Search Results - "Laws, S. C."

Estrogenic Activity of Octylphenol, Nonylphenol, Bisphenol A and Methoxychlor in Rats by Laws, Susan C., Carey, Stephan A., Ferrell, Janet M., Bodman, Gerald J., Cooper, Ralph L.

“…Considerable attention has recently been focused on environmental chemicals that disrupt the reproductive system by altering steroid receptor function…”
Get full text

The effect of atrazine on puberty in male Wistar rats : An evaluation in the protocol for the assessment of pubertal development and thyroid function by STOKER, T. E, LAWS, S. C, GUIDICI, D. L, COOPER, R. L

“…Since atrazine (ATR), a chlorotriazine herbicide, has been shown previously to alter the secretion of luteinizing hormone (LH) and prolactin (PRL) through a…”
Get full text

The Effects of Atrazine Metabolites on Puberty and Thyroid Function in the Male Wistar Rat by Stoker, T. E., Guidici, D. L., Laws, S. C., Cooper, R. L.

“…Recently we reported that atrazine (ATR), a chlorotriazine herbicide, alters the onset of puberty in male Wistar rats. In this study, we examined the same…”
Get full text

The effects of atrazine on female Wistar rats : An evaluation of the protocol for assessing pubertal development and thyroid function by LAWS, Susan C, FERRELL, Janet M, STOKER, Tammy E, SCHMID, Judith, COOPER, Ralph L

“…The effects of atrazine (ATR), a chlorotriazine herbicide, on the onset of puberty were evaluated in Wistar rats. Female rats were dosed by oral gavage from…”
Get full text

Persistent DDT metabolite p,p'-DDE is a potent androgen receptor antagonist by Kelce, William R, Stone, Christy R, Laws, Susan C, Gray, L. Earl, Kemppainen, Jon A, Wilson, Elizabeth M

“…The increase in the number of reports of abnormalities in male sex development in wildlife and humans coincided with the introduction of 'oestrogenic'…”
Get full text

Evaluation of ammonium perchlorate in the endocrine disruptor screening and testing program's male pubertal protocol: Ability to detect effects on thyroid endpoints by Stoker, T.E., Ferrell, J.M., Laws, S.C., Cooper, R.L., Buckalew, A.

“…The U.S. EPA Endocrine Disruptor Screening Program (EDSP) Tier 1 male pubertal protocol was designed as a screen to detect endocrine-disrupting chemicals which…”
Get full text

Xenoendocrine disrupters-tiered screening and testing: Filling key data gaps by Gray, L.E., Ostby, J., Wilson, V., Lambright, C., Bobseine, K., Hartig, P., Hotchkiss, A., Wolf, C., Furr, J., Price, M., Parks, L., Cooper, R.L., Stoker, T.E., Laws, S.C., Degitz, S.J., Jensen, K.M., Kahl, M.D., Korte, J.J., Makynen, E.A., Tietge, J.E., Ankley, G.T.

“…The US Environmental Protection Agency (EPA) is developing a screening and testing program for endocrine disrupting chemicals (EDCs) to detect alterations of…”
Get full text

Use of the laboratory rat as a model in endocrine disruptor screening and testing by Gray, L.E. Jr, Wilson, V, Noriega, N, Lambright, C, Furr, J, Stoker, T.E, Laws, S.C, Goldman, J, Cooper, R.L, Foster, P.M.D

“…The screening and testing program the US Environmental Protection Agency (EPA) is currently developing to detect endocrine-disrupting chemicals (EDCs) is…”
Get full text

Pubertal Development in Female Wistar Rats following Exposure to Propazine and Atrazine Biotransformation By-Products, Diamino-S-Chlorotriazine and Hydroxyatrazine by Laws, Susan C., Ferrell, Janet M., Stoker, Tammy E., Cooper, Ralph L.

“…We showed previously that the chlorotriazine herbicide, atrazine (ATR), delays the onset of pubertal development in female rats. ATR and its biotransformation…”
Get full text

Environmental hormone disruptors: evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolites by Kelce, W R, Monosson, E, Gamcsik, M P, Laws, S C, Gray, Jr, L E

“…Recent studies with vinclozolin, a dicarboximide fungicide, demonstrate that perinatal exposure to 100 mg vinclozolin/kg/day from Gestational Day 14 through…”
Get more information

Endocrine-Disrupting Chemicals: Prepubertal Exposures and Effects on Sexual Maturation and Thyroid Activity in the Female Rat. A Focus on the EDSTAC Recommendations by Goldman, Jerome M., Laws, Susan C., Balchak, Sharon K., Cooper, Ralph L., Kavlock, Robert J.

“…In 1996, the US Environmental Protection Agency was given a mandate by Congress to develop a screening program that would evaluate whether variously identified…”
Get full text

Prepubertal Exposure to Compounds That Increase Prolactin Secretion in the Male Rat: Effects on the Adult Prostate by STOKER, T. E, ROBINETTE, C. L, BRITT, B. H, LAWS, S. C, COOPER, R. L

“…To test the hypothesis that a transient increase in prolactin (PRL) secretion prior to puberty can result in an alteration of the adult prostate, male rats…”
Get full text

Assessment of estrogenicity by using the delayed implanting rat model and examples by Cummings, Audrey M., Laws, Susan C.

“…Endocrine disrupting chemicals have recently drawn increased interest. The delayed implanting rat model is a method that can identify and quantify the…”
Get full text

Methoxychlor mimics the action of 17β-estradiol on induction of uterine epidermal growth factor receptors in immature female rats by Metcalf, J.L., Laws, S.C., Cummings, A.M.

“…Epidermal growth factor (EGF) and its receptor (EGF-R) have been implicated as mediators for estrogen induced cellular growth. This study examines whether the…”
Get full text

Inhibin increases and progesterone decreases receptors for gonadotropin-releasing hormone in ovine pituitary culture by Laws, S C, Beggs, M J, Webster, J C, Miller, W L

“…Treatments (48 h) with highly purified bovine or porcine inhibins (10 ng/ml) induced ovine pituitary cells to increase their binding for…”
Get more information

Vinclozolin does not alter progesterone receptor (PR) function in vivo despite inhibition of PR binding by its metabolites in vitro by Laws, Susan C., Carey, Stephan A., Kelce, William R., Cooper, Ralph L., Gray, L.Earl

“…Vinclozolin, a dicarboximide fungicide, alters morphological sex differentiation in male rats following perinatal exposure. The occurrence of these…”
Get full text

Hormonal regulation of gonadotropin-releasing hormone receptors and messenger RNA activity in ovine pituitary culture by Sealfon, S C, Laws, S C, Wu, J C, Gillo, B, Miller, W L

“…Previous studies demonstrate that gonadotroph responsiveness to GnRH, GnRH binding, and the apparent number of GnRH receptors are all increased by 17…”
Get more information

Lindane does not alter the estrogen receptor or the estrogen-dependent induction of progesterone receptors in sexually immature or ovariectomized adult rats by Laws, S C, Carey, S A, Hart, D W, Cooper, R L

“…Lindane, gamma-1,2,3,4,5,6-hexachlorocyclohexane (gamma-HCH), has been shown to disrupt reproductive function in mammals. Many of these adverse effects on…”
Get more information

Ligand-Based Identification of Environmental Estrogens by Waller, Chris L, Oprea, Tudor I, Chae, Kun, Park, Hee-Kyoung, Korach, Kenneth S, Laws, Susan C, Wiese, Thomas E, Kelce, William R, Gray, L. Earl

“…Comparative molecular field analysis (CoMFA), a three-dimensional quantitative structure−activity relationship (3D-QSAR) paradigm, was used to examine the…”
Get full text

Chlordimeform-induced alterations in endocrine regulation within the male rat reproductive system by Goldman, J M, Cooper, R L, Laws, S C, Rehnberg, G L, Edwards, T L, McElroy, W K, Hein, J F

“…The acaricide chlordimeform has been reported to have adverse effects in mammals that may be mediated by an interaction with alpha-adrenergic receptors. Since…”
Get more information