Search Results - "Lawrence, Theodore S."

Molecular Pathways: Overcoming Radiation Resistance by Targeting DNA Damage Response Pathways by Morgan, Meredith A, Lawrence, Theodore S

“…DNA double-strand breaks are the critical lesions responsible for the majority of ionizing radiation-induced cell killing. Thus, the ability of tumor cells to…”
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Outcomes After Stereotactic Body Radiotherapy or Radiofrequency Ablation for Hepatocellular Carcinoma by Wahl, Daniel R, Stenmark, Matthew H, Tao, Yebin, Pollom, Erqi L, Caoili, Elaine M, Lawrence, Theodore S, Schipper, Matthew J, Feng, Mary

“…Data guiding selection of nonsurgical treatment of hepatocellular carcinoma (HCC) are lacking. We therefore compared outcomes between stereotactic body…”
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Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression by Lin, Heng, Wei, Shuang, Hurt, Elaine M, Green, Michael D, Zhao, Lili, Vatan, Linda, Szeliga, Wojciech, Herbst, Ronald, Harms, Paul W, Fecher, Leslie A, Vats, Pankaj, Chinnaiyan, Arul M, Lao, Christopher D, Lawrence, Theodore S, Wicha, Max, Hamanishi, Junzo, Mandai, Masaki, Kryczek, Ilona, Zou, Weiping

“…Programmed death-1 receptor (PD-L1, B7-H1) and programmed cell death protein 1 (PD-1) pathway blockade is a promising therapy for treating cancer. However, the…”
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Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11 by Lang, Xueting, Green, Michael D, Wang, Weimin, Yu, Jiali, Choi, Jae Eun, Jiang, Long, Liao, Peng, Zhou, Jiajia, Zhang, Qiang, Dow, Ania, Saripalli, Anjali L, Kryczek, Ilona, Wei, Shuang, Szeliga, Wojciech, Vatan, Linda, Stone, Everett M, Georgiou, George, Cieslik, Marcin, Wahl, Daniel R, Morgan, Meredith A, Chinnaiyan, Arul M, Lawrence, Theodore S, Zou, Weiping

“…A challenge in oncology is to rationally and effectively integrate immunotherapy with traditional modalities, including radiotherapy. Here, we demonstrate that…”
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Inhibition of ATM Increases Interferon Signaling and Sensitizes Pancreatic Cancer to Immune Checkpoint Blockade Therapy by Zhang, Qiang, Green, Michael D, Lang, Xueting, Lazarus, Jenny, Parsels, Joshua D, Wei, Shuang, Parsels, Leslie A, Shi, Jiaqi, Ramnath, Nithya, Wahl, Daniel R, Pasca di Magliano, Marina, Frankel, Timothy L, Kryczek, Ilona, Lei, Yu L, Lawrence, Theodore S, Zou, Weiping, Morgan, Meredith A

“…Combinatorial strategies are needed to overcome the resistance of pancreatic cancer to immune checkpoint blockade (ICB). DNA damage activates the innate immune…”
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FBXW7 Facilitates Nonhomologous End-Joining via K63-Linked Polyubiquitylation of XRCC4 by Zhang, Qiang, Karnak, David, Tan, Mingjia, Lawrence, Theodore S., Morgan, Meredith A., Sun, Yi

“…FBXW7 is a haploinsufficient tumor suppressor with loss-of-function mutations occurring in human cancers. FBXW7 inactivation causes genomic instability, but…”
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MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells by Ji, Qing, Hao, Xinbao, Zhang, Min, Tang, Wenhua, Yang, Meng, Li, Ling, Xiang, Debing, Desano, Jeffrey T, Bommer, Guido T, Fan, Daiming, Fearon, Eric R, Lawrence, Theodore S, Xu, Liang

“…MicroRNAs (miRNAs) have been implicated in cancer initiation and progression via their ability to affect expression of genes and proteins that regulate cell…”
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Stereotactic Body Radiation Therapy as an Alternative to Transarterial Chemoembolization for Hepatocellular Carcinoma by Sapir, Eli, Tao, Yebin, Schipper, Matthew J., Bazzi, Latifa, Novelli, Paula M., Devlin, Pauline, Owen, Dawn, Cuneo, Kyle C., Lawrence, Theodore S., Parikh, Neehar D., Feng, Mary

“…To conduct a large single-institution comparison of transarterial chemoembolization (TACE) and stereotactic body radiation therapy (SBRT) outcomes in similar…”
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Cardiac Events After Radiation Therapy: Combined Analysis of Prospective Multicenter Trials for Locally Advanced Non-Small-Cell Lung Cancer by Dess, Robert T, Sun, Yilun, Matuszak, Martha M, Sun, Grace, Soni, Payal D, Bazzi, Latifa, Murthy, Venkatesh L, Hearn, Jason W D, Kong, Feng-Ming, Kalemkerian, Gregory P, Hayman, James A, Ten Haken, Randall K, Lawrence, Theodore S, Schipper, Matthew J, Jolly, Shruti

“…Purpose Radiation therapy is a critical component in the care of patients with non-small-cell lung cancer (NSCLC), yet cardiac injury after treatment is a…”
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PD-L1 Expression in Circulating Tumor Cells Increases during Radio(chemo)therapy and Indicates Poor Prognosis in Non-small Cell Lung Cancer by Wang, Yang, Kim, Tae Hyun, Fouladdel, Shamileh, Zhang, Zhuo, Soni, Payal, Qin, Angel, Zhao, Lili, Azizi, Ebrahim, Lawrence, Theodore S., Ramnath, Nithya, Cuneo, Kyle C., Nagrath, Sunitha

“…Preclinical studies demonstrated that radiation up-regulates PD-L1 expression in tumor cells, providing a rationale for combining PD-1/PD-L1 inhibitors with…”
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Long term outcomes of stereotactic body radiation therapy for hepatocellular carcinoma without macrovascular invasion by Mathew, Ashwathy Susan, Atenafu, Eshetu G., Owen, Dawn, Maurino, Chris, Brade, Anthony, Brierley, James, Dinniwell, Robert, Kim, John, Cho, Charles, Ringash, Jolie, Wong, Rebecca, Cuneo, Kyle, Feng, Mary, Lawrence, Theodore S., Dawson, Laura A.

“…Stereotactic Body Radiation Therapy (SBRT) is a non-invasive ablative treatment for hepatocellular carcinoma (HCC). This report aimed to address the limited…”
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Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression by Lin, Heng, Wei, Shuang, Hurt, Elaine M, Green, Michael D, Zhao, Lili, Vatan, Linda, Szeliga, Wojciech, Herbst, Ronald, Harms, Paul W, Fecher, Leslie A, Vats, Pankaj, Chinnaiyan, Arul M, Lao, Christopher D, Lawrence, Theodore S, Wicha, Max, Hamanishi, Junzo, Mandai, Masaki, Kryczek, Ilona, Zou, Weiping

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The Long Non-Coding RNA PCAT-1 Promotes Prostate Cancer Cell Proliferation through cMyc by Prensner, John R, Chen, Wei, Han, Sumin, Iyer, Matthew K, Cao, Qi, Kothari, Vishal, Evans, Joseph R, Knudsen, Karen E, Paulsen, Michelle T, Ljungman, Mats, Lawrence, Theodore S, Chinnaiyan, Arul M, Feng, Felix Y

“…Abstract Long non-coding RNAs (lncRNAs) represent an emerging layer of cancer biology, contributing to tumor proliferation, invasion, and metastasis. Here, we…”
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PCAT-1, a Long Noncoding RNA, Regulates BRCA2 and Controls Homologous Recombination in Cancer by PRENSNER, John R, WEI CHEN, LOGOTHETIS, Christopher J, ARAUJO, John C, PISTERS, Louis L, TEWARI, Ashutosh K, CANMAN, Christine E, KNUDSEN, Karen E, KITABAYASHI, Naoki, RUBIN, Mark A, DEMICHELIS, Francesca, LAWRENCE, Theodore S, IYER, Matthew K, CHINNAIYAN, Arul M, FENG, Felix Y, QI CAO, TENG MA, SUMIN HAN, SAHU, Anirban, MALIK, Rohit, WILDER-ROMANS, Kari, NAVONE, Nora

“…Impairment of double-stranded DNA break (DSB) repair is essential to many cancers. However, although mutations in DSB repair proteins are common in hereditary…”
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Diffusion tensor imaging predicts cognitive function change following partial brain radiotherapy for low-grade and benign tumors by Chapman, Christopher H, Zhu, Tong, Nazem-Zadeh, Mohamad, Tao, Yebin, Buchtel, Henry A, Tsien, Christina I, Lawrence, Theodore S, Cao, Yue

“…Abstract Purpose/objectives Radiation injury to parahippocampal cingulum white matter is associated with cognitive decline. Diffusion tensor imaging (DTI)…”
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Comparison of Stereotactic Body Radiation Therapy and Radiofrequency Ablation in the Treatment of Intrahepatic Metastases by Jackson, William C., Tao, Yebin, Mendiratta-Lala, Mishal, Bazzi, Latifa, Wahl, Dan R., Schipper, Matthew J., Feng, Mary, Cuneo, Kyle C., Lawrence, Theodore S., Owen, Dawn

“…Stereotactic body radiation therapy (SBRT) and radiofrequency ablation (RFA) are widely used therapies for the treatment of intrahepatic metastases; however,…”
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Combined inhibition of Wee1 and PARP1/2 for radiosensitization in pancreatic cancer by Karnak, David, Engelke, Carl G, Parsels, Leslie A, Kausar, Tasneem, Wei, Dongping, Robertson, Jordan R, Marsh, Katherine B, Davis, Mary A, Zhao, Lili, Maybaum, Jonathan, Lawrence, Theodore S, Morgan, Meredith A

“…While the addition of radiation to chemotherapy improves survival in patients with locally advanced pancreatic cancer, more effective therapies are urgently…”
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Maternal Embryonic Leucine Zipper Kinase (MELK) as a Novel Mediator and Biomarker of Radioresistance in Human Breast Cancer by Speers, Corey, Zhao, Shuang G, Kothari, Vishal, Santola, Alyssa, Liu, Meilan, Wilder-Romans, Kari, Evans, Joseph, Batra, Nidhi, Bartelink, Harry, Hayes, Daniel F, Lawrence, Theodore S, Brown, Powel H, Pierce, Lori J, Feng, Felix Y

“…While effective targeted therapies exist for estrogen receptor-positive and HER2-positive breast cancer, no such effective therapies exist for triple-negative…”
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TTK inhibition radiosensitizes basal-like breast cancer through impaired homologous recombination by Chandler, Benjamin C, Moubadder, Leah, Ritter, Cassandra L, Liu, Meilan, Cameron, Meleah, Wilder-Romans, Kari, Zhang, Amanda, Pesch, Andrea M, Michmerhuizen, Anna R, Hirsh, Nicole, Androsiglio, Marlie, Ward, Tanner, Olsen, Eric, Niknafs, Yashar S, Merajver, Sofia, Thomas, Dafydd G, Brown, Powel H, Lawrence, Theodore S, Nyati, Shyam, Pierce, Lori J, Chinnaiyan, Arul, Speers, Corey

“…Increased rates of locoregional recurrence are observed in patients with basal-like breast cancer (BC) despite the use of radiation therapy (RT); therefore,…”
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Antibody Against CD44s Inhibits Pancreatic Tumor Initiation and Postradiation Recurrence in Mice by Li, Ling, Hao, Xinbao, Qin, Jun, Tang, Wenhua, He, Fengtian, Smith, Amber, Zhang, Min, Simeone, Diane M, Qiao, Xiaotan T, Chen, Zhi-Nan, Lawrence, Theodore S, Xu, Liang

“…Background & Aims CD44s is a surface marker of tumor-initiating cells (TICs); high tumor levels correlate with metastasis and recurrence, as well as poor…”
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