Search Results - "Lawrence H. Boise"

How I treat high-risk myeloma by Lonial, Sagar, Boise, Lawrence H., Kaufman, Jonathan

“…The treatment of patients with myeloma has dramatically changed over the past decade due in part to the development of new agents and myeloma-specific targets…”
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Cell of Origin and Genetic Alterations in the Pathogenesis of Multiple Myeloma by Barwick, Benjamin G, Gupta, Vikas A, Vertino, Paula M, Boise, Lawrence H

“…B cell activation and differentiation yields plasma cells with high affinity antibodies to a given antigen in a time-frame that allows for host protection…”
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Stromal Support of Metabolic Function through Mitochondrial Transfer in Multiple Myeloma by Boise, Lawrence H, Shanmugam, Mala

“…Marlein and colleagues demonstrate in multiple myeloma, bone marrow stromal cells transfer mitochondria to myeloma cells to increase cellular respiration,…”
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Multiple myeloma immunoglobulin lambda translocations portend poor prognosis by Barwick, Benjamin G., Neri, Paola, Bahlis, Nizar J., Nooka, Ajay K., Dhodapkar, Madhav V., Jaye, David L., Hofmeister, Craig C., Kaufman, Jonathan L., Gupta, Vikas A., Auclair, Daniel, Keats, Jonathan J., Lonial, Sagar, Vertino, Paula M., Boise, Lawrence H.

“…Multiple myeloma is a malignancy of antibody-secreting plasma cells. Most patients benefit from current therapies, however, 20% of patients relapse or die…”
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Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma by Bajpai, Richa, Sharma, Aditi, Achreja, Abhinav, Edgar, Claudia L., Wei, Changyong, Siddiqa, Arusha A., Gupta, Vikas A., Matulis, Shannon M., McBrayer, Samuel K., Mittal, Anjali, Rupji, Manali, Barwick, Benjamin G., Lonial, Sagar, Nooka, Ajay K., Boise, Lawrence H., Nagrath, Deepak, Shanmugam, Mala

“…The BCL-2 antagonist venetoclax is highly effective in multiple myeloma (MM) patients exhibiting the 11;14 translocation, the mechanistic basis of which is…”
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MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation by Jin, Lingtao, Chun, Jaemoo, Pan, Chaoyun, Li, Dan, Lin, Ruiting, Alesi, Gina N., Wang, Xu, Kang, Hee-Bum, Song, Lina, Wang, Dongsheng, Zhang, Guojing, Fan, Jun, Boggon, Titus J., Zhou, Lu, Kowalski, Jeanne, Qu, Cheng-Kui, Steuer, Conor E., Chen, Georgia Z., Saba, Nabil F., Boise, Lawrence H., Owonikoko, Taofeek K., Khuri, Fadlo R., Magliocca, Kelly R., Shin, Dong M., Lonial, Sagar, Kang, Sumin

“…Platinum-based chemotherapeutics represent a mainstay of cancer therapy, but resistance limits their curative potential. Through a kinome RNAi screen, we…”
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BCL2 dependency in diffuse large B-cell lymphoma: it's a family affair by Matulis, Shannon M, Boise, Lawrence H

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Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells by Obeng, Esther A., Carlson, Louise M., Gutman, Delia M., Harrington, William J., Lee, Kelvin P., Boise, Lawrence H.

“…Multiple myeloma (MM) is an incurable plasma cell malignancy. The 26S proteasome inhibitor, bortezomib, selectively induces apoptosis in MM cells; however, the…”
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MAX is an epigenetic sensor of 5-carboxylcytosine and is altered in multiple myeloma by Wang, Dongxue, Hashimoto, Hideharu, Zhang, Xing, Barwick, Benjamin G, Lonial, Sagar, Boise, Lawrence H, Vertino, Paula M, Cheng, Xiaodong

“…The oncogenic transcription factor MYC and its binding partner MAX regulate gene expression by binding to DNA at enhancer-box (E-box) elements 5΄-CACGTG-3΄. In…”
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The Tao of myeloma by Boise, Lawrence H., Kaufman, Jonathan L., Bahlis, Nizar J., Lonial, Sagar, Lee, Kelvin P.

“…Multiple myeloma is a plasma cell malignancy in which significant advances have been observed during the last 15 years. Our understanding of the disease has…”
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Ricolinostat (ACY‐1215) induced inhibition of aggresome formation accelerates carfilzomib‐induced multiple myeloma cell death by Mishima, Yuko, Santo, Loredana, Eda, Homare, Cirstea, Diana, Nemani, Neeharika, Yee, Andrew J., O'Donnell, Elizabeth, Selig, Martin Karl, Quayle, Steven N., Arastu‐Kapur, Shirin, Kirk, Christopher, Boise, Lawrence H., Jones, Simon S., Raje, Noopur

“…Summary Proteasome inhibition induces the accumulation of aggregated misfolded/ubiquitinated proteins in the aggresome; conversely, histone deacetylase 6…”
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MLN4924, an NAE inhibitor, suppresses AKT and mTOR signaling via upregulation of REDD1 in human myeloma cells by Gu, Yanyan, Kaufman, Jonathan L., Bernal, Leon, Torre, Claire, Matulis, Shannon M., Harvey, R. Donald, Chen, Jing, Sun, Shi-Yong, Boise, Lawrence H., Lonial, Sagar

“…The function and survival of normal and malignant plasma cells depends on the elaborately regulated ubiquitin proteasome system. Proteasome inhibitors such as…”
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Sustained antibody responses depend on CD28 function in bone marrow-resident plasma cells by Rozanski, Cheryl H, Arens, Ramon, Carlson, Louise M, Nair, Jayakumar, Boise, Lawrence H, Chanan-Khan, Asher A, Schoenberger, Stephen P, Lee, Kelvin P

“…Sustained long-term antibody levels are the cornerstone of protective immunity, yet it remains unclear how they are durably maintained. A predominant theory…”
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CD28-mediated pro-survival signaling induces chemotherapeutic resistance in multiple myeloma by Murray, Megan E., Gavile, Catherine M., Nair, Jayakumar R., Koorella, Chandana, Carlson, Louise M., Buac, Daniela, Utley, Adam, Chesi, Marta, Bergsagel, P. Leif, Boise, Lawrence H., Lee, Kelvin P.

“…Chemotherapeutic resistance remains a significant hurdle in the treatment of multiple myeloma (MM) and is significantly mediated by interactions between MM…”
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Phosphorylation alters Bim‐mediated Mcl‐1 stabilization and priming by Conage‐Pough, Jason E., Boise, Lawrence H.

“…Mcl‐1 is a highly labile protein, subject to extensive post‐translational regulation. This distinguishes Mcl‐1 from other antiapoptotic proteins and…”
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Regulation of antigen-specific T cell infiltration and spatial architecture in multiple myeloma and premalignancy by Robinson, M Hope, Villa, Nancy Y, Jaye, David L, Nooka, Ajay K, Duffy, Alyssa, McCachren, Samuel S, Manalo, Julia, Switchenko, Jeffrey M, Barnes, Sierra, Potdar, Sayalee, Azeem, Maryam I, Horvat, Ava A, Parihar, Vaunita C, Gong, Jingjing, Liang, Yan, Smith, Geoffrey H, Gupta, Vikas A, Boise, Lawrence H, Kaufman, Jonathan L, Hofmeister, Craig C, Joseph, Nisha S, Lonial, Sagar, Dhodapkar, Kavita M, Dhodapkar, Madhav V

“…Entry of antigen-specific T cells into human tumors is critical for immunotherapy, but the underlying mechanisms are poorly understood. Here, we combined…”
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Game of Bones: How Myeloma Manipulates Its Microenvironment by Moser-Katz, Tyler, Joseph, Nisha S, Dhodapkar, Madhav V, Lee, Kelvin P, Boise, Lawrence H

“…Multiple myeloma is a clonal disease of long-lived plasma cells and is the second most common hematological cancer behind Non-Hodgkin's Lymphoma. Malignant…”
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Bortezomib-induced “BRCAness” sensitizes multiple myeloma cells to PARP inhibitors by Neri, Paola, Ren, Li, Gratton, Kathy, Stebner, Erin, Johnson, Jordan, Klimowicz, Alexander, Duggan, Peter, Tassone, Pierfrancesco, Mansoor, Adnan, Stewart, Douglas A., Lonial, Sagar, Boise, Lawrence H., Bahlis, Nizar J.

“…Chromosomal instability is a defining feature of clonal myeloma plasma cells that results in the perpetual accumulation of genomic aberrations. In addition to…”
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β adrenergic signaling regulates hematopoietic stem and progenitor cell commitment and therapy sensitivity in multiple myeloma by Nair, Remya, Subramaniam, Vimal, Barwick, Benjamin G., Gupta, Vikas A., Matulis, Shannon M., Lonial, Sagar, Boise, Lawrence H., Nooka, Ajay K., Muthumalaiappan, Kuzhali, Shanmugam, Mala

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Integrin β7-mediated regulation of multiple myeloma cell adhesion, migration, and invasion by Neri, Paola, Ren, Li, Azab, Abdel Kareem, Brentnall, Matthew, Gratton, Kathy, Klimowicz, Alexander C., Lin, Charles, Duggan, Peter, Tassone, Pierfrancesco, Mansoor, Adnan, Stewart, Douglas A., Boise, Lawrence H., Ghobrial, Irene M., Bahlis, Nizar J.

“…Integrin-β7 (ITGB7) mRNA is detected in multiple myeloma (MM) cells and its presence is correlated with MAF gene activation. Although the involvement of…”
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