Search Results - "Lawrence, I."

Fatal heart disease among cancer patients by Stoltzfus, Kelsey C., Zhang, Ying, Sturgeon, Kathleen, Sinoway, Lawrence I., Trifiletti, Daniel M., Chinchilli, Vernon M., Zaorsky, Nicholas G.

“…As the overlap between heart disease and cancer patients increases as cancer-specific mortality is decreasing and the surviving population is aging, it is…”
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Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations by Soldner, Frank, Laganière, Josée, Cheng, Albert W., Hockemeyer, Dirk, Gao, Qing, Alagappan, Raaji, Khurana, Vikram, Golbe, Lawrence I., Myers, Richard H., Lindquist, Susan, Zhang, Lei, Guschin, Dmitry, Fong, Lauren K., Vu, B. Joseph, Meng, Xiangdong, Urnov, Fyodor D., Rebar, Edward J., Gregory, Philip D., Zhang, H. Steve, Jaenisch, Rudolf

“…Patient-specific induced pluripotent stem cells (iPSCs) derived from somatic cells provide a unique tool for the study of human disease, as well as a promising…”
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Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches by Boxer, Adam L, Prof, Yu, Jin-Tai, Prof, Golbe, Lawrence I, Prof, Litvan, Irene, Prof, Lang, Anthony E, Prof, Höglinger, Günter U, Prof

“…Summary Progressive supranuclear palsy (PSP), previously believed to be a common cause of atypical parkinsonism, is now recognised as a range of motor and…”
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Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity by Romero, Roberto, Erez, Offer, Hüttemann, Maik, Maymon, Eli, Panaitescu, Bogdan, Conde-Agudelo, Agustin, Pacora, Percy, Yoon, Bo Hyun, Grossman, Lawrence I.

“…Metformin is everywhere. Originally introduced in clinical practice as an antidiabetic agent, its role as a therapeutic agent is expanding to include treatment…”
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John C. Steele, MD: 1934–2022 by Golbe, Lawrence I.

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The role of peripheral venous distension reflex in regulating hemodynamics: mini review by Hamaoka, Takuto, Sinoway, Lawrence I., Cui, Jian

“…Significant volume is pooled in veins in humans and the amount is dramatically altered by various physiological stresses and diseases. Several animal and human…”
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Metabolic costs and evolutionary implications of human brain development by Kuzawa, Christopher W., Chugani, Harry T., Grossman, Lawrence I., Lipovich, Leonard, Muzik, Otto, Hof, Patrick R., Wildman, Derek E., Sherwood, Chet C., Leonard, William R., Lange, Nicholas

“…Significance The metabolic costs of brain development are thought to explain the evolution of humans’ exceptionally slow and protracted childhood growth;…”
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The cellular stress proteins CHCHD10 and MNRR1 (CHCHD2): Partners in mitochondrial and nuclear function and dysfunction by Purandare, Neeraja, Somayajulu, Mallika, Hüttemann, Maik, Grossman, Lawrence I., Aras, Siddhesh

“…Coiled-coil-helix-coiled-coil-helix domain–containing 10 (CHCHD10) and CHCHD2 (MNRR1) are homologous proteins with 58% sequence identity and belong to the twin…”
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Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model by Zheng, Ze, Xu, Xiaohua, Zhang, Xuebao, Wang, Aixia, Zhang, Chunbin, Hüttemann, Maik, Grossman, Lawrence I, Chen, Lung Chi, Rajagopalan, Sanjay, Sun, Qinghua, Zhang, Kezhong

“…Background & Aims Air pollution is a global challenge to public health. Epidemiological studies have linked exposure to ambient particulate matter with…”
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Potential health risk consequences of heavy metal concentrations in surface water, shrimp (Macrobrachium macrobrachion) and fish (Brycinus longipinnis) from Benin River, Nigeria by Ezemonye, Lawrence I., Adebayo, Princewill O., Enuneku, Alex A., Tongo, Isioma, Ogbomida, Emmanuel

“…[Display omitted] •Nickel was the most dominant heavy metal in water while Iron was the most dominant in shrimp and fish.•THQ for heavy metals exposure through…”
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Phosphorus Removal from Waste Waters Using Basic Oxygen Steel Slag by Bowden, Lawrence I, Jarvis, Adam P, Younger, Paul L, Johnson, Karen L

“…Few studies have characterized reactive media for phosphorus (P) removal in passive treatment systems in terms of both batch and continuous flow experiments…”
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The Greatest Gift: How a Patient’s Death Taught Me to Be a Physician by Kaplan, Lawrence I

“…The package was in plain brown paper wrapping. The note enclosed read, "Thanks for everything you did for my father. It meant more than you can ever imagine."…”
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Tissue‐specific regulation of cytochrome c by post‐translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis by Kalpage, Hasini A., Bazylianska, Viktoriia, Recanati, Maurice A., Fite, Alemu, Liu, Jenney, Wan, Junmei, Mantena, Nikhil, Malek, Moh H., Podgorski, Izabela, Heath, Elizabeth I., Vaishnav, Asmita, Edwards, Brian F., Grossman, Lawrence I., Sanderson, Thomas H., Lee, Icksoo, Huttemann, Maik

“…ABSTRACT Cytochrome c (Cytc) plays a vital role in the mitochondrial electron transport chain (ETC). In addition, it is a key regulator of apoptosis. Cytc has…”
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The Insect Neuropeptide PTTH Activates Receptor Tyrosine Kinase Torso to Initiate Metamorphosis by Rewitz, Kim F., Yamanaka, Naoki, Gilbert, Lawrence I., O'Connor, Michael B.

“…Holometabolous insects undergo complete metamorphosis to become sexually mature adults. Metamorphosis is initiated by brain-derived prothoracicotropic hormone…”
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MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism by Aras, Siddhesh, Bai, Minbo, Lee, Icksoo, Springett, Roger, Hüttemann, Maik, Grossman, Lawrence I

“…Our understanding of stress-associated regulatory mechanisms for mitochondria remains incomplete. We now report a new regulator of mitochondrial metabolism,…”
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Progressive supranuclear palsy by Golbe, Lawrence I

“…Progressive supranuclear palsy is a disorder of tau protein aggregation. Its clinical spectrum is now known to be wider than originally described, with a…”
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The transition from physical sibling abuse to bullying perpetration through trait anger: A longitudinal study by Lawrence, Timothy, Wojciechowski, Thomas, Fitzgerald, Michael, Watson, Stephen

“…Objectives Experiencing physical sibling abuse is a form of family violence that is common but understudied. While it is often perceived as a normative aspect…”
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Androgen Receptor Splice Variant, AR-V7, as a Biomarker of Resistance to Androgen Axis-Targeted Therapies in Advanced Prostate Cancer by Zhang, Tian, Karsh, Lawrence I., Nissenblatt, Michael J., Canfield, Steven E.

“…Many therapeutic options are now available for men with metastatic castration-resistant prostate cancer (mCRPC), including next-generation androgen receptor…”
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Rationale and design of ApoA-I Event Reducing in Ischemic Syndromes II (AEGIS-II): A phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to investigate the efficacy and safety of CSL112 in subjects after acute myocardial infarction by Gibson, C. Michael, Kastelein, John J.P., Phillips, Adam T., Aylward, Philip E., Yee, Megan K., Tendera, Michal, Nicholls, Stephen J., Pocock, Stuart, Goodman, Shaun G., Alexander, John H., Lincoff, A. Michael, Bode, Christoph, Duffy, Danielle, Heise, Mark, Berman, Gail, Mears, Sojaita Jenny, Tricoci, Pierluigi, Deckelbaum, Lawrence I., Steg, P. Gabriel, Ridker, Paul, Mehran, Roxana

“…Acute myocardial infarction (MI) patients remain at high risk for recurrent events. Cholesterol efflux, mediated by apolipoprotein A-I, removes excess…”
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Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1) rescues the cellular phenotype of MELAS by inducing homeostatic mechanisms by Aras, Siddhesh, Purandare, Neeraja, Gladyck, Stephanie, Somayajulu-Nitu, Mallika, Zhang, Kezhong, Wallace, Douglas C., Grossman, Lawrence I.

“…MNRR1 (CHCHD2) is a bi-organellar regulator of mitochondrial function that directly activates cytochrome c oxidase in the mitochondria and functions in the…”
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