Search Results - "Lawler, S E"

Methylation-specific multiplex ligation-dependent probe amplification identifies promoter methylation events associated with survival in glioblastoma by Rankeillor, K. L., Cairns, D. A., Loughrey, C., Short, S. C., Chumas, P., Ismail, A., Chakrabarty, A., Lawler, S. E., Roberts, P.

“…DNA methylation plays an important role in cancer biology and methylation events are important prognostic and predictive markers in many tumor types. We have…”
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A Pt(IV)-conjugated brain penetrant macrocyclic peptide shows pre-clinical efficacy in glioblastoma by Jimenez-Macias, J.L., Lee, Y.-C., Miller, E., Finkelberg, T., Zdioruk, M., Berger, G., Farquhar, C.E., Nowicki, M.O., Cho, C.-F., Fedeles, B.I., Loas, A., Pentelute, B.L., Lawler, S.E.

“…Glioblastoma (GBM) is the most aggressive primary malignant brain tumor, with a median survival of approximately 15 months. Treatment is limited by the…”
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MicroRNAs and glioblastoma; the stem cell connection by Godlewski, J, Newton, H B, Chiocca, E A, Lawler, S E

“…Recent data draw close parallels between cancer, including glial brain tumors, and the biology of stem and progenitor cells. At the same time, it has become…”
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Genetic strategies for brain tumor therapy by Lawler, S E, Peruzzi, P P, Chiocca, E A

“…Gene therapy is a potentially useful approach in the treatment of human brain tumors, which are notoriously refractory to conventional approaches. Most human…”
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Profiling cytotoxic microRNAs in pediatric and adult glioblastoma cells by high-content screening, identification, and validation of miR-1300 by Boissinot, M., King, H., Adams, M., Higgins, J., Shaw, G., Ward, T. A., Steele, L. P., Tams, D., Morton, R., Polson, E., da Silva, B., Droop, A., Hayes, J. L., Martin, H., Laslo, P., Morrison, E., Tomlinson, D. C., Wurdak, H., Bond, J., Lawler, S. E., Short, S. C.

“…MicroRNAs play an important role in the regulation of mRNA translation and have therapeutic potential in cancer and other diseases. To profile the landscape of…”
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Cell migration in paediatric glioma; characterisation and potential therapeutic targeting by Cockle, J V, Picton, S, Levesley, J, Ilett, E, Carcaboso, A M, Short, S, Steel, L P, Melcher, A, Lawler, S E, Brüning-Richardson, A

“…Background: Paediatric high grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are highly aggressive brain tumours. Their invasive phenotype…”
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Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320 by Bronisz, A., Godlewski, J., Wallace, J. A., Merchant, A.S., Nowicki, M.O., Mathsyaraja, H., Srinivasan, R., Trimboli, A. J., Martin, C. K., Li, F., Yu, L., Fernandez, S. A., Pécot, T., Rosol, T. J., Cory, S., Hallett, M., Park, M., Piper, M. G., Marsh, C. B., Yee, L. D., Jimenez, R. E., Nuovo, G., Lawler, S. E., Chiocca, E. A., Leone, G., Ostrowski, M. C.

“…PTEN (Phosphatase and tensin homolog deleted on chromosome 10) expression in stromal fibroblasts suppresses epithelial mammary tumours, but the underlying…”
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In vitro screening of clinical drugs identifies sensitizers of oncolytic viral therapy in glioblastoma stem-like cells by Berghauser Pont, L M E, Balvers, R K, Kloezeman, J J, Nowicki, M O, van den Bossche, W, Kremer, A, Wakimoto, H, van den Hoogen, B G, Leenstra, S, Dirven, C M F, Chiocca, E A, Lawler, S E, Lamfers, M L M

“…Oncolytic viruses (OV) have broad potential as an adjuvant for the treatment of solid tumors. The present study addresses the feasibility of clinically…”
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Pattern formation of glioma cells: Effects of adhesion by Khain, E, Schneider-Mizell, C. M, Nowicki, M. O, Chiocca, E. A, Lawler, S. E, Sander, L. M

“…We investigate clustering of malignant glioma cells. In vitro experiments in collagen gels identified a cell line that formed clusters in a region of low cell…”
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OP18 IDENTIFICATION AND CHARACTERISATION OF MICRORNAS INVOLVED IN GLIOBLASTOMA CELL PROLIFERATION AND SURVIVAL by Boissinot, M., Hayes, J., Adams, M., Higgins, J., Tomlinson, D., Lawler, S. E., Short, S.

“…INTRODUCTION: There is a pressing need for new therapeutic approaches for the treatment of glioblastoma (GBM). MicroRNAs(miRs)are single-stranded non-coding…”
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Modifying the substrate specificity of chymosin by Quinn, D, Pitts, J E, Mantafounis, D, Lawler, S E, Uusitalo, J, Penttilä, M, Strop, P

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Protein engineering of the surface loops of chymosin by Orprayoon, P, Pitts, J E, Nugent, P, Mantafounis, D, Lawler, S E, Blundell, T L, Uusitalo, J, Penttilä, M

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HLA class II-induced translocation of PKC alpha and PKC beta II isoforms is abrogated following truncation of DR beta cytoplasmic domains by Rich, T, Lawler, SE, Lord, JM, Blancheteau, VM, Charron, DJ, Mooney, NA

“…Several studies have attempted to identify regions of the MHC class II molecule that participate in signal transduction. The importance of intact murine I-A…”
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Highlights from the Literature by Bhat, K. P., Lawler, S. E., Pope, W. B., Schiff, D., Aldape, K.

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P01.01 Ectopic expression of microRNA-1300 in adult and paediatric glioma cells induces cytokinesis failure and apoptosis via ECT2 by Boissinot, M., King, H., Adams, M., Higgins, J., Steele, L. P., Wurdak, H., Bond, J., Tomlinson, D. C., Lawler, S. E., Short, S. C.

“…MicroRNAs are proving to be potent tumour suppressors in cancer. Many microRNAs are in pre-clinical and clinical validation. A high-throughput screen was…”
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AI-27 BKM-120: AN ANTI-INVASIVE CANDIDATE FOR THE TREATMENT OF GLIOBLASTOMA by Speranza, M. C., Nowicki, M. O., Antonio Chiocca, E., Lawler, S. E.

“…BKM-120 is a selective pan-class I phosphatidyl-inositol-3 kinase (PI3K) inhibitor. BKM-120 can penetrate the blood-brain barrier and it is currently in…”
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CB-03 IDENTIFICATION AND CHARACTERISATION OF MicroRNAs INVOLVED IN GLIOBLASTOMA CELL PROLIFERATION AND SURVIVAL USING HIGH-THROUGHPUT SCREENING by Boissinot, M., Hayes, J., Adams, M., Higgins, J., Tomlinson, D., Lawler, S. E., Short, S. C.

“…INTRODUCTION MicroRNAs, single-stranded non-coding RNAs that function by reducing translation or causing degradation of target mRNAs, have been shown to play…”
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Pattern Formation of Glioma Cells: Effects of Adhesion by Khain, Evgeniy, Schneider-Mizell, Casey M, Nowicki, Michal O, Chiocca, E. Antonio, Lawler, S. E, Sander, Leonard M

“…EPL (Europhysics Letters) 88, 28006 (2009) We investigate clustering of malignant glioma cells. \emph{In vitro} experiments in collagen gels identified a cell…”
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Secretion of a chymosin-insulin fusion in Trichoderma reesei by Lawler, S E, Pitts, J E, Mantafounis, D, Gill, R, Uusitalo, J, Penttilä, M

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Glioma cell migration on 3D nanofiber scaffolds is regulated by substrate topography and abolished by inhibition of STAT3 signaling by Agudelo, P, de Jesus, JK, Williams, S P, Nowicki, MO, Chiocca, E A, Liyanarachchi, S, Li, P-K, Lannutti, J J, Johnson, J K, Lawler, SE, Viapiano, MS

“…A hallmark of malignant gliomas is their ability to disperse through neural tissue, leading to long-term failure of all known therapies. Identifying new…”
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