Search Results - "Lawe, Deirdre"

Sorting of EGF and transferrin at the plasma membrane and by cargo-specific signaling to EEA1-enriched endosomes by Leonard, Deborah, Hayakawa, Akira, Lawe, Deirdre, Lambright, David, Bellve, Karl D, Standley, Clive, Lifshitz, Lawrence M, Fogarty, Kevin E, Corvera, Silvia

“…The biological function of receptors is determined by their appropriate trafficking through the endosomal pathway. Following internalization, the transferrin…”
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Structural Basis for Endosomal Targeting by FYVE Domains by Hayakawa, Akira, Hayes, Susan J., Lawe, Deirdre C., Sudharshan, Eathiraj, Tuft, Richard, Fogarty, Kevin, Lambright, David, Corvera, Silvia

“…The FYVE domain is a conserved protein motif characterized by its ability to bind with high affinity and specificity to phosphatidylinositol 3-phosphate…”
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A functional PtdIns(3)P-binding motif by Patki, Varsha, Lawe, Deirdre C, Corvera, Silvia, Virbasius, Joseph V, Chawla, Anil

“…Treating cells with the phosphatidylinositol-3-OH kinase (PI(3)K) inhibitor wortmannin causes the dissociation of the early-endosomal antigen EEA1 from early…”
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Sequential Roles for Phosphatidylinositol 3-Phosphate and Rab5 in Tethering and Fusion of Early Endosomes via Their Interaction with EEA1 by Lawe, Deirdre C, Chawla, Anil, Merithew, Eric, Dumas, John, Carrington, Walter, Fogarty, Kevin, Lifshitz, Lawrence, Tuft, Richard, Lambright, David, Corvera, Silvia

“…Early endosome antigen 1 (EEA1) is a 170-kDa polypeptide required for endosome fusion in mammalian cells. The COOH terminus of EEA1 contains a FYVE domain that…”
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Structural Plasticity of an Invariant Hydrophobic Triad in the Switch Regions of Rab GTPases Is a Determinant of Effector Recognition by Merithew, E, Hatherly, S, Dumas, J J, Lawe, D C, Heller-Harrison, R, Lambright, D G

“…Rab GTPases function as regulatory components of an evolutionarily conserved machinery that mediates docking, priming, and fusion of vesicles with…”
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The Nck SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68 by LAWE, D. C, HAHN, C, WONG, A. J

“…SH2/SH3 adaptor proteins are essential components of the signal transduction pathways initiated by tyrosine kinases. Nck is a ubiquitously expressed adaptor…”
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Essential role of Ca2+/calmodulin in Early Endosome Antigen-1 localization by Lawe, Deirdre C, Sitouah, Nachida, Hayes, Susan, Chawla, Anil, Virbasius, Joseph V, Tuft, Richard, Fogarty, Kevin, Lifshitz, Lawrence, Lambright, David, Corvera, Silvia

“…Ca2+ is an essential requirement in membrane fusion, acting through binding proteins such as calmodulin (CaM). Ca2+/CaM is required for early endosome fusion…”
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Multivalent Endosome Targeting by Homodimeric EEA1 by Dumas, John J., Merithew, Eric, Sudharshan, E., Rajamani, Deepa, Hayes, Susan, Lawe, Deirdre, Corvera, Silvia, Lambright, David G.

“…Early endosome autoantigen localization to early endosomes is mediated by a C-terminal region, which includes a calmodulin binding motif, a Rab5 interaction…”
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The FYVE Domain of Early Endosome Antigen 1 Is Required for Both Phosphatidylinositol 3-Phosphate and Rab5 Binding by Lawe, Deirdre C., Patki, Varsha, Heller-Harrison, Robin, Lambright, David, Corvera, Silvia

“…Early endosome antigen 1 (EEA1) is 170-kDa polypeptide required for endosome fusion. EEA1 binds to both phosphtidylinositol 3-phosphate (PtdIns3P) and to…”
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The FYVE domain of early endosome antigen 1 is required for both phosphatidylinositol 3-phosphate and Rab5 binding. Critical role of this dual interaction for endosomal localization by Lawe, D C, Patki, V, Heller-Harrison, R, Lambright, D, Corvera, S

“…Early endosome antigen 1 (EEA1) is 170-kDa polypeptide required for endosome fusion. EEA1 binds to both phosphtidylinositol 3-phosphate (PtdIns3P) and to…”
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Association of Myn, the murine homolog of max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation by Prendergast, G C, Lawe, D, Ziff, E B

“…Myn, a novel murine approximately 18 kd basic/helix-loop-helix/"leucine zipper" (B/HLH/LZ) protein, forms a specific DNA-binding complex with the c-Myc…”
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Essential role of Ca 2+ /Calmodulin in Early Endosome Antigen-1 Localization by Lawe, Deirdre C., Sitouah, Nachida, Hayes, Susan, Chawla, Anil, Virbasius, Joseph V., Tuft, Richard, Fogarty, Kevin, Lifshitz, Lawrence, Lambright, David, Corvera, Silvia

“…Ca 2+ is an essential requirement in membrane fusion, acting through binding proteins such as calmodulin (CaM). Ca 2+ /CaM is required for early endosome…”
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Essential role of Ca2+/Calmodulin in Early Endosome Antigen-1 Localization V by Lawe, Deirdre C., Sitouah, Nachida, Hayes, Susan, Chawla, Anil, Virbasius, Joseph V., Tuft, Richard, Fogarty, Kevin, Lifshitz, Lawrence, Lambright, David, Corvera, Silvia

“…Ca 2+ is an essential requirement in membrane fusion, acting through binding proteins such as calmodulin (CaM). Ca 2+ /CaM is required for early endosome…”
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Sequential Roles for Phosphatidylinositol 3-Phosphate and Rab5 in Tethering and Fusion of Early Endosomes via Their Interaction with EEA1210 by Lawe, Deirdre C., Chawla, Anil, Merithew, Eric, Dumas, John, Carrington, Walter, Fogarty, Kevin, Lifshitz, Lawrence, Tuft, Richard, Lambright, David, Corvera, Silvia

“…Early endosome antigen 1 (EEA1) is a 170-kDa polypeptide required for endosome fusion in mammalian cells. The COOH terminus of EEA1 contains a FYVE domain that…”
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Correlation between E2F-1 requirement in the S phase and E2F-1 transactivation of cell cycle-related genes in human cells by SALA, A, NICOLAIDES, N. C, ENGELHARD, A, BELLON, T, LAWE, D. C, FARNOLD, A, GRANA, X, GIORDANO, A, CALABRETTA, B

“…The mammalian nuclear protein E2F-1 has recently been cloned based on its ability to bind the retinoblastoma protein. To determine whether E2F-1 plays a role…”
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The molecular and cellular characterization of Nck, an SH2/SH3 adaptor protein, in signal transduction by Lawe, Deirdre C

“…SH2/SH3 adaptor proteins are essential components of the signal transduction pathways initiated by cytoplasmic tyrosine kinases. Nck is a ubiquitously…”
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Nerve growth factor-induced derepression of peripherin gene expression is associated with alterations in proteins binding to a negative regulatory element by THOMPSON, M. A, LEE, E, LAWE, D, GIZANG-GINSBERG, E, ZIFF, E. B

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Nerve Growth Factor-Induced Derepression of Peripherin Gene Expression Is Associated with Alterations in Proteins Binding to a Negative Regulatory Element by Thompson, Mary Ann, Lee, Eunmee, Lawe, Deirdre, Gizang-Ginsberg, Elena, Ziff, Edward B.

“…The peripherin gene, which encodes a neuronal-specific intermediate filament protein, is transcriptionally induced with a late time course when nerve growth…”
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