Search Results - "Lawrence, Theodore"

Molecular Pathways: Overcoming Radiation Resistance by Targeting DNA Damage Response Pathways by Morgan, Meredith A, Lawrence, Theodore S

“…DNA double-strand breaks are the critical lesions responsible for the majority of ionizing radiation-induced cell killing. Thus, the ability of tumor cells to…”
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CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy by Wang, Weimin, Green, Michael, Choi, Jae Eun, Gijón, Miguel, Kennedy, Paul D., Johnson, Jeffrey K., Liao, Peng, Lang, Xueting, Kryczek, Ilona, Sell, Amanda, Xia, Houjun, Zhou, Jiajia, Li, Gaopeng, Li, Jing, Li, Wei, Wei, Shuang, Vatan, Linda, Zhang, Hongjuan, Szeliga, Wojciech, Gu, Wei, Liu, Rebecca, Lawrence, Theodore S., Lamb, Candice, Tanno, Yuri, Cieslik, Marcin, Stone, Everett, Georgiou, George, Chan, Timothy A., Chinnaiyan, Arul, Zou, Weiping

“…Cancer immunotherapy restores or enhances the effector function of CD8 + T cells in the tumour microenvironment 1 , 2 . CD8 + T cells activated by cancer…”
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Revising a Research Paper by Lawrence, Theodore S.

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Outcomes After Stereotactic Body Radiotherapy or Radiofrequency Ablation for Hepatocellular Carcinoma by Wahl, Daniel R, Stenmark, Matthew H, Tao, Yebin, Pollom, Erqi L, Caoili, Elaine M, Lawrence, Theodore S, Schipper, Matthew J, Feng, Mary

“…Data guiding selection of nonsurgical treatment of hepatocellular carcinoma (HCC) are lacking. We therefore compared outcomes between stereotactic body…”
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Writing a Research Paper by Lawrence, Theodore S.

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Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression by Lin, Heng, Wei, Shuang, Hurt, Elaine M, Green, Michael D, Zhao, Lili, Vatan, Linda, Szeliga, Wojciech, Herbst, Ronald, Harms, Paul W, Fecher, Leslie A, Vats, Pankaj, Chinnaiyan, Arul M, Lao, Christopher D, Lawrence, Theodore S, Wicha, Max, Hamanishi, Junzo, Mandai, Masaki, Kryczek, Ilona, Zou, Weiping

“…Programmed death-1 receptor (PD-L1, B7-H1) and programmed cell death protein 1 (PD-1) pathway blockade is a promising therapy for treating cancer. However, the…”
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Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11 by Lang, Xueting, Green, Michael D, Wang, Weimin, Yu, Jiali, Choi, Jae Eun, Jiang, Long, Liao, Peng, Zhou, Jiajia, Zhang, Qiang, Dow, Ania, Saripalli, Anjali L, Kryczek, Ilona, Wei, Shuang, Szeliga, Wojciech, Vatan, Linda, Stone, Everett M, Georgiou, George, Cieslik, Marcin, Wahl, Daniel R, Morgan, Meredith A, Chinnaiyan, Arul M, Lawrence, Theodore S, Zou, Weiping

“…A challenge in oncology is to rationally and effectively integrate immunotherapy with traditional modalities, including radiotherapy. Here, we demonstrate that…”
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Inhibition of ATM Increases Interferon Signaling and Sensitizes Pancreatic Cancer to Immune Checkpoint Blockade Therapy by Zhang, Qiang, Green, Michael D, Lang, Xueting, Lazarus, Jenny, Parsels, Joshua D, Wei, Shuang, Parsels, Leslie A, Shi, Jiaqi, Ramnath, Nithya, Wahl, Daniel R, Pasca di Magliano, Marina, Frankel, Timothy L, Kryczek, Ilona, Lei, Yu L, Lawrence, Theodore S, Zou, Weiping, Morgan, Meredith A

“…Combinatorial strategies are needed to overcome the resistance of pancreatic cancer to immune checkpoint blockade (ICB). DNA damage activates the innate immune…”
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FBXW7 Facilitates Nonhomologous End-Joining via K63-Linked Polyubiquitylation of XRCC4 by Zhang, Qiang, Karnak, David, Tan, Mingjia, Lawrence, Theodore S., Morgan, Meredith A., Sun, Yi

“…FBXW7 is a haploinsufficient tumor suppressor with loss-of-function mutations occurring in human cancers. FBXW7 inactivation causes genomic instability, but…”
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Stereotactic Body Radiation Therapy as an Alternative to Transarterial Chemoembolization for Hepatocellular Carcinoma by Sapir, Eli, Tao, Yebin, Schipper, Matthew J., Bazzi, Latifa, Novelli, Paula M., Devlin, Pauline, Owen, Dawn, Cuneo, Kyle C., Lawrence, Theodore S., Parikh, Neehar D., Feng, Mary

“…To conduct a large single-institution comparison of transarterial chemoembolization (TACE) and stereotactic body radiation therapy (SBRT) outcomes in similar…”
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Cardiac Events After Radiation Therapy: Combined Analysis of Prospective Multicenter Trials for Locally Advanced Non-Small-Cell Lung Cancer by Dess, Robert T, Sun, Yilun, Matuszak, Martha M, Sun, Grace, Soni, Payal D, Bazzi, Latifa, Murthy, Venkatesh L, Hearn, Jason W D, Kong, Feng-Ming, Kalemkerian, Gregory P, Hayman, James A, Ten Haken, Randall K, Lawrence, Theodore S, Schipper, Matthew J, Jolly, Shruti

“…Purpose Radiation therapy is a critical component in the care of patients with non-small-cell lung cancer (NSCLC), yet cardiac injury after treatment is a…”
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MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells by Ji, Qing, Hao, Xinbao, Zhang, Min, Tang, Wenhua, Yang, Meng, Li, Ling, Xiang, Debing, Desano, Jeffrey T, Bommer, Guido T, Fan, Daiming, Fearon, Eric R, Lawrence, Theodore S, Xu, Liang

“…MicroRNAs (miRNAs) have been implicated in cancer initiation and progression via their ability to affect expression of genes and proteins that regulate cell…”
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Purine metabolism regulates DNA repair and therapy resistance in glioblastoma by Zhou, Weihua, Yao, Yangyang, Scott, Andrew J., Wilder-Romans, Kari, Dresser, Joseph J., Werner, Christian K., Sun, Hanshi, Pratt, Drew, Sajjakulnukit, Peter, Zhao, Shuang G., Davis, Mary, Nelson, Barbara S., Halbrook, Christopher J., Zhang, Li, Gatto, Francesco, Umemura, Yoshie, Walker, Angela K., Kachman, Maureen, Sarkaria, Jann N., Xiong, Jianping, Morgan, Meredith A., Rehemtualla, Alnawaz, Castro, Maria G., Lowenstein, Pedro, Chandrasekaran, Sriram, Lawrence, Theodore S., Lyssiotis, Costas A., Wahl, Daniel R.

“…Intratumoral genomic heterogeneity in glioblastoma (GBM) is a barrier to overcoming therapy resistance. Treatments that are effective independent of genotype…”
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Dose Escalation Trial of the Wee1 Inhibitor Adavosertib (AZD1775) in Combination With Gemcitabine and Radiation for Patients With Locally Advanced Pancreatic Cancer by Cuneo, Kyle C, Morgan, Meredith A, Sahai, Vaibhav, Schipper, Matthew J, Parsels, Leslie A, Parsels, Joshua D, Devasia, Theresa, Al-Hawaray, Mahmoud, Cho, Clifford S, Nathan, Hari, Maybaum, Jonathan, Zalupski, Mark M, Lawrence, Theodore S

“…AZD1775 (adavosertib) is an inhibitor of the Wee1 kinase. In this study, we built on our preclinical studies to evaluate the safety and efficacy of AZD1775 in…”
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PD-L1 Expression in Circulating Tumor Cells Increases during Radio(chemo)therapy and Indicates Poor Prognosis in Non-small Cell Lung Cancer by Wang, Yang, Kim, Tae Hyun, Fouladdel, Shamileh, Zhang, Zhuo, Soni, Payal, Qin, Angel, Zhao, Lili, Azizi, Ebrahim, Lawrence, Theodore S., Ramnath, Nithya, Cuneo, Kyle C., Nagrath, Sunitha

“…Preclinical studies demonstrated that radiation up-regulates PD-L1 expression in tumor cells, providing a rationale for combining PD-1/PD-L1 inhibitors with…”
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Development of an abdominal dose accumulation tool and assessments of accumulated dose in gastrointestinal organs by Zhang, Yuhang, Balter, James, Dow, Janell, Cao, Yue, Lawrence, Theodore S, Kashani, Rojano

“…Online adaptive radiotherapy has demonstrated improved dose conformality in response to inter-fraction geometric variations in the abdomen. The dosimetric…”
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Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination by Yu, Jiali, Green, Michael D., Li, Shasha, Sun, Yilun, Journey, Sara N., Choi, Jae Eun, Rizvi, Syed Monem, Qin, Angel, Waninger, Jessica J., Lang, Xueting, Chopra, Zoey, El Naqa, Issam, Zhou, Jiajia, Bian, Yingjie, Jiang, Long, Tezel, Alangoya, Skvarce, Jeremy, Achar, Rohan K., Sitto, Merna, Rosen, Benjamin S., Su, Fengyun, Narayanan, Sathiya P., Cao, Xuhong, Wei, Shuang, Szeliga, Wojciech, Vatan, Linda, Mayo, Charles, Morgan, Meredith A., Schonewolf, Caitlin A., Cuneo, Kyle, Kryczek, Ilona, Ma, Vincent T., Lao, Christopher D., Lawrence, Theodore S., Ramnath, Nithya, Wen, Fei, Chinnaiyan, Arul M., Cieslik, Marcin, Alva, Ajjai, Zou, Weiping

“…Metastasis is the primary cause of cancer mortality, and cancer frequently metastasizes to the liver. It is not clear whether liver immune tolerance mechanisms…”
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Abdominal synthetic CT generation from MR Dixon images using a U-net trained with 'semi-synthetic' CT data by Liu, Lianli, Johansson, Adam, Cao, Yue, Dow, Janell, Lawrence, Theodore S, Balter, James M

“…Magnetic resonance imaging (MRI) is gaining popularity in guiding radiation treatment for intrahepatic cancers due to its superior soft tissue contrast and…”
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Blood–tumor barrier opening changes in brain metastases from pre to one-month post radiation therapy by Teng, Feifei, Tsien, Christina I., Lawrence, Theodore S., Cao, Yue

“…Blood–tumor barrier is a limiting factor for effectiveness of systemic therapy to brain metastases. This study aimed to assess the extent and time course of…”
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Long term outcomes of stereotactic body radiation therapy for hepatocellular carcinoma without macrovascular invasion by Mathew, Ashwathy Susan, Atenafu, Eshetu G., Owen, Dawn, Maurino, Chris, Brade, Anthony, Brierley, James, Dinniwell, Robert, Kim, John, Cho, Charles, Ringash, Jolie, Wong, Rebecca, Cuneo, Kyle, Feng, Mary, Lawrence, Theodore S., Dawson, Laura A.

“…Stereotactic Body Radiation Therapy (SBRT) is a non-invasive ablative treatment for hepatocellular carcinoma (HCC). This report aimed to address the limited…”
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