Search Results - "Lawrence, Shelley"

The Ontogeny of a Neutrophil: Mechanisms of Granulopoiesis and Homeostasis by Lawrence, Shelley M, Corriden, Ross, Nizet, Victor

“…Comprising the majority of leukocytes in humans, neutrophils are the first immune cells to respond to inflammatory or infectious etiologies and are crucial…”
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How Neutrophils Meet Their End by Lawrence, Shelley M., Corriden, Ross, Nizet, Victor

“…Neutrophil death can transpire via diverse pathways and is regulated by interactions with commensal and pathogenic microorganisms, environmental exposures, and…”
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Emerging Technologies for Molecular Diagnosis of Sepsis by Sinha, Mridu, Jupe, Julietta, Mack, Hannah, Coleman, Todd P, Lawrence, Shelley M, Fraley, Stephanie I

“…Rapid and accurate profiling of infection-causing pathogens remains a significant challenge in modern health care. Despite advances in molecular diagnostic…”
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Human cytomegalovirus and neonatal infection by Lawrence, Shelley M.

“…•This review highlights emerging discoveries into the pathogenesis of human cytomegalovirus, enabling the development of innovative diagnostics.•It details…”
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A broad-based probe-free qPCR assay for detection and discrimination of three human herpes viruses by Gupta, Anshu, Lawrence, Shelley M., Fraley, Stephanie I.

“…Primary infection or reactivation of latent human cytomegalovirus (HCMV) or herpes simplex viruses (HSV) 1 or 2 during pregnancy can transmit the virus in…”
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Decoding human cytomegalovirus for the development of innovative diagnostics to detect congenital infection by Lawrence, Shelley M., Goshia, Tyler, Sinha, Mridu, Fraley, Stephanie I., Williams, Marvin

“…Cytomegalovirus is the most common cause of congenital infectious disease and the leading nongenetic etiology of sensorineural hearing loss. Although most…”
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IL‐17 in neonatal health and disease by Lawrence, Shelley M., Ruoss, Jessica Lauren, Wynn, James L.

“…Over the last few years, scientific interest in the cytokine IL‐17A has intensified as its role in human health and disease has been elucidated. Discovered…”
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Chorioamnionitis, IL‐17A, and fetal origins of neurologic disease by Lawrence, Shelley M., Wynn, James L.

“…The Centers for Disease Control and Prevention estimate that 1 in 323 infants have cerebral palsy. Highly correlated to intrauterine infection and…”
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Alterations in neonatal neutrophil function attributable to increased immature forms by Makoni, Marjorie, Eckert, Jeffrey, Anne Pereira, H, Nizet, Victor, Lawrence, Shelley M

“…Abstract At birth neonatal neutrophil composition differs from that of adults due to a higher number of circulating immature forms. To date only a single study…”
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Severe anemia at birth – incidence and implications by Bahr, Timothy M., Lawrence, Shelley M., Henry, Erick, Ohls, Robin K., Li, Shihao, Christensen, Robert D.

“…To identify neonates with “severe anemia at birth”, defined by a hemoglobin/hematocrit within the first six hours after birth that plotted below the 1st…”
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Data-driven noise modeling of digital DNA melting analysis enables prediction of sequence discriminating power by Langouche, Lennart, Aralar, April, Sinha, Mridu, Lawrence, Shelley M, Fraley, Stephanie I, Coleman, Todd P

“…Abstract Motivation The need to rapidly screen complex samples for a wide range of nucleic acid targets, like infectious diseases, remains unmet. Digital…”
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Improving Quantitative Power in Digital PCR through Digital High-Resolution Melting by Aralar, April, Yuan, Yixu, Chen, Kevin, Geng, Yunshu, Ortiz Velez, Daniel, Sinha, Mridu, Lawrence, Shelley M, Fraley, Stephanie I

“…Applying digital PCR (dPCR) technology to challenging clinical and industrial detection tasks has become more prevalent because of its capability for absolute…”
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Fragmented red blood cell counts of neonates with new-onset gastrointestinal disturbances by Bahr, Timothy M., Christensen, Thomas R., Henry, Erick, Judkins, Allison J., Bennett, Sterling T., Pysher, Theodore J., Lawrence, Shelley M., Ohls, Robin K., Christensen, Robert D.

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Implications of an Elevated Nucleated Red Blood Cell Count in Neonates with Moderate to Severe Hypoxic-Ischemic Encephalopathy by Bahr, Timothy M., Ohls, Robin K., Baserga, Mariana C., Lawrence, Shelley M., Winter, Sarah L., Christensen, Robert D.

“…To investigate associations between nucleated red blood cell (NRBC) count in neonates with hypoxic-ischemic encephalopathy (HIE), acute perinatal sentinel…”
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Contribution of Concurrent Comorbidities to Sepsis-Related Mortality in Preterm Infants ≤32 Weeks of Gestation at an Academic Neonatal Intensive Care Network by Barnette, Brian W, Schumacher, Benjamin T, Armenta, Richard F, Wynn, James L, Richardson, Andrew, Bradley, John S, Lazar, Sarah, Lawrence, Shelley M

“…This study sought to identify concurrent major comorbidities in preterm infants ≤32 weeks of gestation that may have contributed to sepsis-related mortality…”
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Erythrocyte-Coated Nanoparticles Block Cytotoxic Effects of Group B Streptococcus β-Hemolysin/Cytolysin by Koo, Jenny, Escajadillo, Tamara, Zhang, Liangfang, Nizet, Victor, Lawrence, Shelley M.

“…Group B Streptococcus (GBS) emerged as a leading cause of invasive infectious disease in neonates in the 1970s, but has recently been identified as an…”
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Universal Digital High-Resolution Melt Analysis for the Diagnosis of Bacteremia by Aralar, April, Goshia, Tyler, Ramchandar, Nanda, Lawrence, Shelley M., Karmakar, Aparajita, Sharma, Ankit, Sinha, Mridu, Pride, David T., Kuo, Peiting, Lecrone, Khrissa, Chiu, Megan, Mestan, Karen K., Sajti, Eniko, Vanderpool, Michelle, Lazar, Sarah, Crabtree, Melanie, Tesfai, Yordanos, Fraley, Stephanie I.

“…Fast and accurate diagnosis of bloodstream infection is necessary to inform treatment decisions for septic patients, who face hourly increases in mortality…”
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Perinatal Carbon Monoxide Poisoning: Treatment of a 2-Hour-Old Neonate with Hyperbaric Oxygen by Kreshak, Allyson A, Lawrence, Shelley M, Ontiveros, Sam T, Castellano, Tiffany, VanHoesen, Karen B

“…A 41-year-old gravida 4 para 3 (G4P3) and 38 weeks pregnant woman presented to labor and delivery with dizziness, headache, and decreased fetal movement after…”
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Outcomes of Infants with Mild Hypoxic Ischemic Encephalopathy Who Did Not Receive Therapeutic Hypothermia by Reiss, Jonathan, Sinha, Mridu, Gold, Jeffrey, Bykowski, Julie, Lawrence, Shelley M.

“…Introduction: Accurately diagnosing and treating infants with mild forms of hypoxic ischemic encephalopathy (HIE) is important, as the majority of neonates…”
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FLLL32, a curcumin analog, ameliorates intestinal injury in necrotizing enterocolitis by Eckert, Jeffrey, Scott, Brian, Lawrence, Shelley M, Ihnat, Michael, Chaaban, Hala

“…Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease that primarily affects premature infants. It is characterized by inflammation and…”
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