Search Results - "Laws, Mary J."
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Gap junction communication between uterine stromal cells plays a critical role in pregnancy-associated neovascularization and embryo survival
Published in Development (Cambridge) (01-08-2008)“…In the uterus, the formation of new maternal blood vessels in the stromal compartment at the time of embryonic implantation is critical for the establishment…”
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Imidacloprid and Its Bioactive Metabolite, Desnitro-Imidacloprid, Differentially Affect Ovarian Antral Follicle Growth, Morphology, and Hormone Synthesis In Vitro
Published in Toxics (Basel) (01-04-2023)“…Imidacloprid is a neonicotinoid pesticide used in large-scale agricultural systems, home gardens, and veterinary pharmaceuticals. Imidacloprid is a small…”
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Effects of Phthalate Mixtures on Ovarian Folliculogenesis and Steroidogenesis
Published in Toxics (Basel) (16-05-2022)“…The female reproductive system is dependent upon the health of the ovaries. The ovaries are responsible for regulating reproduction and endocrine function…”
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Rac1 Regulates Endometrial Secretory Function to Control Placental Development
Published in PLoS genetics (01-08-2015)“…During placenta development, a succession of complex molecular and cellular interactions between the maternal endometrium and the developing embryo ensures…”
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Correction: Fletcher et al. Effects of Phthalate Mixtures on Ovarian Folliculogenesis and Steroidogenesis. Toxics 2022, 10 , 251
Published in Toxics (Basel) (26-09-2022)“…The authors wish to make the following corrections to this paper [...]…”
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Dysregulated estrogen receptor signaling in the hypothalamic-pituitary-ovarian axis leads to ovarian epithelial tumorigenesis in mice
Published in PLoS genetics (01-03-2014)“…The etiology of ovarian epithelial cancer is poorly understood, mainly due to the lack of an appropriate experimental model for studying the onset and…”
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Isolation of DiNP-Degrading Microbes from the Mouse Colon and the Influence DiNP Exposure Has on the Microbiota, Intestinal Integrity, and Immune Status of the Colon
Published in Toxics (Basel) (06-02-2022)“…Di-isononyl phthalate (DiNP) is a plasticizer used to impart flexibility or stability in a variety of products including polyvinyl chloride, cable coatings,…”
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Neonicotinoids differentially modulate nicotinic acetylcholine receptors in immature and antral follicles in the mouse ovary
Published in Biology of reproduction (15-08-2024)“…Abstract Neonicotinoids are the most widely used insecticides in the world. They are synthetic nicotine derivatives that act as nicotinic acetylcholine…”
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Long-term exposure to di(2-ethylhexyl) phthalate, diisononyl phthalate, and a mixture of phthalates alters estrous cyclicity and/or impairs gestational index and birth rate in mice
Published in Toxicological sciences (12-05-2023)“…Abstract Phthalates are found in plastic food containers, medical plastics, and personal care products. However, the effects of long-term phthalate exposure on…”
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The role of the aryl hydrocarbon receptor in mediating the effects of mono(2-ethylhexyl) phthalate in mouse ovarian antral follicles
Published in Biology of reproduction (13-03-2024)“…Di(2-ethylhexyl) phthalate (DEHP) is a pervasive environmental toxicant used in the manufacturing of numerous consumer products, medical supplies, and building…”
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A hypoxia-induced Rab pathway regulates embryo implantation by controlled trafficking of secretory granules
Published in Proceedings of the National Academy of Sciences - PNAS (23-06-2020)“…Implantation is initiated when an embryo attaches to the uterine luminal epithelium and subsequently penetrates into the underlying stroma to firmly embed in…”
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Chronic exposure to a mixture of phthalates shifts the white and brown adipose tissue phenotypes in female mice
Published in Toxicological sciences (31-05-2023)“…Abstract Phthalates are endocrine-disrupting chemicals used in consumer products. Although phthalates are obesogens and affect metabolic function, it is…”
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Structurally Novel Antiestrogens Elicit Differential Responses from Constitutively Active Mutant Estrogen Receptors in Breast Cancer Cells and Tumors
Published in Cancer research (Chicago, Ill.) (15-10-2017)“…Many estrogen receptor α (ERα)-positive breast cancers develop resistance to endocrine therapy via mutation of ERs whose constitutive activation is associated…”
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Ovarian antral follicles metabolize imidacloprid in vitro
Published in Toxicological sciences (28-11-2023)“…Abstract Neonicotinoid insecticides are synthetic nicotine derivatives that have high affinity for invertebrate nicotine receptors and low affinity for…”
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The effects of short-term and long-term phthalate exposures on ovarian follicle growth dynamics and hormone levels in female mice
Published in Biology of reproduction (13-01-2024)“…Di(2-ethylhexyl) phthalate and diisononyl phthalate are widely used as plasticizers in polyvinyl chloride products. Short-term exposures to phthalates affect…”
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Phthalate monoesters act through peroxisome proliferator-activated receptors in the mouse ovary
Published in Reproductive toxicology (Elmsford, N.Y.) (01-06-2022)“…Widespread use of phthalates as solvents and plasticizers leads to everyday human exposure. The mechanisms by which phthalate metabolites act as ovarian…”
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Chronic exposure of mice to phthalates enhances TGF beta signaling and promotes uterine fibrosis
Published in Reproductive toxicology (Elmsford, N.Y.) (01-12-2023)“…Phthalates are synthetic chemicals widely used as plasticizers and stabilizers in various consumer products. Because of the extensive production and use of…”
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Dietary exposure to an environmentally relevant phthalate mixture alters follicle dynamics, hormone levels, ovarian gene expression, and pituitary gene expression in female mice
Published in Reproductive toxicology (Elmsford, N.Y.) (01-12-2023)“…Phthalates are chemicals ubiquitously used in industry. Individual phthalates have been found to adversely affect female reproduction; however, humans are…”
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Prenatal and postnatal exposure to polychlorinated biphenyls alter follicle numbers, gene expression, and a proliferation marker in the rat ovary
Published in Reproductive toxicology (Elmsford, N.Y.) (01-09-2023)“…Polychlorinated biphenyls (PCBs) were used in industrial applications until they were banned in the 1970s, but they still persist in the environment. Little is…”
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The Effects of Environmental Contaminant Exposure on Reproductive Aging and the Menopause Transition
Published in Current environmental health reports (01-03-2022)“…Purpose of Review Menopause marks the end of a woman’s reproductive lifetime. On average, natural menopause occurs at 51 years of age. However, some women…”
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