Search Results - "Lawrie, Alison M"

Alternate aerosol and systemic immunisation with a recombinant viral vector for tuberculosis, MVA85A: A phase I randomised controlled trial by Manjaly Thomas, Zita-Rose, Satti, Iman, Marshall, Julia L, Harris, Stephanie A, Lopez Ramon, Raquel, Hamidi, Ali, Minhinnick, Alice, Riste, Michael, Stockdale, Lisa, Lawrie, Alison M, Vermaak, Samantha, Wilkie, Morven, Bettinson, Henry, McShane, Helen

“…There is an urgent need for an effective tuberculosis (TB) vaccine. Heterologous prime-boost regimens induce potent cellular immunity. MVA85A is a candidate TB…”
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Phase Ia clinical evaluation of the safety and immunogenicity of the Plasmodium falciparum blood-stage antigen AMA1 in ChAd63 and MVA vaccine vectors by Sheehy, Susanne H, Duncan, Christopher J A, Elias, Sean C, Biswas, Sumi, Collins, Katharine A, O'Hara, Geraldine A, Halstead, Fenella D, Ewer, Katie J, Mahungu, Tabitha, Spencer, Alexandra J, Miura, Kazutoyo, Poulton, Ian D, Dicks, Matthew D J, Edwards, Nick J, Berrie, Eleanor, Moyle, Sarah, Colloca, Stefano, Cortese, Riccardo, Gantlett, Katherine, Long, Carole A, Lawrie, Alison M, Gilbert, Sarah C, Doherty, Tom, Nicosia, Alfredo, Hill, Adrian V S, Draper, Simon J

“…Traditionally, vaccine development against the blood-stage of Plasmodium falciparum infection has focused on recombinant protein-adjuvant formulations in order…”
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Prime and target immunization protects against liver-stage malaria in mice by Gola, Anita, Silman, Daniel, Walters, Adam A, Sridhar, Saranya, Uderhardt, Stefan, Salman, Ahmed M, Halbroth, Benedict R, Bellamy, Duncan, Bowyer, Georgina, Powlson, Jonathan, Baker, Megan, Venkatraman, Navin, Poulton, Ian, Berrie, Eleanor, Roberts, Rachel, Lawrie, Alison M, Angus, Brian, Khan, Shahid M, Janse, Chris J, Ewer, Katie J, Germain, Ronald N, Spencer, Alexandra J, Hill, Adrian V S

“…Despite recent advances in treatment and vector control, malaria is still a leading cause of death, emphasizing the need for an effective vaccine. The malaria…”
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Reduced blood-stage malaria growth and immune correlates in humans following RH5 vaccination by Minassian, Angela M, Silk, Sarah E, Barrett, Jordan R, Nielsen, Carolyn M, Miura, Kazutoyo, Diouf, Ababacar, Loos, Carolin, Fallon, Jonathan K, Michell, Ashlin R, White, Michael T, Edwards, Nick J, Poulton, Ian D, Mitton, Celia H, Payne, Ruth O, Marks, Michael, Maxwell-Scott, Hector, Querol-Rubiera, Antonio, Bisnauthsing, Karen, Batra, Rahul, Ogrina, Tatiana, Brendish, Nathan J, Themistocleous, Yrene, Rawlinson, Thomas A, Ellis, Katherine J, Quinkert, Doris, Baker, Megan, Lopez Ramon, Raquel, Ramos Lopez, Fernando, Barfod, Lea, Folegatti, Pedro M, Silman, Daniel, Datoo, Mehreen, Taylor, Iona J, Jin, Jing, Pulido, David, Douglas, Alexander D, de Jongh, Willem A, Smith, Robert, Berrie, Eleanor, Noe, Amy R, Diggs, Carter L, Soisson, Lorraine A, Ashfield, Rebecca, Faust, Saul N, Goodman, Anna L, Lawrie, Alison M, Nugent, Fay L, Alter, Galit, Long, Carole A, Draper, Simon J

“…Development of an effective vaccine against the pathogenic blood-stage infection of human malaria has proved challenging, and no candidate vaccine has affected…”
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Safety, Immunogenicity and Efficacy of Prime-Boost Vaccination with ChAd63 and MVA Encoding ME-TRAP against Plasmodium falciparum Infection in Adults in Senegal by Mensah, Victorine A, Gueye, Aly, Ndiaye, Magatte, Edwards, Nick J, Wright, Danny, Anagnostou, Nicholas A, Syll, Massamba, Ndaw, Amy, Abiola, Annie, Bliss, Carly, Gomis, Jules-François, Petersen, Ines, Ogwang, Caroline, Dieye, Tandakha, Viebig, Nicola K, Lawrie, Alison M, Roberts, Rachel, Nicosia, Alfredo, Faye, Babacar, Gaye, Oumar, Leroy, Odile, Imoukhuede, Egeruan B, Ewer, Katie J, Bejon, Philip, Hill, Adrian V S, Cisse, Badara

“…Malaria transmission is in decline in some parts of Africa, partly due to the scaling up of control measures. If the goal of elimination is to be achieved,…”
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A phase Ia study to assess the safety and immunogenicity of new malaria vaccine candidates ChAd63 CS administered alone and with MVA CS by de Barra, Eoghan, Hodgson, Susanne H, Ewer, Katie J, Bliss, Carly M, Hennigan, Kerrie, Collins, Ann, Berrie, Eleanor, Lawrie, Alison M, Gilbert, Sarah C, Nicosia, Alfredo, McConkey, Samuel J, Hill, Adrian V S

“…Plasmodium falciparum (P. falciparum) malaria remains a significant cause of mortality and morbidity throughout the world. Development of an effective vaccine…”
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Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1/Alhydrogel+CPG 7909 by Duncan, Christopher J A, Sheehy, Susanne H, Ewer, Katie J, Douglas, Alexander D, Collins, Katharine A, Halstead, Fenella D, Elias, Sean C, Lillie, Patrick J, Rausch, Kelly, Aebig, Joan, Miura, Kazutoyo, Edwards, Nick J, Poulton, Ian D, Hunt-Cooke, Angela, Porter, David W, Thompson, Fiona M, Rowland, Ros, Draper, Simon J, Gilbert, Sarah C, Fay, Michael P, Long, Carole A, Zhu, Daming, Wu, Yimin, Martin, Laura B, Anderson, Charles F, Lawrie, Alison M, Hill, Adrian V S, Ellis, Ruth D

“…Inhibition of parasite growth is a major objective of blood-stage malaria vaccines. The in vitro assay of parasite growth inhibitory activity (GIA) is widely…”
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Safety and Immunogenicity of ChAd63/MVA Pfs25-IMX313 in a Phase I First-in-Human Trial by de Graaf, Hans, Payne, Ruth O, Taylor, Iona, Miura, Kazutoyo, Long, Carol A, Elias, Sean C, Zaric, Marija, Minassian, Angela M, Silk, Sarah E, Li, Lee, Poulton, Ian D, Baker, Megan, Draper, Simon J, Gbesemete, Diane, Brendish, Nathan J, Martins, Filipa, Marini, Arianna, Mekhaiel, David, Edwards, Nick J, Roberts, Rachel, Vekemans, Johan, Moyle, Sarah, Faust, Saul N, Berrie, Eleanor, Lawrie, Alison M, Hill, Fergal, Hill, Adrian V S, Biswas, Sumi

“…Transmission blocking vaccines targeting the sexual-stages of the malaria parasite could play a major role to achieve elimination and eradication of malaria…”
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Optimising Controlled Human Malaria Infection Studies Using Cryopreserved P. falciparum Parasites Administered by Needle and Syringe by Sheehy, Susanne H, Spencer, Alexandra J, Douglas, Alexander D, Sim, B Kim Lee, Longley, Rhea J, Edwards, Nick J, Poulton, Ian D, Kimani, Domtila, Williams, Andrew R, Anagnostou, Nicholas A, Roberts, Rachel, Kerridge, Simon, Voysey, Merryn, James, Eric R, Billingsley, Peter F, Gunasekera, Anusha, Lawrie, Alison M, Hoffman, Stephen L, Hill, Adrian V S

“…Controlled human malaria infection (CHMI) studies have become a routine tool to evaluate efficacy of candidate anti-malarial drugs and vaccines. To date, CHMI…”
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Combining Viral Vectored and Protein-in-adjuvant Vaccines Against the Blood-stage Malaria Antigen AMA1: Report on a Phase 1a Clinical Trial by Hodgson, Susanne H, Choudhary, Prateek, Elias, Sean C, Milne, Kathryn H, Rampling, Thomas W, Biswas, Sumi, Poulton, Ian D, Miura, Kazutoyo, Douglas, Alexander D, Alanine, Daniel GW, Illingworth, Joseph J, de Cassan, Simone C, Zhu, Daming, Nicosia, Alfredo, Long, Carole A, Moyle, Sarah, Berrie, Eleanor, Lawrie, Alison M, Wu, Yimin, Ellis, Ruth D, Hill, Adrian V S, Draper, Simon J

“…The development of effective vaccines against difficult disease targets will require the identification of new subunit vaccination strategies that can induce…”
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Safety and immunogenicity of heterologous prime-boost immunisation with Plasmodium falciparum malaria candidate vaccines, ChAd63 ME-TRAP and MVA ME-TRAP, in healthy Gambian and Kenyan adults by Ogwang, Caroline, Afolabi, Muhammed, Kimani, Domtila, Jagne, Ya Jankey, Sheehy, Susanne H, Bliss, Carly M, Duncan, Christopher J A, Collins, Katharine A, Garcia Knight, Miguel A, Kimani, Eva, Anagnostou, Nicholas A, Berrie, Eleanor, Moyle, Sarah, Gilbert, Sarah C, Spencer, Alexandra J, Soipei, Peninah, Mueller, Jenny, Okebe, Joseph, Colloca, Stefano, Cortese, Riccardo, Viebig, Nicola K, Roberts, Rachel, Gantlett, Katherine, Lawrie, Alison M, Nicosia, Alfredo, Imoukhuede, Egeruan B, Bejon, Philip, Urban, Britta C, Flanagan, Katie L, Ewer, Katie J, Chilengi, Roma, Hill, Adrian V S, Bojang, Kalifa

“…Heterologous prime boost immunization with chimpanzee adenovirus 63 (ChAd63) and Modified vaccinia Virus Ankara (MVA) vectored vaccines is a strategy recently…”
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Repeat controlled human malaria infection of healthy UK adults with blood-stage Plasmodium falciparum: Safety and parasite growth dynamics by Salkeld, Jo, Themistocleous, Yrene, Barrett, Jordan R., Mitton, Celia H., Rawlinson, Thomas A., Payne, Ruth O., Hou, Mimi M., Khozoee, Baktash, Edwards, Nick J., Nielsen, Carolyn M., Sandoval, Diana Muñoz, Bach, Florian A., Nahrendorf, Wiebke, Ramon, Raquel Lopez, Baker, Megan, Ramos-Lopez, Fernando, Folegatti, Pedro M., Quinkert, Doris, Ellis, Katherine J., Poulton, Ian D., Lawrie, Alison M., Cho, Jee-Sun, Nugent, Fay L., Spence, Philip J., Silk, Sarah E., Draper, Simon J., Minassian, Angela M.

“…In endemic settings it is known that natural malaria immunity is gradually acquired following repeated exposures. Here we sought to assess whether similar…”
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Controlled human malaria infection with a clone of Plasmodium vivax with high-quality genome assembly by Minassian, Angela M, Themistocleous, Yrene, Silk, Sarah E, Barrett, Jordan R, Kemp, Alison, Quinkert, Doris, Nielsen, Carolyn M, Edwards, Nick J, Rawlinson, Thomas A, Ramos Lopez, Fernando, Roobsoong, Wanlapa, Ellis, Katherine Jd, Cho, Jee-Sun, Aunin, Eerik, Otto, Thomas D, Reid, Adam J, Bach, Florian A, Labbé, Geneviève Mc, Poulton, Ian D, Marini, Arianna, Zaric, Marija, Mulatier, Margaux, Lopez Ramon, Raquel, Baker, Megan, Mitton, Celia H, Sousa, Jason C, Rachaphaew, Nattawan, Kumpitak, Chalermpon, Maneechai, Nongnuj, Suansomjit, Chayanut, Piteekan, Tianrat, Hou, Mimi M, Khozoee, Baktash, McHugh, Kirsty, Roberts, David J, Lawrie, Alison M, Blagborough, Andrew M, Nugent, Fay L, Taylor, Iona J, Johnson, Kimberly J, Spence, Philip J, Sattabongkot, Jetsumon, Biswas, Sumi, Rayner, Julian C, Draper, Simon J

“…Controlled human malaria infection (CHMI) provides a highly informative means to investigate host-pathogen interactions and enable in vivo proof-of-concept…”
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Safety and Immunogenicity of Malaria Vectored Vaccines Given with Routine Expanded Program on Immunization Vaccines in Gambian Infants and Neonates: A Randomized Controlled Trial by Mensah, Victorine A, Roetynck, Sophie, Kanteh, Ebrima K, Bowyer, Georgina, Ndaw, Amy, Oko, Francis, Bliss, Carly M, Jagne, Ya Jankey, Cortese, Riccardo, Nicosia, Alfredo, Roberts, Rachel, D'Alessio, Flavia, Leroy, Odile, Faye, Babacar, Kampmann, Beate, Cisse, Badara, Bojang, Kalifa, Gerry, Stephen, Viebig, Nicola K, Lawrie, Alison M, Clarke, Ed, Imoukhuede, Egeruan B, Ewer, Katie J, Hill, Adrian V S, Afolabi, Muhammed O

“…Heterologous prime-boost vaccination with chimpanzee adenovirus 63 (ChAd63) and modified vaccinia virus Ankara (MVA) encoding multiple epitope string…”
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Safety and Immunogenicity of a Novel Recombinant Simian Adenovirus ChAdOx2 as a Vectored Vaccine by Folegatti, Pedro M, Bellamy, Duncan, Roberts, Rachel, Powlson, Jonathan, Edwards, Nick J, Mair, Catherine F, Bowyer, Georgina, Poulton, Ian, Mitton, Celia H, Green, Nicky, Berrie, Eleanor, Lawrie, Alison M, Hill, Adrian V S, Ewer, Katie J, Hermon-Taylor, John, Gilbert, Sarah C

“…Adenovirus vectored vaccines are a highly effective strategy to induce cellular immune responses which are particularly effective against intracellular…”
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Safety and Immunogenicity of Adenovirus and Poxvirus Vectored Vaccines against a Mycobacterium Avium Complex Subspecies by Folegatti, Pedro M, Flaxman, Amy, Jenkin, Daniel, Makinson, Rebecca, Kingham-Page, Lucy, Bellamy, Duncan, Ramos Lopez, Fernando, Sheridan, Jonathan, Poulton, Ian, Aboagye, Jeremy, Tran, Nguyen, Mitton, Celia, Roberts, Rachel, Lawrie, Alison M, Hill, Adrian V S, Ewer, Katie J, Gilbert, Sarah

“…Heterologous prime-boost strategies are known to substantially increase immune responses in viral vectored vaccines. Here we report on safety and…”
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Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation by Ewer, Katie J., O’Hara, Geraldine A., Duncan, Christopher J. A., Collins, Katharine A., Sheehy, Susanne H., Reyes-Sandoval, Arturo, Goodman, Anna L., Edwards, Nick J., Elias, Sean C., Halstead, Fenella D., Longley, Rhea J., Rowland, Rosalind, Poulton, Ian D., Draper, Simon J., Blagborough, Andrew M., Berrie, Eleanor, Moyle, Sarah, Williams, Nicola, Siani, Loredana, Folgori, Antonella, Colloca, Stefano, Sinden, Robert E., Lawrie, Alison M., Cortese, Riccardo, Gilbert, Sarah C., Nicosia, Alfredo, Hill, Adrian V. S.

“…Induction of antigen-specific CD8 + T cells offers the prospect of immunization against many infectious diseases, but no subunit vaccine has induced CD8 + T…”
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Clinical Assessment of a Recombinant Simian Adenovirus ChAd63: A Potent New Vaccine Vector by O'Hara, Geraldine A., Duncan, Christopher J. A., Ewer, Katie J., Collins, Katharine A., Elias, Sean C., Halstead, Fenella D., Goodman, Anna L., Edwards, Nick J., Reyes-Sandoval, Arturo, Bird, Prudence, Rowland, Rosalind, Sheehy, Susanne H., Poulton, Ian D., Hutchings, Claire, Todryk, Stephen, Andrews, Laura, Folgori, Antonella, Berrie, Eleanor, Moyle, Sarah, Nicosia, Alfredo, Colloca, Stefano, Cortese, Riccardo, Siani, Loredana, Lawrie, Alison M., Gilbert, Sarah C., Hill, Adrian V. S.

“…Background. Vaccine development in human Plasmodium falciparum malaria has been hampered by the exceptionally high levels of CD8⁺ T cells required for…”
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Safety and High Level Efficacy of the Combination Malaria Vaccine Regimen of RTS,S/AS01B With Chimpanzee Adenovirus 63 and Modified Vaccinia Ankara Vectored Vaccines Expressing ME-TRAP by Rampling, Tommy, Ewer, Katie J, Bowyer, Georgina, Bliss, Carly M, Edwards, Nick J, Wright, Danny, Payne, Ruth O, Venkatraman, Navin, de Barra, Eoghan, Snudden, Claudia M, Poulton, Ian D, de Graaf, Hans, Sukhtankar, Priya, Roberts, Rachel, Ivinson, Karen, Weltzin, Rich, Rajkumar, Bebi-Yassin, Wille-Reece, Ulrike, Lee, Cynthia K, Ockenhouse, Christian F, Sinden, Robert E, Gerry, Stephen, Lawrie, Alison M, Vekemans, Johan, Morelle, Danielle, Lievens, Marc, Ballou, Ripley W, Cooke, Graham S, Faust, Saul N, Gilbert, Sarah, Hill, Adrian V S

“…The need for a highly efficacious vaccine against Plasmodium falciparum remains pressing. In this controlled human malaria infection (CHMI) study, we assessed…”
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Demonstration of the Blood-Stage Plasmodium falciparum Controlled Human Malaria Infection Model to Assess Efficacy of the P. falciparum Apical Membrane Antigen 1 Vaccine, FMP2.1/AS01 by Payne, Ruth O., Milne, Kathryn H., Elias, Sean C., Edwards, Nick J., Douglas, Alexander D., Brown, Rebecca E., Silk, Sarah E., Biswas, Sumi, Miura, Kazutoyo, Roberts, Rachel, Rampling, Thomas W., Venkatraman, Navin, Hodgson, Susanne H., Labbé, Geneviève M., Halstead, Fenella D., Poulton, Ian D., Nugent, Fay L., de Graaf, Hans, Sukhtankar, Priya, Williams, Nicola C., Ockenhouse, Christian F., Kathcart, April K., Qabar, Aziz N., Waters, Norman C., Soisson, Lorraine A., Birkett, Ashley J., Cooke, Graham S., Faust, Saul N., Woods, Colleen, Ivinson, Karen, McCarthy, James S., Diggs, Carter L., Vekemans, Johan, Long, Carole A., Hill, Adrian V. S., Lawrie, Alison M., Dutta, Sheetij, Draper, Simon J.

“…Background. Models of controlled human malaria infection (CHMI) initiated by mosquito bite have been widely used to assess efficacy of preerythrocytic vaccine…”
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