Miguel G., Cuenca, Nicolás, García, Antonio G.

“…This review focuses on retina degeneration occurring during glaucoma, age-related macular degeneration (AMD), diabetic retinopathy (DR), and retinitis…”
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Persistent inflammatory state after photoreceptor loss in an animal model of retinal degeneration by Noailles, Agustina, Maneu, Victoria, Campello, Laura, Gómez-Vicente, Violeta, Lax, Pedro, Cuenca, Nicolás

“…Microglia act as the resident immune cells of the central nervous system, including the retina. In response to damaging stimuli microglia adopt an activated…”
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Retinitis pigmentosa is associated with shifts in the gut microbiome by Kutsyr, Oksana, Maestre-Carballa, Lucía, Lluesma-Gomez, Mónica, Martinez-Garcia, Manuel, Cuenca, Nicolás, Lax, Pedro

“…The gut microbiome is known to influence the pathogenesis and progression of neurodegenerative diseases. However, there has been relatively little focus upon…”
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Safranal, a saffron constituent, attenuates retinal degeneration in P23H rats by Fernández-Sánchez, Laura, Lax, Pedro, Esquiva, Gema, Martín-Nieto, José, Pinilla, Isabel, Cuenca, Nicolás

“…Saffron, an extract from Crocus sativus, has been largely used in traditional medicine for its antiapoptotic and anticarcinogenic properties. In this work, we…”
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Progesterone Attenuates Microglial-Driven Retinal Degeneration and Stimulates Protective Fractalkine-CX3CR1 Signaling by Roche, Sarah L, Wyse-Jackson, Alice C, Gómez-Vicente, Violeta, Lax, Pedro, Ruiz-Lopez, Ana M, Byrne, Ashleigh M, Cuenca, Nicolás, Cotter, Thomas G

“…Retinitis pigmentosa (RP) is a degenerative disease leading to photoreceptor cell loss. Mouse models of RP, such as the rd10 mouse (B6.CXBl-Pde6brd10/J), have…”
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Controlled delivery of tauroursodeoxycholic acid from biodegradable microspheres slows retinal degeneration and vision loss in P23H rats by Fernández-Sánchez, Laura, Bravo-Osuna, Irene, Lax, Pedro, Arranz-Romera, Alicia, Maneu, Victoria, Esteban-Pérez, Sergio, Pinilla, Isabel, Puebla-González, María Del Mar, Herrero-Vanrell, Rocío, Cuenca, Nicolás

“…Successful drug therapies for treating ocular diseases require effective concentrations of neuroprotective compounds maintained over time at the site of…”
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Ischemia-Reperfusion Increases TRPM7 Expression in Mouse Retinas by Martínez-Gil, Natalia, Kutsyr, Oksana, Fernández-Sánchez, Laura, Sánchez-Sáez, Xavier, Albertos-Arranz, Henar, Sánchez-Castillo, Carla, Vidal-Gil, Lorena, Cuenca, Nicolás, Lax, Pedro, Maneu, Victoria

“…Ischemia is the main cause of cell death in retinal diseases such as vascular occlusions, diabetic retinopathy, glaucoma, or retinopathy of prematurity…”
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Degeneration of human photosensitive retinal ganglion cells may explain sleep and circadian rhythms disorders in Parkinson's disease by Ortuño-Lizarán, Isabel, Esquiva, Gema, Beach, Thomas G, Serrano, Geidy E, Adler, Charles H, Lax, Pedro, Cuenca, Nicolás

“…Parkinson's disease (PD) patients often suffer from non-motor symptoms like sleep dysregulation, mood disturbances or circadian rhythms dysfunction. The…”
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Natural Compounds from Saffron and Bear Bile Prevent Vision Loss and Retinal Degeneration by Fernández-Sánchez, Laura, Lax, Pedro, Noailles, Agustina, Angulo, Antonia, Maneu, Victoria, Cuenca, Nicolás

“…All retinal disorders, regardless of their aetiology, involve the activation of oxidative stress and apoptosis pathways. The administration of neuroprotective…”
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Loss of Melanopsin-Expressing Ganglion Cell Subtypes and Dendritic Degeneration in the Aging Human Retina by Esquiva, Gema, Lax, Pedro, Pérez-Santonja, Juan J, García-Fernández, José M, Cuenca, Nicolás

“…In mammals, melanopsin-expressing retinal ganglion cells (mRGCs) are, among other things, involved in several non-image-forming visual functions, including…”
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Starburst amacrine cells, involved in visual motion perception, lose their synaptic input from dopaminergic amacrine cells and degenerate in Parkinson’s disease patients by Sánchez-Sáez, Xavier, Ortuño-Lizarán, Isabel, Sánchez-Castillo, Carla, Lax, Pedro, Cuenca, Nicolás

“…Abstract Background The main clinical symptoms characteristic of Parkinson’s disease (PD) are bradykinesia, tremor, and other motor deficits. However,…”
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