Search Results - "Law, Susan F"

Bone Aging, Cellular Senescence, and Osteoporosis by Pignolo, Robert J, Law, Susan F, Chandra, Abhishek

“…ABSTRACT Changes in aging bone that lead to osteoporosis are mediated at multiple levels, including hormonal alterations, skeletal unloading, and accumulation…”
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An unbiased proteomics approach to identify the senescence-associated secretory phenotype of human bone marrow-derived mesenchymal stem cells by Samsonraj, Rebekah M., Law, Susan F., Chandra, Abhishek, Pignolo, Robert J.

“…Mesenchymal stem cells (MSCs) derived from bone marrow can support skeletal tissue repair and regeneration owing to their self-renewing capacity,…”
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Targeting Cell Senescence for the Treatment of Age-Related Bone Loss by Pignolo, Robert J., Samsonraj, Rebekah M., Law, Susan F., Wang, Haitao, Chandra, Abhishek

“…Purpose of Review We review cell senescence in the context of age-related bone loss by broadly discussing aging mechanisms in bone, currently known inducers…”
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Focal adhesion kinase regulates β1 integrin‐dependent T cell migration through an HEF1 effector pathway by Seventer, Gijs A. van, Salmen, Heinz J., Law, Susan F., O'Neill, Geraldine M., Mullen, Maureen M., Franz, Aric M., Kanner, Steven B., Golemis, Erica A., Seventer, Jean Maguire van

“…Although β1 integrin‐dependent T cell migration is required for immune function, little is known of the signaling pathways regulating this migration. We now…”
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Vectors to target protein domains to different cellular compartments by Toby, G, Law, S F, Golemis, E A

“…The pcDNA3 mammalian expression vector uses the cytomegalovirus (CMV) promoter to express proteins cloned into an adjacent polylinker. We have modified this…”
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The Docking Protein HEF1 Is an Apoptotic Mediator at Focal Adhesion Sites by Law, Susan F., O'Neill, Geraldine M., Fashena, Sarah J., Einarson, Margret B., Golemis, Erica A.

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A novel ability of Smad3 to regulate proteasomal degradation of a Cas family member HEF1 by Liu, Xiaohong, Elia, Andrew E. H., Law, Susan F., Golemis, Erica A., Farley, Jennifer, Wang, Tongwen

“…Smad3 is a key signal transducer of transforming growth factor‐β (TGF‐β) and activin, and is known to be a DNA‐binding transcriptional regulator. Here we…”
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Cell Cycle-Regulated Processing of HEF1 to Multiple Protein Forms Differentially Targeted to Multiple Subcellular Compartments by Law, Susan F., Zhang, Yu-Zhu, Klein-Szanto, Andres J. P., Golemis, Erica A.

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Differential Signaling after β1 Integrin Ligation Is Mediated Through Binding of CRKL to p120 and p110 by Sattler, Martin, Salgia, Ravi, Shrikhande, Gautam, Verma, Shalini, Uemura, Naoki, Law, Susan F., Golemis, Erica A., Griffin, James D.

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Changes in the association of G protein subunits with the cloned mouse delta opioid receptor on agonist stimulation by Law, S F, Reisine, T

“…G proteins couple delta opioid receptors to multiple cellular effector systems and are critical components of the delta opioid signal transduction cascade. To…”
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Molecular mechanisms of opiate receptor coupling to G proteins and effector systems by Reisine, T, Law, S F, Blake, A, Tallent, M

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Involvement of p130Cas and p105HEF1, a Novel Cas-like Docking Protein, in a Cytoskeleton-dependent Signaling Pathway Initiated by Ligation of Integrin or Antigen Receptor on Human B Cells by Manié, Serge N., Beck, Andreas R.P., Astier, Anne, Law, Susan F., Canty, Tim, Hirai, Hisamaru, Druker, Brian J., Avraham, Hava, Haghayeghi, Nilou, Sattler, Martin, Salgia, Ravi, Griffin, James D., Golemis, Erica A., Freedman, Arnold S.

“…The Crk-associated substrate p130Cas (Cas) and the recently described human enhancer of filamentation 1 (HEF1) are two proteins with similar structure (64%…”
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The Related Adhesion Focal Tyrosine Kinase Differentially Phosphorylates p130Cas and the Cas-like Protein, p105HEF1 by Astier, Anne, Manié, Serge N., Avraham, Hava, Hirai, Hisamaru, Law, Susan F., Zhang, Yuzhu, Golemis, Erica A., Fu, Yigong, Druker, Brian J., Haghayeghi, Nilou, Freedman, Arnold S., Avraham, Shalom

“…The related adhesion focal tyrosine kinase (RAFTK) is tyrosine-phosphorylated following β1 integrin or B cell antigen receptor stimulation in human B cells…”
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Giα3 and Goα selectively associate with the cloned somatostatin receptor subtype SSTR2 by LAW, S. F, YASUDA, K, BELL, G. I, REISINE, T

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Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase by Yamada, Y, Reisine, T, Law, S F, Ihara, Y, Kubota, A, Kagimoto, S, Seino, M, Seino, Y, Bell, G I, Seino, S

“…We previously reported the cloning of two distinct somatostatin receptor (SSTR) subtypes, SSTR1 and SSTR2. Although both SSTR1 and SSTR2 bound somatostatin…”
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Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase by YASUDA, K, RENS-DOMIANO, S, BREDER, C. D, LAW, S. F, SAPER, C. B, REISINE, T, BELL, G. I

“…The gene encoding a novel mouse somatostatin receptor termed mSSTR3 was isolated and characterized. The sequence of mSSTR3 shows 46 and 47% identity with…”
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Dimerization of the Docking/Adaptor Protein HEF1 via a Carboxy-Terminal Helix-Loop-Helix Domain by Law, Susan F., Zhang, Yu-Zhu, Fashena, Sarah J., Toby, Garabet, Estojak, Joanne, Golemis, Erica A.

“…HEF1, p130Cas, and Efs define a family of multidomain docking proteins which plays a central coordinating role for tyrosine-kinase-based signaling related to…”
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Identification of the subunits of GTP-binding proteins coupled to somatostatin receptors by Law, S.F, Manning, D, Reisine, T

“…Somatostatin (SRIF) induces its biological effects by interacting with membrane-bound receptors that are linked to cellular effector systems via G proteins. We…”
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Pharmacological properties of two cloned somatostatin receptors by Rens-Domiano, S, Law, S F, Yamada, Y, Seino, S, Bell, G I, Reisine, T

“…Previous studies have shown that at least two subtypes of somatostatin (SRIF) receptors (SRIF1 and SRIF2) are expressed in mammalian cells. SRIF1 receptors…”
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Somatostatin receptor activation of cellular effector systems by Law, Susan F., Woulfe, Donna, Reisine, Terry

“…Somatostatin (SRIF) induces its multiple biological actions by interacting with a family of receptors, referred to as SSTR1-SSTR5. These receptors are capable…”
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