Search Results - "Law, V. S"
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Conversion of thrombin into an anticoagulant by protein engineering
Published in Nature (London) (23-11-1995)“…At sites of vascular injury, thrombin interacts with multiple procoagulant substrates, to mediate both fibrin clotting and platelet aggregation. But upon…”
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In Vitro and in Vivo Activities of Oligodeoxynucleotide-Based Thrombin Inhibitors Containing Neutral Formacetal Linkages
Published in Journal of medicinal chemistry (22-10-1998)“…A series of 15-mer oligodeoxynucleotide analogues were synthesized, and their thrombin inhibitory activities in vitro and in vivo were evaluated. These…”
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Pilot study of the efficacy of a thrombin inhibitor for use during cardiopulmonary bypass
Published in The Annals of thoracic surgery (01-08-1994)“…Heparin is normally used for anticoagulation during cardiopulmonary bypass (CPB), but its use is contraindicated in patients with a history of heparin-induced…”
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N2- and C8-Substituted Oligodeoxynucleotides with Enhanced Thrombin Inhibitory Activity in Vitro and in Vivo
Published in Journal of medicinal chemistry (18-06-1998)“…2‘-Deoxyguanosine (G) analogues carrying various hydrophobic substituents in the N2 and C8 positions were synthesized and introduced through solid-phase…”
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A peptide derived from a tissue factor loop region functions as a tissue factor-factor VIIa antagonist
Published in Biochemistry (Easton) (21-11-1995)“…Tissue factor (TF) is a transmembrane protein that functions in the initiation of blood coagulation in vivo. At sites of vascular injury, TF serves as a…”
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N super(2) and C super(8)-Substituted Oligodeoxynucleotides with Enhanced Thrombin Inhibitory Activity in Vitro and in Vivo
Published in Journal of medicinal chemistry (01-06-1998)“…2'-Deoxyguanosine (G) analogues carrying various hydrophobic substituents in the N super(2) and C super(8) positions were synthesized and introduced through…”
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N 2 - and C 8 -Substituted Oligodeoxynucleotides with Enhanced Thrombin Inhibitory Activity in Vitro and in Vivo
Published in Journal of medicinal chemistry (18-06-1998)Get full text
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Pilot study of the efficacy of a thrombin inhibitor for use during cardipulmonary bypass. Discussion
Published in The Annals of thoracic surgery (1994)Get full text
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