Search Results - "Lawson, D"

Rho GTPase signaling complexes in cell migration and invasion by Lawson, Campbell D, Ridley, Anne J

“…Cell migration is dependent on the dynamic formation and disassembly of actin filament-based structures, including lamellipodia, filopodia, invadopodia, and…”
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Metal–Organic Frameworks for Drug Delivery: A Design Perspective by Lawson, Harrison D, Walton, S. Patrick, Chan, Christina

“…The use of metal–organic frameworks (MOFs) in biomedical applications has greatly expanded over the past decade due to the precision tunability, high surface…”
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The economic burden of physical inactivity: a global analysis of major non-communicable diseases by Ding, Ding, Dr, Lawson, Kenny D, PhD, Kolbe-Alexander, Tracy L, PhD, Finkelstein, Eric A, Prof, Katzmarzyk, Peter T, Prof, van Mechelen, Willem, Prof, Pratt, Michael, Prof

“…Summary Background The pandemic of physical inactivity is associated with a range of chronic diseases and early deaths. Despite the well documented disease…”
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Rings in Clinical Trials and Drugs: Present and Future by Shearer, Jonathan, Castro, Jose L., Lawson, Alastair D. G., MacCoss, Malcolm, Taylor, Richard D.

“…We present a comprehensive analysis of all ring systems (both heterocyclic and nonheterocyclic) in clinical trial compounds and FDA-approved drugs. We show 67%…”
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Allicin Bioavailability and Bioequivalence from Garlic Supplements and Garlic Foods by Lawson, Larry D, Hunsaker, Scott M

“…Allicin is considered responsible for most of the pharmacological activity of crushed raw garlic cloves. However, when garlic supplements and garlic foods are…”
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The on-off relationship of Rho and Rac during integrin-mediated adhesion and cell migration by Lawson, Campbell D, Burridge, Keith

“…Rho GTPases play an essential role in regulating cell spreading, adhesion, and migration downstream of integrin engagement with the extracellular matrix. In…”
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Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish by Kok, Fatma O., Shin, Masahiro, Ni, Chih-Wen, Gupta, Ankit, Grosse, Ann S., van Impel, Andreas, Kirchmaier, Bettina C., Peterson-Maduro, Josi, Kourkoulis, George, Male, Ira, DeSantis, Dana F., Sheppard-Tindell, Sarah, Ebarasi, Lwaki, Betsholtz, Christer, Schulte-Merker, Stefan, Wolfe, Scot A., Lawson, Nathan D.

“…The widespread availability of programmable site-specific nucleases now enables targeted gene disruption in the zebrafish. In this study, we applied…”
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Importance of Rigidity in Designing Small Molecule Drugs To Tackle Protein-Protein Interactions (PPIs) through Stabilization of Desired Conformers by Lawson, Alastair D G, MacCoss, Malcolm, Heer, Jag P

“…Tackling PPIs, particularly by stabilizing clinically favored conformations of target proteins, with orally available, bona fide small molecules remains a…”
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Forward and Reverse Genetic Approaches for the Analysis of Vertebrate Development in the Zebrafish by Lawson, Nathan D., Wolfe, Scot A.

“…The development of facile forward and reverse genetic approaches has propelled the deconvolution of gene function in biology. While the origins of these…”
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ChIPpeakAnno: a Bioconductor package to annotate ChIP-seq and ChIP-chip data by Zhu, Lihua J, Gazin, Claude, Lawson, Nathan D, Pagès, Hervé, Lin, Simon M, Lapointe, David S, Green, Michael R

“…Chromatin immunoprecipitation (ChIP) followed by high-throughput sequencing (ChIP-seq) or ChIP followed by genome tiling array analysis (ChIP-chip) have become…”
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The economic burden of physical inactivity: a systematic review and critical appraisal by Ding, Ding, Kolbe-Alexander, Tracy, Nguyen, Binh, Katzmarzyk, Peter T, Pratt, Michael, Lawson, Kenny D

“…To summarise the literature on the economic burden of physical inactivity in populations, with emphases on appraising the methodologies and providing…”
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ATACseqQC: a Bioconductor package for post-alignment quality assessment of ATAC-seq data by Ou, Jianhong, Liu, Haibo, Yu, Jun, Kelliher, Michelle A, Castilla, Lucio H, Lawson, Nathan D, Zhu, Lihua Julie

“…ATAC-seq (Assays for Transposase-Accessible Chromatin using sequencing) is a recently developed technique for genome-wide analysis of chromatin accessibility…”
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Guidelines for morpholino use in zebrafish by Stainier, Didier Y R, Raz, Erez, Lawson, Nathan D, Ekker, Stephen C, Burdine, Rebecca D, Eisen, Judith S, Ingham, Philip W, Schulte-Merker, Stefan, Yelon, Deborah, Weinstein, Brant M, Mullins, Mary C, Wilson, Stephen W, Ramakrishnan, Lalita, Amacher, Sharon L, Neuhauss, Stephan C F, Meng, Anming, Mochizuki, Naoki, Panula, Pertti, Moens, Cecilia B

“…About the Authors: Didier Y. R. Stainier * E-mail: didier.stainier@mpi-bn.mpg.de (DYRS); cmoens@fredhutch.org (CBM) Affiliation: Department of Developmental…”
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A survey of stereotactic body radiotherapy use in the United States by Pan, Hubert, Simpson, Daniel R., Mell, Loren K., Mundt, Arno J., Lawson, Joshua D.

“…BACKGROUND: Stereotactic body radiotherapy (SBRT) is a technique used to deliver high, ablative doses of radiation in a limited number of fractions to ≥1…”
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Genomic Characterization of Endothelial Enhancers Reveals a Multifunctional Role for NR2F2 in Regulation of Arteriovenous Gene Expression by Sissaoui, Samir, Yu, Jun, Yan, Aimin, Li, Rui, Yukselen, Onur, Kucukural, Alper, Zhu, Lihua Julie, Lawson, Nathan D.

“…Significant progress has revealed transcriptional inputs that underlie regulation of artery and vein endothelial cell fates. However, little is known…”
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A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity by Cifuentes, Daniel, Xue, Huiling, Taylor, David W., Patnode, Heather, Mishima, Yuichiro, Cheloufi, Sihem, Ma, Enbo, Mane, Shrikant, Hannon, Gregory J., Lawson, Nathan D., Wolfe, Scot A., Giraldez, Antonio J.

“…Dicer is a central enzyme in microRNA (miRNA) processing. We identified a Dicer-independent miRNA biogenesis pathway that uses Argonaute2 (Ago2) slicer…”
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miR-221 Is Required for Endothelial Tip Cell Behaviors during Vascular Development by Nicoli, Stefania, Knyphausen, Carl-Philipp, Zhu, Lihua J., Lakshmanan, Abirami, Lawson, Nathan D.

“…Angiogenesis requires coordination of distinct cell behaviors between tip and stalk cells. Although this process is governed by regulatory interactions between…”
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Back and forth: History of and new insights on the vertebrate lymphatic valve by Shin, Masahiro, Lawson, Nathan D.

“…Lymphatic valves develop from pre‐existing endothelial cells through a step‐wise process involving complex changes in cell shape and orientation, along with…”
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Reducing the inherent auto-inhibitory interaction within the pegRNA enhances prime editing efficiency by Ponnienselvan, Karthikeyan, Liu, Pengpeng, Nyalile, Thomas, Oikemus, Sarah, Maitland, Stacy A, Lawson, Nathan D, Luban, Jeremy, Wolfe, Scot A

“…Abstract Prime editing systems have enabled the incorporation of precise edits within a genome without introducing double strand breaks. Previous studies…”
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Integrated molecular analysis identifies a conserved pericyte gene signature in zebrafish by Shih, Yu-Huan, Portman, Daneal, Idrizi, Feston, Grosse, Ann, Lawson, Nathan D

“…Pericytes reside in capillary beds where they share a basement membrane with endothelial cells and regulate their function. However, little is known about…”
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