Search Results - "Lawrence, C W"
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Lipotoxicity-polarised macrophage-derived exosomes regulate mitochondrial fitness through Miro1-mediated mitophagy inhibition and contribute to type 2 diabetes development in mice
Published in Diabetologia (01-12-2023)“…Aims/hypothesis Insulin resistance is a major pathophysiological defect in type 2 diabetes and obesity. Numerous experimental and clinical studies have…”
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Quantifying Benthic δ18O Lags Across Termination 1: A Probabilistic Approach Based on Radiocarbon and Benthic δ18O Chronologies
Published in Geochemistry, geophysics, geosystems : G3 (01-02-2024)“…Temporal offsets (“lags”) between benthic δ18O (δ18Ob) signals in different locations are not only a source of age model uncertainty during δ18Ob stratigraphic…”
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Circulating Plasma MicroRNAs As Diagnostic Markers for NSCLC
Published in Frontiers in genetics (03-11-2016)“…Lung cancer is the most common cause of cancer deaths all over the world, in which non-small cell lung cancer (NSCLC) accounts for ~85% of cases. It is well…”
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MiR-30a-5p Overexpression May Overcome EGFR-Inhibitor Resistance through Regulating PI3K/AKT Signaling Pathway in Non-small Cell Lung Cancer Cell Lines
Published in Frontiers in genetics (15-11-2016)“…Lung cancer is one of the most common deadly diseases worldwide, most of which is non-small cell lung cancer (NSCLC). The epidermal growth factor receptor…”
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KEAP1/NFE2L2 Mutations of Liquid Biopsy as Prognostic Biomarkers in Patients With Advanced Non-Small Cell Lung Cancer: Results From Two Multicenter, Randomized Clinical Trials
Published in Frontiers in oncology (26-07-2021)“…PURPOSEThe KEAP1-NFE2L2 (Kelch-like ECH-associated protein 1 (KEAP1)-Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2)) mutations are associated with…”
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Prognostic Implications of Raphe in Bicuspid Aortic Valve Anatomy
Published in JAMA cardiology (01-03-2017)“…Little is known about the association between bicuspid aortic valve (BAV) morphologic findings and the degree of valvular dysfunction, presence of aortopathy,…”
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Land Surveying and Squatting
Published in Land (Basel) (01-10-2022)“…Although its scale and social implications depend on the specific country or local situations, squatting is a global urban and rural phenomenon associated with…”
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Implications of MicroRNAs in the Treatment of Gefitinib-Resistant Non-Small Cell Lung Cancer
Published in International journal of molecular sciences (01-02-2016)“…Non-small cell lung cancer (NSCLC) represents about 85% of the reported cases of lung cancer. Acquired resistance to targeted therapy with epidermal growth…”
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DECODE: an integrated differential co-expression and differential expression analysis of gene expression data
Published in BMC bioinformatics (31-05-2015)“…Both differential expression (DE) and differential co-expression (DC) analyses are appreciated as useful tools in understanding gene regulation related to…”
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Land Planning, Property Rights and Management of Built Heritage: Some Hong Kong Observations of Colonial Military Buildings
Published in Land (Basel) (01-09-2022)“…There has been much confusion in property rights inquiry into real (immovable) property (i.e., land) between open access and common property, and between…”
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Editorial: Role of RNA in Molecular Diagnostics of Cancer
Published in Frontiers in genetics (06-05-2020)Get full text
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Combination therapy of gefitinib and miR-30a-5p may overcome acquired drug resistance through regulating the PI3K/AKT pathway in non-small cell lung cancer
Published in Therapeutic advances in respiratory disease (2020)“…Background: Non-small cell lung cancer (NSCLC) patients with an epidermal growth factor receptor (EGFR) mutation often initially respond to EGFR tyrosine…”
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ADAM9 Mediates Triple-Negative Breast Cancer Progression via AKT/NF-κB Pathway
Published in Frontiers in medicine (19-06-2020)“…Upregulation of a disintegrin and metalloprotease 9 (ADAM9) is correlated with progression of cancers, such as prostate, bladder, and pancreatic cancers…”
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Farms are not zoos: A post-colonial study on enclosure and conservation of military heritage buildings in Hong Kong
Published in Urban studies (Edinburgh, Scotland) (01-04-2016)“…This paper explains the importance of distinguishing de facto from de jure property rights, confused by some economists, in heritage conservation planning. A…”
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The rise and fall of the sand monopoly in colonial Hong Kong
Published in Ecological economics (01-08-2016)“…A state monopoly over a scarce natural resource under open access can theoretically reduce the costs of supply by constraining rent dissipation and…”
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Editorial: Cancer Diagnostic and Therapeutic Target Identification and Verification Based on the Regulatory Functions of MicroRNAs
Published in Frontiers in genetics (15-11-2017)Get full text
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The Effect of Diabetes Self-Management Education on Body Weight, Glycemic Control, and Other Metabolic Markers in Patients with Type 2 Diabetes Mellitus
Published in Journal of diabetes research (01-01-2014)“…Aims. To comprehensively evaluate the effect of a short-term diabetes self-management education (DSME) on metabolic markers and atherosclerotic parameters in…”
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Exploring microRNA-mediated alteration of EGFR signaling pathway in non-small cell lung cancer using an mRNA:miRNA regression model supported by target prediction databases
Published in Genomics (San Diego, Calif.) (01-12-2014)“…EGFR signaling pathway and microRNAs (miRNAs) are two important factors for development and treatment in non-small cell lung cancer (NSCLC). Microarray…”
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Adipokine Profiling in Adult Women With Central Obesity and Hypertension
Published in Frontiers in physiology (27-03-2018)“…Central obesity and hypertension are common risk factors for the metabolic syndrome, cardiovascular and renal diseases. Studies have shown that it is more…”
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Surveying was a kind of writing on the land: The economics of land division as town planning
Published in Planning theory (London, England) (01-11-2020)“…This article is about the economic role of the primaeval layouts (plats) for a new development area as a conscious act of physical planning. It explains that…”
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