Search Results - "Lax, I."

Cellular signaling by fibroblast growth factor receptors by Eswarakumar, V.P., Lax, I., Schlessinger, J.

“…The 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different…”
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c-Abl antagonizes the YAP oncogenic function by Keshet, R, Adler, J, Ricardo Lax, I, Shanzer, M, Porat, Z, Reuven, N, Shaul, Y

“…YES-associated protein (YAP) is a central transcription coactivator that functions as an oncogene in a number of experimental systems. However, under DNA…”
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Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor by Yuzawa, Satoru, Opatowsky, Yarden, Zhang, Zhongtao, Mandiyan, Valsan, Lax, Irit, Schlessinger, Joseph

“…Stem Cell Factor (SCF) initiates its multiple cellular responses by binding to the ectodomain of KIT, resulting in tyrosine kinase activation. We describe the…”
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The polyomavirus middle T-antigen oncogene activates the Hippo pathway tumor suppressor Lats in a Src-dependent manner by Shanzer, M, Ricardo-Lax, I, Keshet, R, Reuven, N, Shaul, Y

“…The polyomavirus middle T antigen (PyMT) is an oncogene that activates the non-receptor tyrosine kinase, c-Src, and physically interacts with Taz (WWTR1). Taz…”
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SBRT of Large Tumors: A Retrospective Study by Grozman, V, Wersall, P, Lax, I, Lewensohn, R

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Critical Role for the Docking-Protein FRS2α in FGF Receptor-Mediated Signal Transduction Pathways by Hadari, Y R, Gotoh, N, Kouhara, H, Lax, I, Schlessinger, J

“…The docking protein FRS2α has been implicated as a mediator of signaling via fibroblast growth factor receptors (FGFRs). We have demonstrated that targeted…”
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Stimulation of Phosphatidylinositol 3-Kinase by Fibroblast Growth Factor Receptors is Mediated by Coordinated Recruitment of Multiple Docking Proteins by Ong, S. H., Hadari, Y. R., Gotoh, N., Guy, G. R., Schlessinger, J., Lax, I.

“…The docking protein FRS2 is a major downstream effector that links fibroblast growth factor (FGF) and nerve growth factor receptors with the…”
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HILUS-Retrospective—A Retrospective Toxicity Analysis of Patients Treated with SBRT for Centrally Located Lung Lesions by Lindberg, K., Karlsson, K., Grozman, V., Andersson, A., Lax, I., Wersäll, P., Lewensohn, R.

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Attenuation of Signaling Pathways Stimulated by Pathologically Activated FGF-Receptor 2 Mutants Prevents Craniosynostosis by Eswarakumar, V. P., Özcan, F., Lew, E. D., Bae, J. H., Tomé, F., Booth, C. J., Adams, D. J., Lax, I., Schlessinger, J.

“…Craniosynostosis, the fusion of one or more of the sutures of the skull vault before the brain completes its growth, is a common (1 in 2,500 births)…”
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Does Prostate Radiation Therapy Treatment Planning Benefit From MRI? by Onjukka, E, Rintelä, N, Castellanos, E, Djordjevic, M, Lax, I

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FRS2 Proteins Recruit Intracellular Signaling Pathways by Binding to Diverse Targets on Fibroblast Growth Factor and Nerve Growth Factor Receptors by Ong, S. H., Guy, G. R., Hadari, Y. R., Laks, S., Gotoh, N., Schlessinger, J., Lax, I.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Binding of Shp2 Tyrosine Phosphatase to FRS2 Is Essential for Fibroblast Growth Factor-Induced PC12 Cell Differentiation by Hadari, Y. R., Kouhara, H., Lax, I., Schlessinger, J.

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PO-0665: Radiation induced brachial plexus toxicity after SBRT of apically located lung lesions by Lindberg, K, Grozman, V, Lindberg, S, Lax, I, Lewensohn, R, Wersäll, P

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EP-1626: Predicting survival and tumour control probability for SBRT treatments - a comparison between the LQ and USC models by Lindblom, E, Lax, I, Dasu, A, Toma-Dasu, I

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Stereotactic body radiotherapy for medically inoperable patients with stage I non-small cell lung cancer – A first report of toxicity related to COPD/CVD in a non-randomized prospective phase II study by Baumann, Pia, Nyman, Jan, Hoyer, Morten, Gagliardi, Giovanna, Lax, Ingmar, Wennberg, Berit, Drugge, Ninni, Ekberg, Lars, Friesland, Signe, Johansson, Karl-Axel, Lund, Jo-Åsmund, Morhed, Elisabeth, Nilsson, Kristina, Levin, Nina, Paludan, Merete, Sederholm, Christer, Traberg, Anders, Wittgren, Lena, Lewensohn, Rolf

“…Abstract Background and Aims In a retrospective study using stereotactic body radiotherapy (SBRT) in medically inoperable patients with stage I NSCLC we…”
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A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway by Kouhara, H, Hadari, Y.R, Spivak-Kroizman, T, Schilling, J, Bar-Sagi, D, Lax, I, Schlessinger, J

“…Activation of the Ras/MAPK signaling cascade is essential for growth factor–induced cell proliferation and differentiation. In this report, we describe the…”
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Outcome After SBRT of Adrenal Gland Metastases: A Multicenter Retrospective Analysis of 60 Adrenal Metastases by Lindberg, K, Grozman, V, Haasbeek, C, Westman, G, Lax, I, Wersäll, P, Andersson, A, Lewensohn, R

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Essential Role of Shp2-Binding Sites on FRS2α for Corticogenesis and for FGF2-Dependent Proliferation of Neural Progenitor Cells by Yamamoto, S., Yoshino, I., T. Shimazaki, M. Murohashi, R. F. Hevner, Lax, I., Okano, H., Shibuya, M., Schlessinger, J., Gotoh, N.

“…Mammalian corticogenesis occurs through a complex process that includes neurogenesis, in which neural progenitor cells proliferate, differentiate, and migrate…”
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Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation by Spivak-Kroizman, T, Lemmon, M A, Dikic, I, Ladbury, J E, Pinchasi, D, Huang, J, Jaye, M, Crumley, G, Schlessinger, J, Lax, I

“…Heparin is required for fibroblast growth factor (FGF) stimulation of biological responses. Using isothermal titration calorimetry, we show that acidic FGF…”
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OC-0565: SPACE - A randomized study of SBRT vs conventional fractionated radiotherapy in medically inoperable stage I NSCLC by Nyman, J, Hallqvist, A, Lund, J.A, Brustugun, O.T, Bergström, P, Friesland, S, Lewensohn, R, Drugge, N, Rylander, H, Lax, I

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