Electrical Detection of Amine Ligation to a Metalloporphyrin via a Hybrid SOI-MOSFET

A close-packed monolayer of zinc 5,10,15,20-tetrakis(3-carboxyphenyl)porphyrin has been prepared and deposited on the thin native oxide covering the surface of an SOI-MOSFET (silicon-on-insulator metal-oxide-semiconductor field effect transistor) using Langmuir−Blodgett techniques. When the device i...

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Bibliographic Details
Published in:	Journal of the American Chemical Society Vol. 130; no. 7; pp. 2226 - 2233
Main Authors:	Takulapalli, Bharath R, Laws, Gez M, Liddell, Paul A, Andréasson, Joakim, Erno, Zach, Gust, Devens, Thornton, Trevor J
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 20-02-2008
Subjects:	Amines - chemistry Electrochemistry Hydrogen-Ion Concentration Kinetics Light Metalloporphyrins - chemistry Models, Molecular Oxides - chemistry Piperidines - chemistry Pyridines - chemistry Semiconductors Silicon - chemistry Volatilization Zinc - chemistry
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Summary:	A close-packed monolayer of zinc 5,10,15,20-tetrakis(3-carboxyphenyl)porphyrin has been prepared and deposited on the thin native oxide covering the surface of an SOI-MOSFET (silicon-on-insulator metal-oxide-semiconductor field effect transistor) using Langmuir−Blodgett techniques. When the device is exposed to amine vapors in a nitrogen atmosphere, the amine coordinates to the zinc atom. The resulting change in electron distribution within the porphyrin leads to a large change in the drain current of the transistor, biased via a back gate. This change is sensitive to both the amount of amine present and the base strength of the amine. Only very small changes in drain current were observed with a monolayer of free base porphyrin or palmitic acid. After exposure to high pyridine concentrations, the device response saturates, but partially recovers after overnight exposure to flowing nitrogen gas. Interestingly, the device response is instantaneously reset by exposure to visible light, suggesting that photode-ligation occurs. An electrical model for the hybrid device that describes its response to ligand binding in terms of a change in the work function of the porphyrin monolayer has been developed. A transistor response to a few hundred attomoles of bound pyridine can be readily detected. This extreme sensitivity, coupled with the ability to reset the device using light, suggests that such systems might be useful as sensors.
Bibliography:	ark:/67375/TPS-WP9RVJ96-2 istex:F366BA1D3D44C4732F17C9CBC6C11D45A046329C ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0002-7863 1520-5126 1520-5126
DOI:	10.1021/ja076328a