Search Results - "Lawley, T D"

Dietary trehalose enhances virulence of epidemic Clostridium difficile by Collins, J., Robinson, C., Danhof, H., Knetsch, C. W., van Leeuwen, H. C., Lawley, T. D., Auchtung, J. M., Britton, R. A.

“…Clostridium difficile disease has recently increased to become a dominant nosocomial pathogen in North America and Europe, although little is known about what…”
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Zoonotic Transfer of Clostridium difficile Harboring Antimicrobial Resistance between Farm Animals and Humans by Knetsch, C W, Kumar, N, Forster, S C, Connor, T R, Browne, H P, Harmanus, C, Sanders, I M, Harris, S R, Turner, L, Morris, T, Perry, M, Miyajima, F, Roberts, P, Pirmohamed, M, Songer, J G, Weese, J S, Indra, A, Corver, J, Rupnik, M, Wren, B W, Riley, T V, Kuijper, E J, Lawley, T D

“…The emergence of as a significant human diarrheal pathogen is associated with the production of highly transmissible spores and the acquisition of…”
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Current application and future perspectives of molecular typing methods to study Clostridium difficile infections by Knetsch, C W, Lawley, T D, Hensgens, M P, Corver, J, Wilcox, M W, Kuijper, E J

“…Molecular typing is an essential tool to monitor Clostridium difficile infections and outbreaks within healthcare facilities. Molecular typing also plays a key…”
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F factor conjugation is a true type IV secretion system by Lawley, T.D, Klimke, W.A, Gubbins, M.J, Frost, L.S

“…The F sex factor of Escherichia coli is a paradigm for bacterial conjugation and its transfer ( tra) region represents a subset of the type IV secretion system…”
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A pilot study to understand feasibility and acceptability of stool and cord blood sample collection for a large-scale longitudinal birth cohort by Bailey, S R, Townsend, C L, Dent, H, Mallet, C, Tsaliki, E, Riley, E M, Noursadeghi, M, Lawley, T D, Rodger, A J, Brocklehurst, P, Field, N

“…Few data are available to guide biological sample collection around the time of birth for large-scale birth cohorts. We are designing a large UK birth cohort…”
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Gut microbiota and immune profiling of microbiota-humanised versus wildtype mouse models of hepatointestinal schistosomiasis by Stark, K A, Rinaldi, G, Costain, A, Clare, S, Tolley, C, Almeida, A, McCarthy, C, Harcourt, K, Brandt, C, Lawley, T D, Berriman, M, MacDonald, A S, Forde-Thomas, J E, Hulme, B J, Hoffmann, K F, Cantacessi, C, Cortés, A

“…Mounting evidence of the occurrence of direct and indirect interactions between the human blood fluke, Schistosoma mansoni, and the gut microbiota of rodent…”
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Whole genome sequencing reveals potential spread of Clostridium difficile between humans and farm animals in the Netherlands, 2002 to 2011 by Knetsch, C W, Connor, T R, Mutreja, A, van Dorp, S M, Sanders, I M, Browne, H P, Harris, D, Lipman, L, Keessen, E C, Corver, J, Kuijper, E J, Lawley, T D

“…Farm animals are a potential reservoir for human Clostridium difficile infection (CDI), particularly PCR ribotype 078 which is frequently found in animals and…”
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Genomic Epidemiology of a Protracted Hospital Outbreak Caused by a Toxin A-Negative Clostridium difficile Sublineage PCR Ribotype 017 Strain in London, England by Cairns, M D, Preston, M D, Lawley, T D, Clark, T G, Stabler, R A, Wren, B W

“…Clostridium difficile remains the leading cause of nosocomial diarrhea worldwide, which is largely considered to be due to the production of two potent toxins:…”
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Current application and future perspectives of molecular typing methods to study Clostridium difficile infections by Knetsch, C W, Lawley, T D, Hensgens, M P, Corver, J, Wilcox, M W, Kuijper, E J

“…Molecular typing is an essential tool to monitor Clostridium difficile infections and outbreaks within healthcare facilities. Molecular typing also plays a key…”
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The recent emergence of a highly related virulent Clostridium difficile clade with unique characteristics by Shaw, H.A., Preston, M.D., Vendrik, K.E.W., Cairns, M.D., Browne, H.P., Stabler, R.A., Crobach, M.J.T., Corver, J., Pituch, H., Ingebretsen, A., Pirmohamed, M., Faulds-Pain, A., Valiente, E., Lawley, T.D., Fairweather, N.F., Kuijper, E.J., Wren, B.W.

“…Clostridium difficile is a major global human pathogen divided into five clades, of which clade 3 is the least characterized and consists predominantly of PCR…”
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Comparative Genome Analysis and Global Phylogeny of the Toxin Variant Clostridium difficile PCR Ribotype 017 Reveals the Evolution of Two Independent Sublineages by Cairns, M D, Preston, M D, Hall, C L, Gerding, D N, Hawkey, P M, Kato, H, Kim, H, Kuijper, E J, Lawley, T D, Pituch, H, Reid, S, Kullin, B, Riley, T V, Solomon, K, Tsai, P J, Weese, J S, Stabler, R A, Wren, B W

“…The diarrheal pathogen consists of at least six distinct evolutionary lineages. The RT017 lineage is anomalous, as strains only express toxin B, compared to…”
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Identification and validation of two peptide markers for the recognition of Clostridioides difficile MLST-1 and MLST-11 by MALDI-MS by Corver, J., Sen, J., Hornung, B.V.H., Mertens, B.J., Berssenbrugge, E.K.L., Harmanus, C., Sanders, I.M.J.G., Kumar, N., Lawley, T.D., Kuijper, E.J., Hensbergen, P.J., Nicolardi, S.

“…Clostridioides difficile infection (CDI) has become the main cause of nosocomial infective diarrhoea. To survey and control the spread of different…”
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Correction for Cairns et al., "Comparative Genome Analysis and Global Phylogeny of the Toxin Variant Clostridium difficile PCR Ribotype 017 Reveals the Evolution of Two Independent Sublineages" by Cairns, M D, Preston, M D, Hall, C L, Gerding, D N, Hawkey, P M, Kato, H, Kim, H, Kuijper, E J, Lawley, T D, Pituch, H, Reid, S, Kullin, B, Riley, T V, Solomon, K, Tsai, P J, Weese, J S, Stabler, R A, Wren, B W

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The complete DNA sequence and analysis of R27, a large IncHI plasmid from Salmonella typhi that is temperature sensitive for transfer by Sherburne, C K, Lawley, T D, Gilmour, M W, Blattner, F R, Burland, V, Grotbeck, E, Rose, D J, Taylor, D E

“…Salmonella typhi, the causative agent of typhoid fever, annually infects 16 million people and kills 600 000 world wide. Plasmid-encoded multiple drug…”
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Interaction between the IncHI1 plasmid R27 coupling protein and type IV secretion system: TraG associates with the coiled‐coil mating pair formation protein TrhB by Gilmour, Matthew W., Gunton, James E., Lawley, Trevor D., Taylor, Diane E.

“…Summary Assemblies of plasmid‐encoded proteins direct the conjugative transfer of plasmid DNA molecules between bacteria. These include the membrane‐associated…”
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Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies by Kennedy, Katherine M., de Goffau, Marcus C., Perez-Muñoz, Maria Elisa, Arrieta, Marie-Claire, Bäckhed, Fredrik, Bork, Peer, Braun, Thorsten, Bushman, Frederic D., Dore, Joel, de Vos, Willem M., Earl, Ashlee M., Eisen, Jonathan A., Elovitz, Michal A., Ganal-Vonarburg, Stephanie C., Gänzle, Michael G., Garrett, Wendy S., Hall, Lindsay J., Hornef, Mathias W., Huttenhower, Curtis, Konnikova, Liza, Lebeer, Sarah, Macpherson, Andrew J., Massey, Ruth C., McHardy, Alice Carolyn, Koren, Omry, Lawley, Trevor D., Ley, Ruth E., O’Mahony, Liam, O’Toole, Paul W., Pamer, Eric G., Parkhill, Julian, Raes, Jeroen, Rattei, Thomas, Salonen, Anne, Segal, Eran, Segata, Nicola, Shanahan, Fergus, Sloboda, Deborah M., Smith, Gordon C. S., Sokol, Harry, Spector, Tim D., Surette, Michael G., Tannock, Gerald W., Walker, Alan W., Yassour, Moran, Walter, Jens

“…Whether the human fetus and the prenatal intrauterine environment (amniotic fluid and placenta) are stably colonized by microbial communities in a healthy…”
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Functional and Mutational Analysis of Conjugative Transfer Region 1 (Tra1) from the IncHI1 Plasmid R27 by Lawley, Trevor D, Gilmour, Matthew W, Gunton, James E, Standeven, Leah J, Taylor, Diane E

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Functional and Mutational Analysis of Conjugative Transfer Region 2 (Tra2) from the IncHI1 Plasmid R27 by Lawley, Trevor D, Gilmour, Matthew W, Gunton, James E, Tracz, Dobryan M, Taylor, Diane E

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Bacterial conjugative transfer: visualization of successful mating pairs and plasmid establishment in live Escherichia coli by Lawley, Trevor D., Gordon, G. Scott, Wright, Andrew, Taylor, Diane E.

“…Summary We used the LacO/GFP–LacI system to label and visualize the IncPβ plasmid R751 fluorescently during conjugative transfer between live donor and…”
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Cellular location and temperature‐dependent assembly of IncHI1 plasmid R27‐encoded TrhC‐associated conjugative transfer protein complexes by Gilmour, Matthew W., Lawley, Trevor D., Rooker, Michelle M., Newnham, Peter J., Taylor, Diane E.

“…Conjugal transfer of IncHI plasmid DNA between Gram‐negative bacteria is temperature sensitive, as mating is optimal between 22°C and 30°C but is inhibited at…”
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