Search Results - "Lawrence, John C"

PRAS40 Regulates mTORC1 Kinase Activity by Functioning as a Direct Inhibitor of Substrate Binding by Wang, Lifu, Harris, Thurl E., Roth, Richard A., Lawrence, John C.

“…Mammalian target of rapamycin (mTOR) functions in two distinct signaling complexes, mTORC1 and mTORC2. In response to insulin and nutrients, mTORC1, consisting…”
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Fat Cell-Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism by KUMAR, Anil, LAWRENCE, John C, DAE YOUNG JUNG, HWI JIN KO, KELLER, Susanna R, KIM, Jason K, MAGNUSON, Mark A, HARRIS, Thurl E

“…Rictor is an essential component of mammalian target of rapamycin (mTOR) complex (mTORC) 2, a kinase that phosphorylates and activates Akt, an insulin…”
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Regulation of Proline-rich Akt Substrate of 40 kDa (PRAS40) Function by Mammalian Target of Rapamycin Complex 1 (mTORC1)-mediated Phosphorylation by Wang, Lifu, Harris, Thurl E., Lawrence, John C.

“…The rapamycin-sensitive mammalian target of rapamycin (mTOR) complex 1 (mTORC1) contains mTOR, raptor, mLST8, and PRAS40 (proline-rich Akt substrate of 40…”
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Insulin Controls Subcellular Localization and Multisite Phosphorylation of the Phosphatidic Acid Phosphatase, Lipin 1 by Harris, Thurl E., Huffman, Todd A., Chi, An, Shabanowitz, Jeffrey, Hunt, Donald F., Kumar, Anil, Lawrence, John C.

“…Brain, liver, kidney, heart, and skeletal muscle from fatty liver dystrophy (fld/fld) mice, which do not express lipin 1 (lipin), contained much less…”
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Muscle-Specific Deletion of Rictor Impairs Insulin-Stimulated Glucose Transport and Enhances Basal Glycogen Synthase Activity by Kumar, Anil, Harris, Thurl E., Keller, Susanna R., Choi, Kin M., Magnuson, Mark A., Lawrence, John C.

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Lipin 1 Represses NFATc4 Transcriptional Activity in Adipocytes To Inhibit Secretion of Inflammatory Factors by Kim, Hyun Bae, Kumar, Anil, Wang, Lifu, Liu, Guang-Hui, Keller, Susanna R., Lawrence, John C., Finck, Brian N., Harris, Thurl E.

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conserved phosphatase cascade that regulates nuclear membrane biogenesis by Kim, Youngjun, Gentry, Matthew S, Harris, Thurl E, Wiley, Sandra E, Lawrence, John C. Jr, Dixon, Jack E

“…A newly emerging family of phosphatases that are members of the haloacid dehalogenase superfamily contains the catalytic motif DXDX(T/V). A member of this…”
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Mammalian Target of Rapamycin Complex 1 (mTORC1) Activity Is Associated with Phosphorylation of Raptor by mTOR by Wang, Lifu, Lawrence, John C., Sturgill, Thomas W., Harris, Thurl E.

“…mTORC1 contains multiple proteins and plays a central role in cell growth and metabolism. Raptor (regulatory-associated protein of mammalian target of…”
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Activation of Mammalian Target of Rapamycin (mTOR) by Insulin Is Associated with Stimulation of 4EBP1 Binding to Dimeric mTOR Complex 1 by Wang, Lifu, Rhodes, Christopher J., Lawrence, John C.

“…Insulin stimulates protein synthesis by promoting phosphorylation of the eIF4E-binding protein, 4EBP1. This effect is rapamycin-sensitive and mediated by…”
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Strategic use of serology for the diagnosis of bovine tuberculosis after intradermal skin testing by Casal, Carmen, Díez-Guerrier, Alberto, Álvarez, Julio, Rodriguez-Campos, Sabrina, Mateos, Ana, Linscott, Richard, Martel, Edmond, Lawrence, John C., Whelan, Clare, Clarke, John, O’Brien, Amanda, Domínguez, Lucas, Aranaz, Alicia

“…Diagnostic tests based on cell-mediated immunity are used in programmes for eradication of bovine tuberculosis (Mycobacterium bovis). Serological assays could…”
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Alterations in Hepatic Metabolism in fld Mice Reveal a Role for Lipin 1 in Regulating VLDL-Triacylglyceride Secretion by Chen, Zhouji, Gropler, Matthew C, Norris, Jin, Lawrence, John C, Harris, Thurl E, Finck, Brian N

“…OBJECTIVE—Lipin 1 controls fatty acid metabolism in the nucleus as a transcriptional regulator and in the cytosol as an enzyme catalyzing the penultimate step…”
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Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo by Bodine, Sue C, Yancopoulos, George D, Stitt, Trevor N, Gonzalez, Michael, Kline, William O, Stover, Gretchen L, Bauerlein, Roy, Zlotchenko, Elizabeth, Scrimgeour, Angus, Lawrence, John C, Glass, David J

“…Skeletal muscles adapt to changes in their workload by regulating fibre size by unknown mechanisms. The roles of two signalling pathways implicated in muscle…”
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mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin by Harris, Thurl E, Chi, An, Shabanowitz, Jeffrey, Hunt, Donald F, Rhoads, Robert E, Lawrence Jr, John C

“…Insulin stimulates protein synthesis by increasing translation initiation. This response is mediated by mTOR and is believed to result from 4EBP1…”
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Insulin-Stimulated Phosphorylation of Lipin Mediated by the Mammalian Target of Rapamycin by Huffman, Todd A., Mothe-Satney, Isabelle, Lawrence, John C.

“…The phosphorylation of a previously uncharacterized protein of apparent Mr≈ 140,000 was found to be increased when rat adipocytes were incubated with insulin…”
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Two Motifs in the Translational Repressor PHAS-I Required for Efficient Phosphorylation by Mammalian Target of Rapamycin and for Recognition by Raptor by Choi, Kin Man, McMahon, Lloyd P., Lawrence, John C.

“…Mammalian target of rapamycin (mTOR) is the central element of a signaling pathway involved in the control of mRNA translation and cell growth. The actions of…”
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Evaluation of a Commercial Enzyme-Linked Immunosorbent Assay for the Diagnosis of Bovine Tuberculosis from Milk Samples from Dairy Cows by Buddle, Bryce M, Wilson, Tania, Luo, Dongwen, Voges, Hinrich, Linscott, Richard, Martel, Edmond, Lawrence, John C, Neill, Mark A

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Protection Against Oxidative Stress—Induced Insulin Resistance in Rat L6 Muscle Cells by Micromolar Concentrations of α-Lipoic Acid by MADDUX, Betty A, SEE, Wendy, LAWRENCE, John C, GOLDFINE, Amy L, GOLDFINE, Ira D, EVANS, Joseph L

“…Protection Against Oxidative Stress—Induced Insulin Resistance in Rat L6 Muscle Cells by Micromolar Concentrations of α-Lipoic Acid Betty A. Maddux , Wendy See…”
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New insights into the role and mechanism of glycogen synthase activation by insulin by LAWRENCE, J. C, ROACH, P. J

“…The metabolism of the storage polysaccharide glycogen is intimately linked with insulin action and blood glucose homeostasis. Insulin activates both glucose…”
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The Rapamycin-Binding Domain Governs Substrate Selectivity by the Mammalian Target of Rapamycin by McMahon, Lloyd P., Choi, Kin M., Lin, Tai-An, Abraham, Robert T., Lawrence, John C.

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Evidence of Insulin-Stimulated Phosphorylation and Activation of the Mammalian Target of Rapamycin Mediated by a Protein Kinase B Signaling Pathway by Scott, Pamela H., Brunn, Gregory J., Kohn, Aimee D., Roth, Richard A., Lawrence, John C.

“…The effects of insulin on the mammalian target of rapamycin, mTOR, were investigated in 3T3-L1 adipocytes. mTOR protein kinase activity was measured in immune…”
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