Search Results - "Law, Robert"

Vesicle-based artificial cells as chemical microreactors with spatially segregated reaction pathways by Elani, Yuval, Law, Robert V., Ces, Oscar

“…In the discipline of bottom-up synthetic biology, vesicles define the boundaries of artificial cells and are increasingly being used as biochemical…”
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Protein synthesis in artificial cells: using compartmentalisation for spatial organisation in vesicle bioreactors by Elani, Yuval, Law, Robert V, Ces, Oscar

“…Whereas spatial organisation of function is ubiquitous in biology, it has been lacking in artificial cells. We rectify this by using multi-compartment vesicles…”
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Engineering Compartmentalized Biomimetic Micro- and Nanocontainers by Trantidou, Tatiana, Friddin, Mark, Elani, Yuval, Brooks, Nicholas J, Law, Robert V, Seddon, John M, Ces, Oscar

“…Compartmentalization of biological content and function is a key architectural feature in biology, where membrane bound micro- and nanocompartments are used…”
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Constructing vesicle-based artificial cells with embedded living cells as organelle-like modules by Elani, Yuval, Trantidou, Tatiana, Wylie, Douglas, Dekker, Linda, Polizzi, Karen, Law, Robert V., Ces, Oscar

“…There is increasing interest in constructing artificial cells by functionalising lipid vesicles with biological and synthetic machinery. Due to their reduced…”
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Light-triggered enzymatic reactions in nested vesicle reactors by Hindley, James W., Elani, Yuval, McGilvery, Catriona M., Ali, Simak, Bevan, Charlotte L., Law, Robert V., Ces, Oscar

“…Cell-sized vesicles have tremendous potential both as miniaturised pL reaction vessels and in bottom-up synthetic biology as chassis for artificial cells. In…”
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Biomimetic behaviors in hydrogel artificial cells through embedded organelles by Allen, Matthew E., Hindley, James W., O’Toole, Nina, Cooke, Hannah S., Contini, Claudia, Law, Robert V., Ces, Oscar, Elani, Yuval

“…Artificial cells are biomimetic structures formed from molecular building blocks that replicate biological processes, behaviors, and architectures. Of these…”
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Building a synthetic mechanosensitive signaling pathway in compartmentalized artificial cells by Hindley, James W., Zheleva, Daniela G., Elani, Yuval, Charalambous, Kalypso, Barter, Laura M. C., Booth, Paula J., Bevan, Charlotte L., Law, Robert V., Ces, Oscar

“…To date, reconstitution of one of the fundamental methods of cell communication, the signaling pathway, has been unaddressed in the bottom-up construction of…”
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The rate of transient beta frequency events predicts behavior across tasks and species by Shin, Hyeyoung, Law, Robert, Tsutsui, Shawn, Moore, Christopher I, Jones, Stephanie R

“…Beta oscillations (15-29Hz) are among the most prominent signatures of brain activity. Beta power is predictive of healthy and abnormal behaviors, including…”
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Chan–Evans–Lam Amination of Boronic Acid Pinacol (BPin) Esters: Overcoming the Aryl Amine Problem by Vantourout, Julien C, Law, Robert P, Isidro-Llobet, Albert, Atkinson, Stephen J, Watson, Allan J. B

“…The Chan–Evans–Lam reaction is a valuable C–N bond forming process. However, aryl boronic acid pinacol (BPin) ester reagents can be difficult coupling partners…”
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Thalamocortical Mechanisms Regulating the Relationship between Transient Beta Events and Human Tactile Perception by Law, Robert G, Pugliese, Sarah, Shin, Hyeyoung, Sliva, Danielle D, Lee, Shane, Neymotin, Samuel, Moore, Christopher, Jones, Stephanie R

“…Abstract Transient neocortical events with high spectral power in the 15–29 Hz beta band are among the most reliable predictors of sensory perception…”
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Activating mechanosensitive channels embedded in droplet interface bilayers using membrane asymmetry by Strutt, Robert, Hindley, James W, Gregg, Jordan, Booth, Paula J, Harling, John D, Law, Robert V, Friddin, Mark S, Ces, Oscar

“…Droplet microcompartments linked by lipid bilayers show great promise in the construction of synthetic minimal tissues. Central to controlling the flow of…”
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A Direct Podocalyxin-Dynamin-2 Interaction Regulates Cytoskeletal Dynamics to Promote Migration and Metastasis in Pancreatic Cancer Cells by Wong, Bin Sheng, Shea, Daniel J, Mistriotis, Panagiotis, Tuntithavornwat, Soontorn, Law, Robert A, Bieber, Jake M, Zheng, Lei, Konstantopoulos, Konstantinos

“…The sialoglycoprotein podocalyxin is absent in normal pancreas but is overexpressed in pancreatic cancer and is associated with poor clinical outcome. Here, we…”
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Fluoride-containing bioactive glasses: Effect of glass design and structure on degradation, pH and apatite formation in simulated body fluid by Brauer, Delia S., Karpukhina, Natalia, O’Donnell, Matthew D., Law, Robert V., Hill, Robert G.

“…Bioactive glasses are able to bond to bone through formation of carbonated hydroxyapatite in body fluids, and fluoride-releasing bioactive glasses are of…”
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Confinement hinders motility by inducing RhoA-mediated nuclear influx, volume expansion, and blebbing by Mistriotis, Panagiotis, Wisniewski, Emily O, Bera, Kaustav, Keys, Jeremy, Li, Yizeng, Tuntithavornwat, Soontorn, Law, Robert A, Perez-Gonzalez, Nicolas A, Erdogmus, Eda, Zhang, Yuqi, Zhao, Runchen, Sun, Sean X, Kalab, Petr, Lammerding, Jan, Konstantopoulos, Konstantinos

“…Cells migrate in vivo through complex confining microenvironments, which induce significant nuclear deformation that may lead to nuclear blebbing and nuclear…”
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Measurements of the effect of membrane asymmetry on the mechanical properties of lipid bilayers by Elani, Yuval, Purushothaman, Sowmya, Booth, Paula J, Seddon, John M, Brooks, Nicholas J, Law, Robert V, Ces, Oscar

“…We detail an approach for constructing asymmetric membranes and characterising their mechanical properties, leading to the first measurement of the effect of…”
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Discovery of Tetrahydroquinoxalines as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the Second Bromodomain by Law, Robert P, Atkinson, Stephen J, Bamborough, Paul, Chung, Chun-wa, Demont, Emmanuel H, Gordon, Laurie J, Lindon, Matthew, Prinjha, Rab K, Watson, Allan J. B, Hirst, David J

“…The bromodomain and extra-terminal domain (BET) family of proteins bind acetylated lysine residues on histone proteins. The four BET bromodomainsBRD2, BRD3,…”
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Discovery and Characterisation of Highly Cooperative FAK‐Degrading PROTACs by Law, Robert P., Nunes, Joao, Chung, Chun‐wa, Bantscheff, Marcus, Buda, Karol, Dai, Han, Evans, John P., Flinders, Adam, Klimaszewska, Diana, Lewis, Antonia J., Muelbaier, Marcel, Scott‐Stevens, Paul, Stacey, Peter, Tame, Christopher J., Watt, Gillian F., Zinn, Nico, Queisser, Markus A., Harling, John D., Benowitz, Andrew B.

“…Focal adhesion kinase (FAK) is a key mediator of tumour progression and metastasis. To date, clinical trials of FAK inhibitors have reported disappointing…”
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Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes by Lyons, James S, Joca, Humberto C, Law, Robert A, Williams, Katrina M, Kerr, Jaclyn P, Shi, Guoli, Khairallah, Ramzi J, Martin, Stuart S, Konstantopoulos, Konstantinos, Ward, Christopher W, Stains, Joseph P

“…The adaptation of the skeleton to its mechanical environment is orchestrated by mechanosensitive osteocytes, largely by regulating the abundance of sclerostin,…”
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UV-DIB: label-free permeability determination using droplet interface bilayers by Strutt, Robert, Sheffield, Felix, Barlow, Nathan E, Flemming, Anthony J, Harling, John D, Law, Robert V, Brooks, Nicholas J, Barter, Laura M C, Ces, Oscar

“…Simple diffusion of molecular entities through a phospholipid bilayer, is a phenomenon of great importance to the pharmaceutical and agricultural industries…”
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Drug interactions with lipid membranes by Seddon, Annela M, Casey, Duncan, Law, Robert V, Gee, Antony, Templer, Richard H, Ces, Oscar

“…The field of drug-membrane interactions is one that spans a wide range of scientific disciplines, from synthetic chemistry, through biophysics to pharmacology…”
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