Search Results - "Law, Lee"
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Erlotinib-loaded carboxymethyl temarind gum semi-interpenetrating nanocomposites
Published in Carbohydrate polymers (15-02-2020)“…[Display omitted] •CMTG-g-PNIPA-MMT based semi-IPN NCs was synthesized.•It depicted excellent biodegradability and pH/temperature-dependent swelling.•ERL was…”
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MicroRNAs and extracellular vesicles in cholangiopathies
Published in Biochimica et biophysica acta. Molecular basis of disease (01-04-2018)“…Cholangiopathies encompass a heterogeneous group of disorders affecting biliary epithelial cells (i.e. cholangiocytes). Early diagnosis, prognosis and…”
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Synthetic Conjugates of Ursodeoxycholic Acid Inhibit Cystogenesis in Experimental Models of Polycystic Liver Disease
Published in Hepatology (Baltimore, Md.) (01-01-2021)“…Background and Aims Polycystic liver diseases (PLDs) are genetic disorders characterized by progressive development of symptomatic biliary cysts. Current…”
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4
Multiple Wnts are involved in Hydra organizer formation and regeneration
Published in Developmental biology (01-06-2009)“…Wnt genes and β-Catenin signaling are involved in axial patterning processes in vertebrate embryogenesis in setting up the Spemann–Mangold organizer in…”
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Targeting UBC9-mediated protein hyper-SUMOylation in cystic cholangiocytes halts polycystic liver disease in experimental models
Published in Journal of hepatology (01-02-2021)“…Polycystic liver diseases (PLDs) are genetic disorders characterized by progressive development of multiple fluid-filled biliary cysts. Most PLD-causative…”
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New Advances in Polycystic Liver Diseases
Published in Seminars in liver disease (01-02-2017)“…Polycystic liver diseases (PLDs) include a heterogeneous group of congenital disorders inherited as dominant or recessive genetic traits; they are manifested…”
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Inhibition of NAE‐dependent protein hyper‐NEDDylation in cystic cholangiocytes halts cystogenesis in experimental models of polycystic liver disease
Published in United European gastroenterology journal (01-09-2021)“…Background Polycystic liver diseases (PLDs) are genetic inherited disorders characterized by the progressive growth of numerous intrahepatic biliary cysts,…”
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Genetics of polycystic liver diseases
Published in Current opinion in gastroenterology (01-03-2019)“…PURPOSE OF REVIEWThis review provides an outline of the most recent insights and significant discoveries regarding the genetic mechanisms involved in…”
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Barriers And Challenges Of Multidisciplinary Teams In Oncology Management: A Scoping Review Protocol
Published in BMJ open (10-02-2024)“…IntroductionMultidisciplinary teams (MDTs) are integral to oncology management, involving specialised healthcare professionals who collaborate to develop…”
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Targeting NAE1-mediated protein hyper-NEDDylation halts cholangiocarcinogenesis and impacts on tumor-stroma crosstalk in experimental models
Published in Journal of hepatology (01-07-2022)“…Cholangiocarcinoma (CCA) comprises a heterogeneous group of malignant tumors associated with dismal prognosis. Alterations in post-translational modifications…”
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11
Improving alginate-poly-L-ornithine-alginate capsule biocompatibility through genipin crosslinking
Published in Journal of biomedical materials research. Part B, Applied biomaterials (01-02-2013)“…DIABECELL® capsules comprise an inner core of alginate (Alg) coated with a polycationic polymer, poly‐L‐ornithine (PLO), designed as a stabilizing agent for…”
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12
Core-shell structured pullulan based nanocomposites as erlotinib delivery shuttles
Published in International journal of polymeric materials (01-09-2020)“…Anionic biopolymer (sodium alginate/low-methoxyl pectin/gellan gum) coated carboxymethyl pullulan-ZnO nanocomposites encapsulating erlotinib were developed for…”
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13
Targeting Connexin43 Expression Accelerates the Rate of Wound Repair
Published in Current biology (30-09-2003)“…The repair of tissue damage is a key survival process in all organisms and involves the coordinated activation of several cell types. Cell-cell communication…”
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The anti-inflammatory receptor TREM-2 protects the liver from hepatocellular carcinoma development
Published in Journal of hepatology (2017)Get full text
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15
Uncoupling Molecular Testing for SARS-CoV-2 From International Supply Chains
Published in Frontiers in public health (24-01-2022)“…The rapid global rise of COVID-19 from late 2019 caught major manufacturers of RT-qPCR reagents by surprise and threw into sharp focus the heavy reliance of…”
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16
The dynamic genome of Hydra
Published in Nature (London) (25-03-2010)“…The freshwater cnidarian Hydra was first described in 1702 and has been the object of study for 300 years. Experimental studies of Hydra between 1736 and 1744…”
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Chemosensitivity assessments of curdlan-doped smart nanocomposites containing erlotinib HCl
Published in International journal of biological macromolecules (30-06-2021)“…Curdlan (CN)-doped montmorillonite/poly(N-isopropylacrylamide-co-N,N′-methylene-bis-acrylamide) [CN/MT/P(NIPA-co-MBA)] smart nanocomposites (NCs) were…”
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SAT-223 - Therapeutic potential of targeting protein hyper-SUMOylation in cholangiocarcinoma
Published in Journal of hepatology (01-06-2023)Get full text
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Therapeutic potential of targeting protein hyper-SUMOylation in cholangiocarcinoma
Published in Journal of hepatology (01-06-2023)Get full text
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20
Targeting NAE1-mediated protein hyper-NEDDylation halts cholangiocarcinogenesis and impacts on tumor-stroma crosstalk in experimental models
Published in Journal of hepatology (01-07-2022)“…Cholangiocarcinoma (CCA) comprises a heterogeneous group of malignant tumors associated with dismal prognosis. Alterations in post-translational modifications…”
Get full text
Journal Article